Effect of acupuncture on uncoupling protein 1 gene expression for brown adipose tissue of obese rats

Liu Zhi-cheng; Sun Feng-min; Zhao Dong-hong; Zhang Zhong-cheng; Sun Zhi; Wu Hai-tao; Xu Bing-guo; Zhu Miao-hua; Li Chao-jun

doi:10.1007/BF02838034

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Effect of acupuncture on uncoupling protein 1 gene expression for brown adipose tissue of obese rats

Updated：2021-08-27

- Effect of acupuncture on uncoupling protein 1 gene expression for brown adipose tissue of obese rats
- Chinese Journal of Integrative Medicine Vol. 9, Issue 3, Pages: 204-209(2003)
- Affiliations：
  
  1. Nanjing University of TCM,Nanjing
  2. Nanjing Population Administration College,China
  3. Nanjing Normal University,China
- Author bio：
- Funds：
  
  The item is supported by the National Nature Science Foundation (No. 39970923)
- DOI：10.1007/BF02838034
  CLC：
- Published：2003，
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Zhi-cheng, L., Feng-min, S., Dong-hong, Z. et al. Effect of acupuncture on uncoupling protein 1 gene expression for brown adipose tissue of obese rats., Chin. J. Integr. Med. 9, 204–209 (2003). https://doi.org/10.1007/BF02838034

Liu Zhi-cheng, Sun Feng-min, Zhao Dong-hong, et al. Effect of acupuncture on uncoupling protein 1 gene expression for brown adipose tissue of obese rats. [J]. Chinese Journal of Integrative Medicine 9(3):204-209(2003)
Zhi-cheng, L., Feng-min, S., Dong-hong, Z. et al. Effect of acupuncture on uncoupling protein 1 gene expression for brown adipose tissue of obese rats., Chin. J. Integr. Med. 9, 204–209 (2003). https://doi.org/10.1007/BF02838034 DOI：

Liu Zhi-cheng, Sun Feng-min, Zhao Dong-hong, et al. Effect of acupuncture on uncoupling protein 1 gene expression for brown adipose tissue of obese rats. [J]. Chinese Journal of Integrative Medicine 9(3):204-209(2003) DOI： 10.1007/BF02838034.

摘要

Objective; To explore the effects of acupuncture on the expression of uncoupling protein 1 (UCP1) gene of brown adipose tissue (BAT) in obese rats.Methods: The expression of UCP1 gene of BAT was determined with RT-PCR technique. The changes of body weight

Lee’s index

body fat

and the expression of UCP1 gene of BAT in obese rats were observed before and after acupuncture.Results: The body weight

Lee’s index

body fat in obese rats were all markedly higher than those in normal rats

but the expression of UCP1 gene of BAT in obese rats was all lower than that in normal rats. There were negative correlation between the obesity index and the expression of UCP1 gene in BAT. After acupuncture the marked effect of weight loss was achieved while the expression of UCP1 gene of BAT obviously increased in obese rats.Conclusion: The abnormal reduction for expression of UCP1 gene of BAT might be an important cause for the obesity. To promote the expression of UCP1 in obese organism might be an important cellular and molecular mechanism in anti-obesity effect by acupuncture.

Abstract

Lee’s index

body fat

and the expression of UCP1 gene of BAT in obese rats were observed before and after acupuncture.Results: The body weight

Lee’s index

body fat in obese rats were all markedly higher than those in normal rats

关键词

acupunctureobesityuncoupling proteingene

Keywords

acupunctureobesityuncoupling proteingene

references

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LIU ZC, SUN FM, ZHAO DH, et al. Effect of acupuncture on simple obesity leptin and insulin resistance. Acad J TCM 2003, 23(1): 15–18.

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Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University

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Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences

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