Effects of Yizhi Capsule on learning and memory disorder and β-amyloid peptide induced neurotoxicity in rats

Wu Hang-yu; Xu Jiang-ping; Li Lin; Zhu Bai-hua

doi:10.1007/BF02857361

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Effects of Yizhi Capsule on learning and memory disorder and β-amyloid peptide induced neurotoxicity in rats

Updated：2021-08-27

- Effects of Yizhi Capsule on learning and memory disorder and β-amyloid peptide induced neurotoxicity in rats
- Chinese Journal of Integrative Medicine Vol. 12, Issue 2, Pages: 137-141(2006)
- Affiliations：
  
  1. Department of Pharmacology, First Military Medical University,Guangzhou
  2. Qixing Pharmaceutical Co. Ltd.,Guangzhou
- Author bio：
- Funds：
  
  Supported by the Social Development Research Program of Department of Science and Technology of Guangdong Province (No. 2KB04207S)
- DOI：10.1007/BF02857361
  CLC：
- Published：2006，
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Hang-yu, W., Jiang-ping, X., Lin, L. et al. Effects of Yizhi Capsule on learning and memory disorder and β-amyloid peptide induced neurotoxicity in rats., Chin. J. Integr. Med. 12, 137–141 (2006). https://doi.org/10.1007/BF02857361

Wu Hang-yu, Xu Jiang-ping, Li Lin, et al. Effects of Yizhi Capsule on learning and memory disorder and β-amyloid peptide induced neurotoxicity in rats. [J]. Chinese Journal of Integrative Medicine 12(2):137-141(2006)
Hang-yu, W., Jiang-ping, X., Lin, L. et al. Effects of Yizhi Capsule on learning and memory disorder and β-amyloid peptide induced neurotoxicity in rats., Chin. J. Integr. Med. 12, 137–141 (2006). https://doi.org/10.1007/BF02857361 DOI：

Wu Hang-yu, Xu Jiang-ping, Li Lin, et al. Effects of Yizhi Capsule on learning and memory disorder and β-amyloid peptide induced neurotoxicity in rats. [J]. Chinese Journal of Integrative Medicine 12(2):137-141(2006) DOI： 10.1007/BF02857361.

摘要

Objective: To explore the effects of Yizhi Capsule (YZC) on learning and memory disorder and β-amyloid peptide induced neurotoxicity in rats.Methods: Various doses of YZC were administered to Sprague-Dawley (SD) rats for 8 consecutive days

twice a day. On the 8th day of the experiment

scopolamine hydrobromide was intraperitoneally injected to every rat and Morris water maze test and shuttle dark avoidance test were carried out respectively to explore the changes of learning and memory capacities in the rats. Besides

after the cerebral cortical neurons of newborn SD rats aged within 3 days were culturedin vitro for 7 days

drug serum containing YZC was added to the cultured neurons before or after β amyloid peptide25–35 (Aβ25–35) intoxication to observe the protective effect of YZC on neurotoxicity by MTT assay and to determine the LDH content in the supernatant.Results: Compared with those untreated with YZC

the rats having received YZC treatment got superiority in shorter time of platform seeking in Morris water maze test

as well as elongated latent period and less times of error in shuttle dark avoidance test. On the cultured neurons

YZC drug serum could effectively increase the survival rate of Aβ25–35 intoxicated neurons and reduce the LDH contents in cultured supernatant.Conclusion: YZC has an action of improving learning and memory disorder

and good protective effect on Aβ25–35 induced neurotoxicity in SD rats.

Abstract

twice a day. On the 8th day of the experiment

after the cerebral cortical neurons of newborn SD rats aged within 3 days were culturedin vitro for 7 days

the rats having received YZC treatment got superiority in shorter time of platform seeking in Morris water maze test

as well as elongated latent period and less times of error in shuttle dark avoidance test. On the cultured neurons

and good protective effect on Aβ25–35 induced neurotoxicity in SD rats.

关键词

learning and memory disorderβ-amyloid peptideneurotoxicity

Keywords

learning and memory disorderβ-amyloid peptideneurotoxicity

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