Clinical observation on treatment of chronic aplastic anemia by Shengxuening and cyclosporin a

Zhang Xue-zhong; Xu Yan-li; Jin Juan; Zhang Xiu-qun; Zhang Lei; Su Ai-ling

doi:10.1007/BF02857362

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Clinical observation on treatment of chronic aplastic anemia by Shengxuening and cyclosporin a

Updated：2021-08-27

- Clinical observation on treatment of chronic aplastic anemia by Shengxuening and cyclosporin a
- Chinese Journal of Integrative Medicine Vol. 12, Issue 2, Pages: 142-145(2006)
- Affiliations：
  
  Depatment of Hematology, The First Hospital Affiliated to Nanjing Medical University,Nanjing
- Author bio：
- Funds：
- DOI：10.1007/BF02857362
  CLC：
- Published：2006，
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Xue-zhong, Z., Yan-li, X., Juan, J. et al. Clinical observation on treatment of chronic aplastic anemia by Shengxuening and cyclosporin a., Chin. J. Integr. Med. 12, 142–145 (2006). https://doi.org/10.1007/BF02857362

Zhang Xue-zhong, Xu Yan-li, Jin Juan, et al. Clinical observation on treatment of chronic aplastic anemia by Shengxuening and cyclosporin a. [J]. Chinese Journal of Integrative Medicine 12(2):142-145(2006)
Xue-zhong, Z., Yan-li, X., Juan, J. et al. Clinical observation on treatment of chronic aplastic anemia by Shengxuening and cyclosporin a., Chin. J. Integr. Med. 12, 142–145 (2006). https://doi.org/10.1007/BF02857362 DOI：

Zhang Xue-zhong, Xu Yan-li, Jin Juan, et al. Clinical observation on treatment of chronic aplastic anemia by Shengxuening and cyclosporin a. [J]. Chinese Journal of Integrative Medicine 12(2):142-145(2006) DOI： 10.1007/BF02857362.

摘要

Objective: To explore the therapy to further elevate the efficacy of the treatment of chronic aplastic anemia (CAA).Methods: Forty-five patients with CCA were assigned into two groups

the 26 patients in the treated group were treated by Shengxuening (a Chinese herbal preparation) and cyclosporin A (CsA)

and the 19 patients in the control group were treated with androgen alone

with the therapeutic course lasting for over 3 months. Changes of peripheral blood picture

and the colony productivity of burst forming unit-erythroid (BFU-E)

colony forming unit-erythroid (CFU-E) and colony forming unit-granulocyte macrophage (CFU-GM) in bone marrow were observed before and after 3 months treatment. The amount of erythrocyte and platelet infusion

frequency of infection

condition of hemorrhage and relevant death were also observed. The follow-up study was conducted for over half a year.Results: The total effective rate in the treated group was 84.6%

which was significantly higher than that in the control group (52.6 %

P< 0.05). Levels of hemoglobin

reticulocyte

neutrophil and platelet increased after treatment in the treated group

as compared with those before treatment

with significant difference (P< 0.05)

and the colony productivity of BFU-E

CFU-E and CFU-GM in bone marrow also got significantly increased (P< 0.01)

and showed significant difference from those in the control group (P< 0.05).Conclusion: Shengxuening-assisting CsA therapy is an effective measure for treatment of CAA.

Abstract

Objective: To explore the therapy to further elevate the efficacy of the treatment of chronic aplastic anemia (CAA).Methods: Forty-five patients with CCA were assigned into two groups

the 26 patients in the treated group were treated by Shengxuening (a Chinese herbal preparation) and cyclosporin A (CsA)

and the 19 patients in the control group were treated with androgen alone

with the therapeutic course lasting for over 3 months. Changes of peripheral blood picture

and the colony productivity of burst forming unit-erythroid (BFU-E)

frequency of infection

condition of hemorrhage and relevant death were also observed. The follow-up study was conducted for over half a year.Results: The total effective rate in the treated group was 84.6%

which was significantly higher than that in the control group (52.6 %

P< 0.05). Levels of hemoglobin

reticulocyte

neutrophil and platelet increased after treatment in the treated group

as compared with those before treatment

with significant difference (P< 0.05)

and the colony productivity of BFU-E

CFU-E and CFU-GM in bone marrow also got significantly increased (P< 0.01)

and showed significant difference from those in the control group (P< 0.05).Conclusion: Shengxuening-assisting CsA therapy is an effective measure for treatment of CAA.

关键词

Shengxueningcyclosporin Aaplastic anemia

Keywords

Shengxueningcyclosporin Aaplastic anemia

references

Liu XL, Chen K, Shi H, et al. Effect of sodium iron chlorophyllin (SIC) on CFU-E and CFU-GM yields of normal and anemic animal models. Chin J Hematol 1997; 18(5): 234–236.

Zhang ZN. Standard for diagnosis and therapeutic efficacy evaluation of hematopathy. 2 nd ed. Beijing: Science Press, 1998: 33–36.

Leonard EM, Raefsky E, Criffith P, et al. Cyclosporin therapy of aplastic anemia, congenital and acquired red cell aplasia. Br J Haematol 1989; 72: 278–279

Chen GB, Shao ZH, Jia HR, et al. In vitro proliferation and differentiation of bone marrow stem cells of aplastic anemia patients. Chin J Hematol 1999; 20(10): 529–531.

Ke YF, Wei KM, Zhen JX, et al. Study on treatment of iron-deficiency anemia by Shengxuening. Chin J Integr Tradit West Med 2004; 24(10): 893–896.

Zhao TF, Wang SQ, Wang XY, et al. Experimental study of sodium copper chlorophyllin in the treatment of aplastic anemia. Zhejiang Med J 1989; 11(3): 193–195.

Wei KM, Qiu WY, Cao BZ, et al. Clinical report of sodium copper chlorophyllin in treating chronic aplastic anemia. Bull Med Res 1991; 20(1): 24–25.

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Department of Hematology, the First Affi liated Hospital, Zhejiang University of Traditional Chinese Medicine

Department of Hematology, First Clinical Medical College Affiliated to Zhejiang University of Traditional Chinese Medicine

Hematology Disease Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences

Institute of Hematology, The First Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine

Clinical Teaching and Research Section of TCM, College of Integrative Chinese and Western Medicine, Hebei Medical University

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