Objective: To examine the therapeutic mechanism of Yuxingeng liquid (YXGL) on early ventricular remodeling in Wistar rats with acute myocardial infarction(AMI).Methods: Measuring the cardiac index (CI)

left ventricular weight (LVW) and cardiac myocyte dimension and observing the concentration of endothelin (ET) and angiotensin II (Ang II) in the plasma and myocardium. AMI models were established by ligature of left anterior descending coronary artery and the rats with AMI were randomly divided into 6 groups: the model group

sham-operation group

captopril group

high dosage YXGL group

middle dosage YXGL group and low dosage YXGL group. From the next day after modeling

the rats had been given YXGL through the gastric tube

which lasted for 4 weeks. And then

CI

LVW and concentration of ET and Ang II in the plasma and myocardium were tested.Results: Comparing with model control group

high dosage YXGL

middle dosage YXGL and captopril can all significantly reduce CI

LVW

cardiac cell dimension and content of ET and Ang II in both plasma and myocardium (P < 0.05 orP < 0.01).Conclusion: YXGL can remarkably reduce LVW

CI and concentration of ET and Ang II

and lowering the concentration of ET and Ang II is possibly one of the mechanisms intervening the pathological course of the early ventricular remodeling in rats with AMI.