Experimental study on effect of Compound Biejia Ruangan prescription on high-resolution computerized tomographic images in bleomycin induced pulmonary fibrosis rats

Zhang Dong-wei; Wang Ji-feng; Niu Jian-zhao; Gao Bao-hua; Li Gong-yu

doi:10.1007/BF02838613

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Experimental study on effect of Compound Biejia Ruangan prescription on high-resolution computerized tomographic images in bleomycin induced pulmonary fibrosis rats

Updated：2021-08-27

- Experimental study on effect of Compound Biejia Ruangan prescription on high-resolution computerized tomographic images in bleomycin induced pulmonary fibrosis rats
- Chinese Journal of Integrative Medicine Vol. 9, Issue 4, Pages: 270-275(2003)
- Affiliations：
  
  The Cell and Biochemistry Laboratory of Beijing University of Chinese Medicine,Beijing
- Author bio：
- Funds：
  
  This study was supported by National Funds of Natural Science (No. 30130220) and Administration of Education against SARS(No. 15)
- DOI：10.1007/BF02838613
  CLC：
- Published：2003，
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Dong-wei, Z., Ji-feng, W., Jian-zhao, N. et al. Experimental study on effect of Compound Biejia Ruangan prescription on high-resolution computerized tomographic images in bleomycin induced pulmonary fibrosis rats., Chin. J. Integr. Med. 9, 270–275 (2003). https://doi.org/10.1007/BF02838613

Zhang Dong-wei, Wang Ji-feng, Niu Jian-zhao, et al. Experimental study on effect of Compound Biejia Ruangan prescription on high-resolution computerized tomographic images in bleomycin induced pulmonary fibrosis rats. [J]. Chinese Journal of Integrative Medicine 9(4):270-275(2003)
Dong-wei, Z., Ji-feng, W., Jian-zhao, N. et al. Experimental study on effect of Compound Biejia Ruangan prescription on high-resolution computerized tomographic images in bleomycin induced pulmonary fibrosis rats., Chin. J. Integr. Med. 9, 270–275 (2003). https://doi.org/10.1007/BF02838613 DOI：

Zhang Dong-wei, Wang Ji-feng, Niu Jian-zhao, et al. Experimental study on effect of Compound Biejia Ruangan prescription on high-resolution computerized tomographic images in bleomycin induced pulmonary fibrosis rats. [J]. Chinese Journal of Integrative Medicine 9(4):270-275(2003) DOI： 10.1007/BF02838613.

摘要

Objective: To study the therapeutic effect of Compound Biejia Ruangan prescription (CBRP) on rat model with pulmonary fibrosis induced by bleomycin.Methods: Fifty-four male Sprague-Dawley rats were randomly divided into 6 groups (9 rats in each group). From the first day to the 28th day of the experiment

except to those in the sham-model control group that were treated with normal saline

the same amount of bleomycin injection as the normal saline given to the control group was given through endotracheal instillation to all the rats in all the other groups. From the 29th day of the modeling

CBRP solution of different dosages was respectively injected into the rats in the high

moderate and low CBRP dose group

while equal volume of normal saline was given to those in the sham-model control group and the model control group

and an equal volume of prednisone solution was given to rats in the prednisone group. On the 80th day

the high-resolution computerized tomographic (HRCT) images were observed on an equal footing

and HRCT-pathology was correlatively studied.Results: Different HRCT pathological changes were shown in the rats with pulmonary fibrosis

such as lung consolidation

thickening of interlobular septum and interlobular mesenchyma as well as lobular deformation

nodule shadow

abnormal brochiovascular tract

thickened pleura with irregular junction and polished glass-like dense shadows. Honeycomb lung was observed in some cases. Pathological sections showed fibrotic proliferation of lung tissues and noticeable pulmonary interstitial fibrosis. CBRP could improve HRCT images of rats with pulmonary fibrosis

and lower fibrotic proliferation of the lung tissue.Conclusion: CBRP plays its therapeutic role possibly through its effect on the structure of the lung in rats with pulmonary fibrosis.

Abstract

except to those in the sham-model control group that were treated with normal saline

CBRP solution of different dosages was respectively injected into the rats in the high

moderate and low CBRP dose group

while equal volume of normal saline was given to those in the sham-model control group and the model control group

and an equal volume of prednisone solution was given to rats in the prednisone group. On the 80th day

the high-resolution computerized tomographic (HRCT) images were observed on an equal footing

and HRCT-pathology was correlatively studied.Results: Different HRCT pathological changes were shown in the rats with pulmonary fibrosis

such as lung consolidation

thickening of interlobular septum and interlobular mesenchyma as well as lobular deformation

nodule shadow

abnormal brochiovascular tract

and lower fibrotic proliferation of the lung tissue.Conclusion: CBRP plays its therapeutic role possibly through its effect on the structure of the lung in rats with pulmonary fibrosis.

关键词

Compound Biejia Ruangan prescriptionratsPulmonary Fibrosishigh-resolution computerizd tomography

Keywords

Compound Biejia Ruangan prescriptionratsPulmonary Fibrosishigh-resolution computerizd tomography

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Guangzhou University of Traditional Chinese Medicine

Jinan University

Nephropathy of Chinese PLA General Hospital, State Discipline and Key Laboratory of Kidney Disease (Chinese PLA General Hospital 2011DAV)

Department of Geriatrics, Fuzhou General Hospital of Nanjing Military District

Research Center of Rehabilitation Science and Technology, School of Life Science and Technology, Xi’an Jiaotong University

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