Study on Treatment of polycystic ovarian syndrome with Infertility by combined therapy of Chinese herbal medicine and compound cyproterone acetate

Tao Li-li; Chen Xiao-ping; Gu Zheng-tian

doi:10.1007/BF02838558

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Study on Treatment of polycystic ovarian syndrome with Infertility by combined therapy of Chinese herbal medicine and compound cyproterone acetate

Updated：2021-08-27

- Study on Treatment of polycystic ovarian syndrome with Infertility by combined therapy of Chinese herbal medicine and compound cyproterone acetate
- Chinese Journal of Integrative Medicine Vol. 9, Issue 2, Pages: 98-103(2003)
- Affiliations：
  
  1. Department of Gynecology, The First Affiliated Hospital of Guangzhou University of TCM,Guangzhou
  2. Guangdong Provincial Second TCM Hospital,China
  3. Guangzhou Municipal First People’s Hospital,China
- Author bio：
- Funds：
- DOI：10.1007/BF02838558
  CLC：
- Published：2003，
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Li-li, T., Xiao-ping, C. & Zheng-tian, G. Study on Treatment of polycystic ovarian syndrome with Infertility by combined therapy of Chinese herbal medicine and compound cyproterone acetate., Chin. J. Integr. Med. 9, 98–103 (2003). https://doi.org/10.1007/BF02838558

Tao Li-li, Chen Xiao-ping, Gu Zheng-tian. Study on Treatment of polycystic ovarian syndrome with Infertility by combined therapy of Chinese herbal medicine and compound cyproterone acetate. [J]. Chinese Journal of Integrative Medicine 9(2):98-103(2003)
Li-li, T., Xiao-ping, C. & Zheng-tian, G. Study on Treatment of polycystic ovarian syndrome with Infertility by combined therapy of Chinese herbal medicine and compound cyproterone acetate., Chin. J. Integr. Med. 9, 98–103 (2003). https://doi.org/10.1007/BF02838558 DOI：

Tao Li-li, Chen Xiao-ping, Gu Zheng-tian. Study on Treatment of polycystic ovarian syndrome with Infertility by combined therapy of Chinese herbal medicine and compound cyproterone acetate. [J]. Chinese Journal of Integrative Medicine 9(2):98-103(2003) DOI： 10.1007/BF02838558.

摘要

Objective: To evaluate the effect of combined therapy of Chinese herbal medicine and compound cyproterone acetate (CPA) in treating non-obesity polycystic ovarian syndrome (PCOS) and to explore its mechanism in improving withdrawal ovulation.Methods: Eighty-six patients of non-obesity PCOS

typed as Shen-deficiency with blood stasis Syndrome or Shen-deficiency with Phlegm-Dampness Syndrome by Syndrome Differentiation in traditional Chines medicine

were randomly divided into three groups: (1) The TCM group (n=26) was treated with Chinese drugs for 6 menstrual cycles; (2) The western medicine (WM) group (n=30) was treated with 1 tablet of CPA for 21 days

with the treatment beginning from the 5th day of menstruation. The treatment was given for 3 menstrual cycles by repetitious medication

which stopped and restarted on the 5th day of withdrawal bleeding. Then the ovulation promoting therapy was applied by using clomifene citrate and human chorionic gonadotropin (CC/hCG) for 3 menstrual cycles; (3) The TCM-WM group (n=30) was treated with the medications used for the above two groups. The menstrual cycle

the volume and duration of the menstruation

as well as the improvement of acne and pilosis [Ferrinian-Gallway (F-G) scoring] were observed after 3 cycles ended. Moreover

condition of ovulation was monitored by B-ultrasonography at the 4th-6th cycle and status of pregnancy was observed.Results: Compared with before treatment

the blood level of luteinizing hormone (LH) and testosterone (T) in all 3 groups after treatment significantly decreased (P<0.05)

with its ratio to follicle-stimulating hormone (LH/FSH) recovered to normal

but without markedly change in levels of FSH

estradiol (E2) and prolactin (PRL). The menstrual cycle in most patients got regular and acne significantly alleviated (P<0.05)

