Effect of Qingre Buyi Decoction on nitric oxide and histomorphology of intestinal mucosa in rats with radiation enteritis

Ding Xiao-fan; Li De-xing; Zhao Lin

doi:10.1007/BF02838564

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Effect of Qingre Buyi Decoction on nitric oxide and histomorphology of intestinal mucosa in rats with radiation enteritis

Updated：2021-08-27

- Effect of Qingre Buyi Decoction on nitric oxide and histomorphology of intestinal mucosa in rats with radiation enteritis
- Chinese Journal of Integrative Medicine Vol. 9, Issue 2, Pages: 120-123(2003)
- Affiliations：
  
  Provincial Center of Radiation Oncology, Gansu Academy of Medical Sciences,Lanzhou
- Author bio：
- Funds：
- DOI：10.1007/BF02838564
  CLC：
- Published：2003，
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Xiao-fan, D., De-xing, L. & Lin, Z. Effect of Qingre Buyi Decoction on nitric oxide and histomorphology of intestinal mucosa in rats with radiation enteritis., Chin. J. Integr. Med. 9, 120–123 (2003). https://doi.org/10.1007/BF02838564

Ding Xiao-fan, Li De-xing, Zhao Lin. Effect of Qingre Buyi Decoction on nitric oxide and histomorphology of intestinal mucosa in rats with radiation enteritis. [J]. Chinese Journal of Integrative Medicine 9(2):120-123(2003)
Xiao-fan, D., De-xing, L. & Lin, Z. Effect of Qingre Buyi Decoction on nitric oxide and histomorphology of intestinal mucosa in rats with radiation enteritis., Chin. J. Integr. Med. 9, 120–123 (2003). https://doi.org/10.1007/BF02838564 DOI：

Ding Xiao-fan, Li De-xing, Zhao Lin. Effect of Qingre Buyi Decoction on nitric oxide and histomorphology of intestinal mucosa in rats with radiation enteritis. [J]. Chinese Journal of Integrative Medicine 9(2):120-123(2003) DOI： 10.1007/BF02838564.

摘要

Objective: To explore the mechanism of Qingre Buyi Decoction (QBD) in prevention and treatment of radiation enteritis in rats.Methods: Forty-eight Wistar rats were randomly divided into four groups

the TCM group

the WM group

the model group and the control group

12 in each group. Rats in the former three groups were given orally with QBD

norfloxacin and normal saline once a day for 7 successive days

after being irradiated with X-ray at single dose of 10 Gy for modeling of radiation enteritis

while rats in the control group were untreated. Animals were sacrificed at the end of the medication. NO concentration

mean height and number of villi per centimeter in their small intestinal mucosa were measured.Results: The intestinal NO concentration was significantly lower in the TCM and WM groups than that in the model group(P<0.05)

while the number of villi was significantly more and the height higher in the former two groups than those in the model group (P<C0.01 for both)

but no significant difference was shown between the TCM group and the WM group.Conclusion: QBD could inhibit the production of NO

increase the number and height of intestinal villi in rats with radiation enteritis

suggesting that it could reduce the inflammatory reaction of intestinal mucosa to irradiation

protect mucosa from radiation damage

and promote the regeneration of mucosa.

Abstract