Effect of Gengnianchun Recipe on bone mineral density, bone biomechanical parameters and serum lipid level in ovariectomized rats

Liu Ke-ju; Wang Wen-jun; Li Da-jin; Jin Hui-fang; Zhou Wen-jiang

doi:10.1007/BF02857360

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Effect of Gengnianchun Recipe on bone mineral density, bone biomechanical parameters and serum lipid level in ovariectomized rats

Updated：2021-08-27

- Effect of Gengnianchun Recipe on bone mineral density, bone biomechanical parameters and serum lipid level in ovariectomized rats
- Chinese Journal of Integrative Medicine Vol. 12, Issue 2, Pages: 132-136(2006)
- Affiliations：
  
  1. Obstetrics and Gynecology Hospital, Fudan University,Shanghai
  2. Radiology Institute of Fudan University,Shanghai
  3. Department of Experimental, Animal of Fudan University,Shanghai
- Author bio：
- Funds：
  
  Supported by Shanghai Funds for Gynecology of Integrated Traditional and Western Medicine (No. 96-III-001), the National Natural Science Foundation of China (No. 30472259), Shanghai Scientific Funds for Integrated Traditional and Western Medicine (No. 2004L020A).
- DOI：10.1007/BF02857360
  CLC：
- Published：2006，
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Ke-ju, L., Wen-jun, W., Da-jin, L. et al. Effect of Gengnianchun Recipe on bone mineral density, bone biomechanical parameters and serum lipid level in ovariectomized rats., Chin. J. Integr. Med. 12, 132–136 (2006). https://doi.org/10.1007/BF02857360

Liu Ke-ju, Wang Wen-jun, Li Da-jin, et al. Effect of Gengnianchun Recipe on bone mineral density, bone biomechanical parameters and serum lipid level in ovariectomized rats. [J]. Chinese Journal of Integrative Medicine 12(2):132-136(2006)
Ke-ju, L., Wen-jun, W., Da-jin, L. et al. Effect of Gengnianchun Recipe on bone mineral density, bone biomechanical parameters and serum lipid level in ovariectomized rats., Chin. J. Integr. Med. 12, 132–136 (2006). https://doi.org/10.1007/BF02857360 DOI：

Liu Ke-ju, Wang Wen-jun, Li Da-jin, et al. Effect of Gengnianchun Recipe on bone mineral density, bone biomechanical parameters and serum lipid level in ovariectomized rats. [J]. Chinese Journal of Integrative Medicine 12(2):132-136(2006) DOI： 10.1007/BF02857360.

摘要

Objective: To observe the effect of Gengnianchun Recipe (GNC) on bone mineral density (BMD)

bone biomechanical parameters and serum lipid level in the bilaterally ovariectomized (OVX) rats and to explore the prophylactic and therapeutic action of GNC on ovariectomy induced osteoporosis and hyperlipidemia.Methods: OVX SD rats

10 –12 months old

were divided into different groups and fed with GNC 2 g/d

GNC 1 g/d and Nilestriol 0. 125 mg/week

respectively for 4 months to observe the change of BMD and bone biomechanical parameters of the lumbar vertebrae

and the serum levels of total cholesterol (TC)

triglyceride(TG)

high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C)

and to compare the effect of the two drugs on the morphology of the uterus.Results: There was marked reduction in BMD and biomechanical parameters in lumbar vertebrae (P< 0.01) and increase of serum TC and LDL-C levels (P< 0. 01) in rats after OVX. GNC or Nilestriol significantly improved the decreased BMD and biomechanical parameters of the lumbar vertebrae (P< 0.05 orP< 0.01)

and reduced the serum TC and LDL-C levels (P< 0.01). In the Nilestriol group

the wet weight of uterus got increased obviously (P< 0.01)

the number of uterine glands increased

uterine columnar epithelium thickened

and the mitotic figures in the epithelial stroma and myointimal cells augmented. But no such effect in wet weight and morphology of uterus was found in the GNC group.Conclusion: GNC could increase the BMD and biomechanical parameters of the lumbar vertebrae

reduce the serum TC and LDL-C levels

yet produce no adverse reaction in stimulating proliferation and hypertrophy of uterus.

Abstract

Objective: To observe the effect of Gengnianchun Recipe (GNC) on bone mineral density (BMD)

10 –12 months old

were divided into different groups and fed with GNC 2 g/d

GNC 1 g/d and Nilestriol 0. 125 mg/week

respectively for 4 months to observe the change of BMD and bone biomechanical parameters of the lumbar vertebrae

and the serum levels of total cholesterol (TC)

triglyceride(TG)

high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C)

and reduced the serum TC and LDL-C levels (P< 0.01). In the Nilestriol group

the wet weight of uterus got increased obviously (P< 0.01)

the number of uterine glands increased

uterine columnar epithelium thickened

reduce the serum TC and LDL-C levels

yet produce no adverse reaction in stimulating proliferation and hypertrophy of uterus.

关键词

Gengnianchun Recipepostmenopausal osteoporosisBone Mineral Densitybone biomechanicsTotal Cholesterollow-density lipoprotein cholesterol

Keywords

Gengnianchun Recipepostmenopausal osteoporosisBone Mineral Densitybone biomechanicsTotal Cholesterollow-density lipoprotein cholesterol

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