Effect of Buzhong Yiqi decoction on murine liver damage induced by food allergy

Chen Hong; Dong Yang-shen; Chen Fen-hua; Ji Jing-zhi; Chen Yan-feng; Yikura Y.; Kozo Ueno

doi:10.1007/BF02836564

Your Location：

Home >

Browse articles >

Effect of Buzhong Yiqi decoction on murine liver damage induced by food allergy

Updated：2021-08-27

- Effect of Buzhong Yiqi decoction on murine liver damage induced by food allergy
- Chinese Journal of Integrative Medicine Vol. 10, Issue 1, Pages: 55-58(2004)
- Affiliations：
  
  1. Department of Pediatrics, The Third Hospital Affiliated to Sun Yat-Sen University of Medical Sciences,Guangzhou
  2. Department of Pediatrics, Showa University School of Medicine,Tokyo,Japan
- Author bio：
- Funds：
- DOI：10.1007/BF02836564
  CLC：
- Published：2004，
Scan for full text
Hong, C., Yang-shen, D., Fen-hua, C. et al. Effect of Buzhong Yiqi decoction on murine liver damage induced by food allergy., Chin. J. Integr. Med. 10, 55 (2004). https://doi.org/10.1007/BF02836564

Chen Hong, Dong Yang-shen, Chen Fen-hua, et al. Effect of Buzhong Yiqi decoction on murine liver damage induced by food allergy. [J]. Chinese Journal of Integrative Medicine 10(1):55-58(2004)
Hong, C., Yang-shen, D., Fen-hua, C. et al. Effect of Buzhong Yiqi decoction on murine liver damage induced by food allergy., Chin. J. Integr. Med. 10, 55 (2004). https://doi.org/10.1007/BF02836564 DOI：

Chen Hong, Dong Yang-shen, Chen Fen-hua, et al. Effect of Buzhong Yiqi decoction on murine liver damage induced by food allergy. [J]. Chinese Journal of Integrative Medicine 10(1):55-58(2004) DOI： 10.1007/BF02836564.

摘要

Objective: To investigate the effect of Buzhong Yiqi decoction

BZYQD) on liver damage induced by food allergy in mice.Methods: Nc/Jic strain mice with high levels of serum IgE were sensitized by ovalbumin (OVA)

and then divided into two groups and respectively treated with BZYQD (treated group) or normal saline (model group). Samples of serum

liver tissues and small intestine were collected two weeks later

and another group of non-sensitized mice was set as the normal group. The levels of serum alanine aminotransferase (ALT) were measured with spectrophotometry. The liver tissue and small intestine were stained with hematoxylin and eosin (HE) for pathologic analysis. The liver samples were also subjected to analysis of CD4-T helper cell and cytokine (interleukin-4

IL-4

interleukin-6

IL-6) expression with immunohistochemical (avidin-biotin complex

ABC) method.Results: Serum ALT levels decreased and obvious pathologic improvements were seen in the mice treated with BZYQD. And compared with the model mice

the number of positive cells of IL-4

IL-6 and CD4 cell decreased significantly in those treated with BZYQD.Conclusion: BZYQD can effectively decrease the production of cytokines associated with allergic reaction in the liver of mice thus effective in treating liver damage caused by food allergy.

Abstract

Objective: To investigate the effect of Buzhong Yiqi decoction

BZYQD) on liver damage induced by food allergy in mice.Methods: Nc/Jic strain mice with high levels of serum IgE were sensitized by ovalbumin (OVA)

and then divided into two groups and respectively treated with BZYQD (treated group) or normal saline (model group). Samples of serum

liver tissues and small intestine were collected two weeks later

IL-4

interleukin-6

IL-6) expression with immunohistochemical (avidin-biotin complex

ABC) method.Results: Serum ALT levels decreased and obvious pathologic improvements were seen in the mice treated with BZYQD. And compared with the model mice

the number of positive cells of IL-4

关键词

food allergyLiver DamageBuzhong Yiqi decoction

Keywords

food allergyLiver DamageBuzhong Yiqi decoction

references

Loveless MH. Allergy for corn and its derivatives: experiments with a masked ingestion test for its diagnosis. J Allergy 1950; 21: 500–509.

Heiner DC. Respiratory diseases and food allergy. Ann Allergy 1984;53(10): 657–664.

Sampson HA. The immunopathogenic role of food hypersensitivity in atopic dermatitis. Acta Derm Venereol (Stockh) 1992;(Suppl)176: 34–37.

Andusl T, Bauer J, Gerok W. Effects of cytokines on the liver. Hepatology 1991;13(2): 364–373.

Yikura Y, Iwasaki A, Tsubaki T, et al. Study of liver function in infants with atopic dermatitis using the 13cMethacetin Breath Test. Int Arch Allergy Immunol 1995; 107(1–3): 189–193.

Sakamoto Y, Ueno K, Yofu S, et al. The expression of IL-4, IL-6 and TNF-α in food sensitized mice after oral challenge. Int Arch Allergy Immunol 1999; 118(2 – 4): 226–227.

Suzuki T, Takano I, Nagai F, et al. Suppressive effects of Hochu-Ekki-To, a traditional Chinese medicine, on IgE production and histamine release in mice immunized with ovalbumin. Biol Pharm Bull 1999;22(1): 1180–1184.

Egahira YJ. Bronchial asthma and oriental therapy. Clin Exp Med (Igaku No Ayumi) 1991;159(3): 702–705 (In Japanese).

Kobayashi YG, Mizuno N, Ishi SK, et al. Changes of cytokines during treatment of atopic dermatitis using BZYQD. J J Dermatology 1999; 109(7): 1078 (In Japanese).

Scudamore CL, Thornton EM, McMillan L, et al. Release of the mucosal mast cell granule chymase, rat mast cell protease-II during anaphylaxis is associated with the rapid development of paracellular permeability to macromolecules in rat jejunum. J Exp Med 1995;182(6): 1871–1881.

Hill DJ, Firer MA, Shelton MJ, et al. Manifestations of milk allergy in infancy: clinical and immunologic findings. J Pediatr 1986;109(2): 270–275.

Paul WE, Ohara J. B-cell stimulatory factor-1/interlukin 4. Annu Rev Immunol 1987;5: 5429–5459.

Kaneko M, Kishihara K, Kawakita T, et al. Suppression of IgE production Chinese Medicine, Bu-Zhong-Yi-QiTang (Japanese name: Hochu-ekki-to). Immunopharmacology 1997;36(2): 79–85.

FULL TEXT LINK

More>

Views

370

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Effect of Radix Salviae Miltiorrhizae on production of free radical products from lung during cardiopulmonary bypass operation

Related Author

No data

Related Institution

Cardiovascular Surgery Department of Affiliated union Hospital, Fujian Medical College

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