and the improvement of infrequent menstruation and acne was better in the WM group and the TCM-WM group than that in the TCM group

but pilosis showed no significant improvement in all three groups. The periodical ovulation rate in the TCM-WM group (73.1%) and the WM group (68.3%) was significantly higher than that in the TCM group (40%). The pregnancy rate in the TCM-WM group (53.8%) was significantly higher than that in the other two groups (26.1% and 25% respectively

all P<0.05).Conclusion: Using combined therapy of TCM and composite CPA followed by ovulation promoting agents of TCM and WM to treat patients of non-obesity PCOS could relieve the clinical symptoms

improve the abnormal blood level of sex hormones and significantly elevate the pregnancy rate.

Abstract

typed as Shen-deficiency with blood stasis Syndrome or Shen-deficiency with Phlegm-Dampness Syndrome by Syndrome Differentiation in traditional Chines medicine

with the treatment beginning from the 5th day of menstruation. The treatment was given for 3 menstrual cycles by repetitious medication

the volume and duration of the menstruation

as well as the improvement of acne and pilosis [Ferrinian-Gallway (F-G) scoring] were observed after 3 cycles ended. Moreover

condition of ovulation was monitored by B-ultrasonography at the 4th-6th cycle and status of pregnancy was observed.Results: Compared with before treatment

the blood level of luteinizing hormone (LH) and testosterone (T) in all 3 groups after treatment significantly decreased (P<0.05)

with its ratio to follicle-stimulating hormone (LH/FSH) recovered to normal

but without markedly change in levels of FSH

estradiol (E2) and prolactin (PRL). The menstrual cycle in most patients got regular and acne significantly alleviated (P<0.05)

and the improvement of infrequent menstruation and acne was better in the WM group and the TCM-WM group than that in the TCM group

all P<0.05).Conclusion: Using combined therapy of TCM and composite CPA followed by ovulation promoting agents of TCM and WM to treat patients of non-obesity PCOS could relieve the clinical symptoms

improve the abnormal blood level of sex hormones and significantly elevate the pregnancy rate.

关键词

Infertilitypolycystic ovarian syndromeintegrated traditional and western medicine therapy

Keywords

Infertilitypolycystic ovarian syndromeintegrated traditional and western medicine therapy

references

LI MZ, edit. Gynecologic endocrinology. 1st edition. Beijing: People’s Publishing House of Military Medicine, 2001: 202.

Ministry of Health. Principal Guidance on Clinical Researches of New Chinese Drugs. 1st ed., 1993; 276–280.

XIA GC, edit. Infertility and conditioning in menstrual period. 1st edition. Beijing: Publishing House of People’s Health, 2000: 233–261.

CHENG J, edit. Theoretical and practical progress of integrated traditional Chinese and western medicine on reproduction. 1st edition. Macao: Publishing House of International Yanhuang Culture, 2000: 6–10.

LIANG XY, ZHUANG GL, ZHOU CQ, et al. Treatment to 47 patients of polycystic ovarian syndrome by compound cyproterone acetate. Chin J Gyneocol and Obste 1999; 34(4): 246–247.

Scheen AJ, Jandrain BJ, Hunblet DM, et al. Effects of 1year treatment with a low-dose combined oral contraceptive containing ethinyl estradial and cyproterone acetate on glucose and insulin metabolism. Fertil Steril 1993; 59: 797–802.

Gerhard I, Metthes J, Runnebaum B. The induction of ovulation with pulsatile GnRH administration in hyperandrogenic woman after down-regulation with buserelin or suppression with an oral contraceptive. Hum Reprod 1993; 8: 2033–2038.

TAO Y, DAI Q, ZHANG DY, et al. Study on treatment to patients of polycystic ovarian syndrome and infertility with clomifene resistance by compound cyproterone acetate. Chin J Gynecol and Obste 1999; 34(9): 528–532.

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