Effect of Kaiyu Qingwei granule on insulin receptor in liver and skeletal muscular cell membrane in diabetes mellitus rats

Liu Hong-fang; Tong Xiao-lin; Wang Qmg-guo; Zuo Ping-ping; Guo An-chen; Liu Hong-xing

doi:10.1007/BF02838569

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Effect of Kaiyu Qingwei granule on insulin receptor in liver and skeletal muscular cell membrane in diabetes mellitus rats

Updated：2021-08-27

- Effect of Kaiyu Qingwei granule on insulin receptor in liver and skeletal muscular cell membrane in diabetes mellitus rats
- Chinese Journal of Integrative Medicine Vol. 9, Issue 2, Pages: 132-135(2003)
- Affiliations：
  
  1. Beijing University of TCM,Beijing
  2. Japan Friendship Hospital, China,China
  3. Chinese Academy of Medical Sciences, Peking Union Medical College,China
- Author bio：
- Funds：
- DOI：10.1007/BF02838569
  CLC：
- Published：2003，
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Hong-fang, L., Xiao-lin, T., Qmg-guo, W. et al. Effect of Kaiyu Qingwei granule on insulin receptor in liver and skeletal muscular cell membrane in diabetes mellitus rats., Chin. J. Integr. Med. 9, 132–135 (2003). https://doi.org/10.1007/BF02838569

Liu Hong-fang, Tong Xiao-lin, Wang Qmg-guo, et al. Effect of Kaiyu Qingwei granule on insulin receptor in liver and skeletal muscular cell membrane in diabetes mellitus rats. [J]. Chinese Journal of Integrative Medicine 9(2):132-135(2003)
Hong-fang, L., Xiao-lin, T., Qmg-guo, W. et al. Effect of Kaiyu Qingwei granule on insulin receptor in liver and skeletal muscular cell membrane in diabetes mellitus rats., Chin. J. Integr. Med. 9, 132–135 (2003). https://doi.org/10.1007/BF02838569 DOI：

Liu Hong-fang, Tong Xiao-lin, Wang Qmg-guo, et al. Effect of Kaiyu Qingwei granule on insulin receptor in liver and skeletal muscular cell membrane in diabetes mellitus rats. [J]. Chinese Journal of Integrative Medicine 9(2):132-135(2003) DOI： 10.1007/BF02838569.

摘要

Objective: To investigate the effect of Kaiyu Qingwei granule (KYQWG) on the insulin binding capacity of liver and skeletal muscular cell membrane and serum insulin-like growth factor-1 (IGF-1) in streptozotocin-induced diabetic rats.Methods: Rats in four experimental groups were investigated: the control group

the model group

the KYQWG group and the Metformin group. The insulin binding rate (IBR) of liver and skeletal muscular cell membrane was detected by receptor-ligand radiometric method and changes of serum levels of glucose

insulin and IGF-1 were observed before and after 4 weeks of medication.Results: The KYQWG group had a lower blood glucose level and IBR of liver and muscular cell membrane

as compared with those in the model group (P<0.01 or P<0.05)

and a higher level of IGF-1 than that in the model group(P<0.01)

but had no obvious changes in the serum level of insulin.Conclusion: KYQWG may increase the serum level of IGF-1 in diabetic rats

thus to decrease the insulin resistance at ante-receptor sites and improve the sugar metabolic disturbance in rats with diabetes mellitus.

Abstract

the model group

insulin and IGF-1 were observed before and after 4 weeks of medication.Results: The KYQWG group had a lower blood glucose level and IBR of liver and muscular cell membrane

as compared with those in the model group (P<0.01 or P<0.05)

and a higher level of IGF-1 than that in the model group(P<0.01)

but had no obvious changes in the serum level of insulin.Conclusion: KYQWG may increase the serum level of IGF-1 in diabetic rats

thus to decrease the insulin resistance at ante-receptor sites and improve the sugar metabolic disturbance in rats with diabetes mellitus.

关键词

Kaiyu Qingwei granulediabetes mellitusInsulin Receptorinsulin-like growth factor-1rat

Keywords

Kaiyu Qingwei granulediabetes mellitusInsulin Receptorinsulin-like growth factor-1rat

references

TONG XL. LIU HF, PIAO XY. Clinical study on effect of Kaiyu Qingwei granule on insulin resistance in patients with type 2 diabetes mellitus. Applied internal medicine journal of herbalist doctor 2001; 15(2): 10–11.

Klip A, Walker D. The glucose transport system of muscle plasma membranes: characterization by means of3H cytochalasin B binding. Arch Biochem Biophy 1983; 221 (1) : 175 -187.

Nishimura H, Kuzuya H, Okamoto M, et al. Postreceptor defect in insulin action in streptozotocin-induced diabetic rat. Am J Physiol 1989; 256E: 624–630.

Hopkins KD, Holdaway IM. Insulin secretion and insulin-like growth factor-1 levels in active and controlled acromegaly. Clinic Endocrin 1992; 36: 53–57.

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Shandong University of Traditional Chinese Medicine

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Class II Laboratory of Acupuncture Quantity-Effect Relationship Affiliated to the State, Administration of Traditional Chinese Medicine

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