Effect of Yuxingeng fluid on myocardial energy metabolism in Wistar rats with acute myocardial infarction

Dong Guo-ju; Liu Jian-gang; Shi Da-zhuo

doi:10.1007/BF02836563

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Effect of Yuxingeng fluid on myocardial energy metabolism in Wistar rats with acute myocardial infarction

Updated：2021-08-27

- Effect of Yuxingeng fluid on myocardial energy metabolism in Wistar rats with acute myocardial infarction
- Chinese Journal of Integrative Medicine Vol. 10, Issue 1, Pages: 52-54(2004)
- Affiliations：
  
  Xiyuan Hospital, China Academy of Traditional Chinese Medicine,Beijing
- Author bio：
- Funds：
  
  The project is supported by National Nature Science Foundation (No. 39870942)
- DOI：10.1007/BF02836563
  CLC：
- Published：2004，
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Guo-ju, D., Jian-gang, L. & Da-zhuo, S. Effect of Yuxingeng fluid on myocardial energy metabolism in Wistar rats with acute myocardial infarction., Chin. J. Integr. Med. 10, 52–54 (2004). https://doi.org/10.1007/BF02836563

Dong Guo-ju, Liu Jian-gang, Shi Da-zhuo. Effect of Yuxingeng fluid on myocardial energy metabolism in Wistar rats with acute myocardial infarction. [J]. Chinese Journal of Integrative Medicine 10(1):52-54(2004)
Guo-ju, D., Jian-gang, L. & Da-zhuo, S. Effect of Yuxingeng fluid on myocardial energy metabolism in Wistar rats with acute myocardial infarction., Chin. J. Integr. Med. 10, 52–54 (2004). https://doi.org/10.1007/BF02836563 DOI：

Dong Guo-ju, Liu Jian-gang, Shi Da-zhuo. Effect of Yuxingeng fluid on myocardial energy metabolism in Wistar rats with acute myocardial infarction. [J]. Chinese Journal of Integrative Medicine 10(1):52-54(2004) DOI： 10.1007/BF02836563.

摘要

Objective: To examine the effect of Yuxingeng fluid

YXGF) on myocardial energy metabolism in Wistar rats with acute myocardial infarction (AMI) by observing the ultrastructure of mitochondria and the enzyme activities of rat myocardial adenosine triphosphate (ATP)

succinate dehydrogenase (SDH)

acid phosphatase (ACP)

alkaline phosphatase (ALP) and the content of glycogen.Methods: AMI models were established by ligature of left anterior descending coronary artery and then the rats with AMI were randomly divided into 7 groups: namely

blank group

model group

sham-operated group

captopil group

high-dose YXGF group

middle-dose YXGF group and low-dose YXGF group. From the next day after modeling

the rats were given YXGF through gastrogavage which lasted for 4 weeks. And then

the ultrastructure of mitochondria was observed by electronic microscope and the enzyme activities of ATP

SDH

ACP

ALP and the content of glycogen were determined.Results: Compared with model group

the other three groups of high-dose YXGF

middle-dose YXGF

low-dose YXGF and captopril group could protect the ultrastructure of mitochondria and significantly increase enzyme activities of ATP

SDH

ACP

ALP and the content of glycogen (P<0.01).Conclusion: YXGF can protect mitochondria and increase myocardial enzyme activities and the content of glycogen

which may be one of the mechanisms intervening in the pathological course of the early ventricular remodeling in rats with AMI.

Abstract

Objective: To examine the effect of Yuxingeng fluid

succinate dehydrogenase (SDH)

acid phosphatase (ACP)

blank group

model group

sham-operated group

captopil group

high-dose YXGF group

middle-dose YXGF group and low-dose YXGF group. From the next day after modeling

the rats were given YXGF through gastrogavage which lasted for 4 weeks. And then

the ultrastructure of mitochondria was observed by electronic microscope and the enzyme activities of ATP

SDH

ACP

ALP and the content of glycogen were determined.Results: Compared with model group

the other three groups of high-dose YXGF

middle-dose YXGF

low-dose YXGF and captopril group could protect the ultrastructure of mitochondria and significantly increase enzyme activities of ATP

SDH

ACP

ALP and the content of glycogen (P<0.01).Conclusion: YXGF can protect mitochondria and increase myocardial enzyme activities and the content of glycogen

which may be one of the mechanisms intervening in the pathological course of the early ventricular remodeling in rats with AMI.

关键词

Yuxingeng fluidacute myocardial infarctionmyocardial energy metabolism

Keywords

Yuxingeng fluidacute myocardial infarctionmyocardial energy metabolism

references

Janice M, Pfeffer Marc A, et al. Progressive ventricular remodeling in rat with myocardial infarction. Am J Physiol 1991;260: 1406–1414.

Liu JG, Shi DZ, Wang XF, et al. Effect of Yuxingeng fluid on early ventricular remodeling after acute myocardial infarction. Chin J Integr Emerg Tradit West Med 2001;3 (8): 76–78.

VandenHoek TL, Shao ZH, Li CQ, et al. Mitochondrial electron transport can become a significant source of oxidative injury in cardiomyocytes. J Mol Cell Cardiol 1997; 29: 2441–2450.

Luc D, Daniel M, Lucy M, et al. Myocardial ischemia and in vitro mitochondrial metabolic efficiency. Mol Cell Biochem 1996;158: 161–169.

Kay L, Saks VA, and Rossi A. Early alteration of the control of mithochondrial function in myocardial ischemia. J Mol Cell Cardiol 1997;29: 3399–3411.

Lew WYW, Chen Z, Guth B, et al. Mechanisms of augmented segment shortening in non-ischemic areas during acute ischemia of the canine left ventricle. Circ Res 1985; 56: 351–358.

Anden Hoek TL. Mitochondrial electron transport can become a significant source of oxidative injury in cardiomyocytes. J Mol Cell Cardiol 1997; 29: 2441–2450.

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Shi Da-zhuo (史大卓) —An outstanding cardiologist of integrative medicine

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Cardiovascular Diseases Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences

Division of Emergency, the Second Clinical College of Guangzhou University of Traditional Chinese Medicine

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Department of Internal Cardiac Medicine, the People’s Hospital of Peking University

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