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Effect of Yiqi Huoxue herbs on vascular endothelial cells and platelets in patients with chronic cor pulmonale
- Chinese Journal of Integrative Medicine Vol. 10, Issue 1, Pages: 19-24(2004)
- Affiliations：
The Second Hospital of Shandong University,Jinan
- Author bio：
- Funds：
DOI：10.1007/BF02836552
CLC：Published：2004，
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Wei, W., Shao-hua, X., Ying, Z. et al. Effect of Yiqi Huoxue herbs on vascular endothelial cells and platelets in patients with chronic cor pulmonale., Chin. J. Integr. Med. 10, 19–24 (2004). https://doi.org/10.1007/BF02836552
Wang Wei, Xu Shao-hua, Zhang Ying, et al. Effect of Yiqi Huoxue herbs on vascular endothelial cells and platelets in patients with chronic cor pulmonale. [J]. Chinese Journal of Integrative Medicine 10(1):19-24(2004)
Wei, W., Shao-hua, X., Ying, Z. et al. Effect of Yiqi Huoxue herbs on vascular endothelial cells and platelets in patients with chronic cor pulmonale., Chin. J. Integr. Med. 10, 19–24 (2004). https://doi.org/10.1007/BF02836552 DOI：
Wang Wei, Xu Shao-hua, Zhang Ying, et al. Effect of Yiqi Huoxue herbs on vascular endothelial cells and platelets in patients with chronic cor pulmonale. [J]. Chinese Journal of Integrative Medicine 10(1):19-24(2004) DOI： 10.1007/BF02836552.
摘要
Objective: To observe the clinical effect of Yiqi Huoxue
YQHX) herbs in treating the patients with chronic cor pulmonale and to explore its mechanism by determining the relationship of oxidation/antioxidation system and how such herbs change on the function of endothelial cells and platelets.Methods: Fifty-eight patients were divided into two groups: conventional therapy group (control group
28 patients) and convention plus YQHX herbs group (treated group
30 patients). The control group received conventional management. The treated group were treated with YQHX 150 ml
twice a day
plus the conventional treatment
and the clinical efficacy was recorded. The lipid peroxidation (LPO)
Superoxide dismutase (SOD)
α-granule membrane protein (GMP140)
partial pressure of arterial oxygen (PaO2)
partial pressure of carbon dioxide in artery (PaCO2) and circulating endothelial cells (CEO were measured respectively before and after treatment
and the relationship between various parameters were analyzed. The results were compared with those of 10 healthy subjects got at the same period.Results: (1) The effective rate and PaO2 of the treated group was higher than that of the control group and there were no difference in PaCO2 between the two groups. (2) The levels of LPO
GMP140
CEC in all the patients before therapy were significantly higher than those of the healthy group
and there were marked decrease in the levels of those after treatment (all P<0.01). On the contrary
the levels of SOD in all the patients before therapy were markedly lower than those in the healthy subjects and increased after treatment
P<0.01. (3) The increase of SOD in the treated group was significantly more obvious than that of the control group. In the treated group
the decrease of LPO
GMP140
CEC were markedly more obvious than those in the control group (all P<0. 01). (4) The number of CEC
as well as GMP140
was negatively correlated to PaO2 (P<0.01) and SOD (P< 0.01)
which was positively correlated to LPO (P<0.01). There was a positive correlation between CEC and GMP140 (P<0.05).Conclusion: YQHX herbs in treating chronic cor pulmonale proved to be effective by balancing the oxidation and antioxidation
protecting the pulmonary endothelial cells and activated platelets and helpful in treating respiratory failure.
Abstract
Objective: To observe the clinical effect of Yiqi Huoxue
YQHX) herbs in treating the patients with chronic cor pulmonale and to explore its mechanism by determining the relationship of oxidation/antioxidation system and how such herbs change on the function of endothelial cells and platelets.Methods: Fifty-eight patients were divided into two groups: conventional therapy group (control group
28 patients) and convention plus YQHX herbs group (treated group
30 patients). The control group received conventional management. The treated group were treated with YQHX 150 ml
twice a day
plus the conventional treatment
and the clinical efficacy was recorded. The lipid peroxidation (LPO)
Superoxide dismutase (SOD)
α-granule membrane protein (GMP140)
partial pressure of arterial oxygen (PaO2)
partial pressure of carbon dioxide in artery (PaCO2) and circulating endothelial cells (CEO were measured respectively before and after treatment
and the relationship between various parameters were analyzed. The results were compared with those of 10 healthy subjects got at the same period.Results: (1) The effective rate and PaO2 of the treated group was higher than that of the control group and there were no difference in PaCO2 between the two groups. (2) The levels of LPO
GMP140
CEC in all the patients before therapy were significantly higher than those of the healthy group
and there were marked decrease in the levels of those after treatment (all P<0.01). On the contrary
the levels of SOD in all the patients before therapy were markedly lower than those in the healthy subjects and increased after treatment
P<0.01. (3) The increase of SOD in the treated group was significantly more obvious than that of the control group. In the treated group
the decrease of LPO
GMP140
CEC were markedly more obvious than those in the control group (all P<0. 01). (4) The number of CEC
as well as GMP140
was negatively correlated to PaO2 (P<0.01) and SOD (P< 0.01)
which was positively correlated to LPO (P<0.01). There was a positive correlation between CEC and GMP140 (P<0.05).Conclusion: YQHX herbs in treating chronic cor pulmonale proved to be effective by balancing the oxidation and antioxidation
protecting the pulmonary endothelial cells and activated platelets and helpful in treating respiratory failure.
关键词
chronic cor pulmonaleYiqi Huoxue herbsfree radical damagevascular endotheliumα-granule membrane protein
Keywords
chronic cor pulmonaleYiqi Huoxue herbsfree radical damagevascular endotheliumα-granule membrane protein
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