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Clinical study of Gushen tablet in reducing children’s nephrotic syndrome relapse
- Chinese Journal of Integrative Medicine Vol. 9, Issue 3, Pages: 185-190(2003)
- Affiliations：
1. The First Affiliated Hospital, Henan College of TCM,Zhengzhou
2. Henan Academy of TCM,China
3. Hospital of Henan TCM College,China
4. Zhengzhou City Children Hospital,China
- Author bio：
- Funds：The item was supported by the Science and Technology Department of Henan Province (No. 941200528)
DOI：10.1007/BF02838029
CLC：Published：2003，
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Ying, Y., Ya, G., Yu-hong, M. et al. Clinical study of Gushen tablet in reducing children’s nephrotic syndrome relapse., Chin. J. Integr. Med. 9, 185–190 (2003). https://doi.org/10.1007/BF02838029
Yun Ying, Gao Ya, Ma Yu-hong, et al. Clinical study of Gushen tablet in reducing children’s nephrotic syndrome relapse. [J]. Chinese Journal of Integrative Medicine 9(3):185-190(2003)
Ying, Y., Ya, G., Yu-hong, M. et al. Clinical study of Gushen tablet in reducing children’s nephrotic syndrome relapse., Chin. J. Integr. Med. 9, 185–190 (2003). https://doi.org/10.1007/BF02838029 DOI：
Yun Ying, Gao Ya, Ma Yu-hong, et al. Clinical study of Gushen tablet in reducing children’s nephrotic syndrome relapse. [J]. Chinese Journal of Integrative Medicine 9(3):185-190(2003) DOI： 10.1007/BF02838029.
摘要
Objective: To explore the effect of Gushen tablet (GST) in reducing the relapse of children’s nephrotic syndrome and the possible mechanism of drugs used.Methods: Fifty children with primary nephrotic syndrome who had been induced and alleviated with regular glucocorticoid (GC) were randomly divided into two groups: the GST group used GST and standard middle-long term course of GC
and the control group adopted standard middle-long term course of GC and immunoinhibitory or immunomodulatory agents for treatment. The 0. 5
1 and 2 years after the treatment the relapse episodes
time for urinary protein negative conversion after relapse
the episodes of patients infection and relapse after infection were evaluated. Before and after treatment the plasma cortisol and T lymphocyte subpopulation were determined.Results: The relapse rate of GST group: the rates after 0. 5
1
2 years were 20. 0%
30. 0% and 40. 9%
and the frequent relapse rate were 0
6. 7% and 9. 2% respectively
which were lower than those of control group (60. 0%
70. 0%
69. 2% and 25. 0%
15. 0%
15. 4% respectively); in the GST group no relapse occurred within 0. 5 year
the relapse rate after 1 and 2 years reduced by 40. 0% and 28. 3%
compared with those of the control group (allP < 0.05); during the observation period
the mean infection/every child patient was 1. 86 episodes in GST group
after infection the nephrotic relapse rate was 28. 3%
which was lower than that of the control group (2. 25 episodes
71.1%
P < 0.05); the relapse per patient in GST group was 0. 8 episodes
time for urinary protein negative conversion was 12. 00± 8. 98 days
lower than those of control group (1. 6 episodes
20. 75±11. 95 days
P < 0. 05); 3 months after GST treatment the plasma cortisol level normalized
and the CD4/CD8 ratio elevated (P < 0.05).Conclusion: GST could possibly reduce the relapse of children nephrosis
and the frequent relapse and relapse episodes
and the time for post-relaptic urinary protein negative conversion shortened
the plasma cortisol elevated
and the adjustment of cellular immunity disturbance promoted.
Abstract
Objective: To explore the effect of Gushen tablet (GST) in reducing the relapse of children’s nephrotic syndrome and the possible mechanism of drugs used.Methods: Fifty children with primary nephrotic syndrome who had been induced and alleviated with regular glucocorticoid (GC) were randomly divided into two groups: the GST group used GST and standard middle-long term course of GC
and the control group adopted standard middle-long term course of GC and immunoinhibitory or immunomodulatory agents for treatment. The 0. 5
1 and 2 years after the treatment the relapse episodes
time for urinary protein negative conversion after relapse
the episodes of patients infection and relapse after infection were evaluated. Before and after treatment the plasma cortisol and T lymphocyte subpopulation were determined.Results: The relapse rate of GST group: the rates after 0. 5
1
2 years were 20. 0%
30. 0% and 40. 9%
and the frequent relapse rate were 0
6. 7% and 9. 2% respectively
which were lower than those of control group (60. 0%
70. 0%
69. 2% and 25. 0%
15. 0%
15. 4% respectively); in the GST group no relapse occurred within 0. 5 year
the relapse rate after 1 and 2 years reduced by 40. 0% and 28. 3%
compared with those of the control group (allP < 0.05); during the observation period
the mean infection/every child patient was 1. 86 episodes in GST group
after infection the nephrotic relapse rate was 28. 3%
which was lower than that of the control group (2. 25 episodes
71.1%
P < 0.05); the relapse per patient in GST group was 0. 8 episodes
time for urinary protein negative conversion was 12. 00± 8. 98 days
lower than those of control group (1. 6 episodes
20. 75±11. 95 days
P < 0. 05); 3 months after GST treatment the plasma cortisol level normalized
and the CD4/CD8 ratio elevated (P < 0.05).Conclusion: GST could possibly reduce the relapse of children nephrosis
and the frequent relapse and relapse episodes
and the time for post-relaptic urinary protein negative conversion shortened
the plasma cortisol elevated
and the adjustment of cellular immunity disturbance promoted.
关键词
Gushen tabletchildren nephrotic syndromerelapseadrenocortical functionT lymphocyte subpopulation
Keywords
Gushen tabletchildren nephrotic syndromerelapseadrenocortical functionT lymphocyte subpopulation
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