Randomized double-blinded and controlled clinical trial on treatment of HIV/AIDS by Zhongyan-4

Wang Jian; Yang Feng-zhen; Zhao Min; Zhang Yun-hui; Zhang Yong-xiang; Liu Ying; Liu Wei-min; Wang Fu-sheng; Xu Shu-ling; Yu Zhi-min; Xie Yan-ming; Zhou Xian-zhi; Iang Tian-jun

doi:10.1007/BF02857422

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Randomized double-blinded and controlled clinical trial on treatment of HIV/AIDS by Zhongyan-4

Updated：2021-08-27

- Randomized double-blinded and controlled clinical trial on treatment of HIV/AIDS by Zhongyan-4
- Chinese Journal of Integrative Medicine Vol. 12, Issue 1, Pages: 6-11(2006)
- Affiliations：
  
  1. Department of AIDS, Institute of Basic Theory, China Academy of Chinese Medical Sciences,Beijing
  2. The Hospital of PLA,China,302
- Author bio：
- Funds：
  
  Supported by the Projects of Ministry of Science and Technology for 10th Five-year Plan (2001BA701A18)
- DOI：10.1007/BF02857422
  CLC：
- Published：2006，
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Jian, W., Feng-zhen, Y., Min, Z. et al. Randomized double-blinded and controlled clinical trial on treatment of HIV/AIDS by Zhongyan-4., Chin. J. Integr. Med. 12, 6–11 (2006). https://doi.org/10.1007/BF02857422

Wang Jian, Yang Feng-zhen, Zhao Min, et al. Randomized double-blinded and controlled clinical trial on treatment of HIV/AIDS by Zhongyan-4. [J]. Chinese Journal of Integrative Medicine 12(1):6-11(2006)
Jian, W., Feng-zhen, Y., Min, Z. et al. Randomized double-blinded and controlled clinical trial on treatment of HIV/AIDS by Zhongyan-4., Chin. J. Integr. Med. 12, 6–11 (2006). https://doi.org/10.1007/BF02857422 DOI：

Wang Jian, Yang Feng-zhen, Zhao Min, et al. Randomized double-blinded and controlled clinical trial on treatment of HIV/AIDS by Zhongyan-4. [J]. Chinese Journal of Integrative Medicine 12(1):6-11(2006) DOI： 10.1007/BF02857422.

摘要

Objective: To assess the efficacy and safety of Zhongyan-4 (ZY-4

a Chinese herbal preparation worked out according to the therapeutic principle of supplementing qi

nourishing Yin

clearing heat and detoxication) in treating HIV/AIDS patients in the early or middle stage.Methods: Adopted was randomized double-blinded and placebo-parallel-controlled method

with 72 HIV/AIDS patients randomly divided into the ZY-4 group (36 patients) treated with ZY-4 and the control group (36 patients) treated with placebo. The treatment course was six months. The index of CD 4 +

CD 8 + counts

body weight

clinical symptom scoring were estimated at 4 time points (0

3 and 6 month in the course)

and also the viral load before and after treatment. The whole course of observation was completed in 63 patients

30 in the ZY-4 group and 33 in the control group.Results: CD 4 + count in the ZY-4 group got elevated by 7.70 ± 150.96/mm3 on average

while that in the control group lowered by 27.33 ± 85.28 /mm3. Fifteen out of the 30 patients in the ZY-4 group had their CD 4 + count increased

which was evidently much higher than that in the control group (8/33

P<0.05)

suggesting that the efficacy of ZY-4 is superior to that of placebo in elevating CD 4 + count. Moreover

ZY-4 showed actions in elevating CD45RA+ and CD 8 + count

reducing HIV virus load

improving clinical symptom/sign and increasing body weight of patients. No obvious adverse reaction was found in the clinical trial.Conclusion: ZY-4 has an immunity-protective and/or rebuilding function in HIV/AIDS patients in the early and middle stage

and also shows effects in lowering viral load

increasing body weight and improving symptoms and signs to a certain degree.

Abstract

Objective: To assess the efficacy and safety of Zhongyan-4 (ZY-4

a Chinese herbal preparation worked out according to the therapeutic principle of supplementing qi

nourishing Yin

clearing heat and detoxication) in treating HIV/AIDS patients in the early or middle stage.Methods: Adopted was randomized double-blinded and placebo-parallel-controlled method

CD 8 + counts

body weight

clinical symptom scoring were estimated at 4 time points (0

3 and 6 month in the course)

and also the viral load before and after treatment. The whole course of observation was completed in 63 patients

30 in the ZY-4 group and 33 in the control group.Results: CD 4 + count in the ZY-4 group got elevated by 7.70 ± 150.96/mm3 on average

while that in the control group lowered by 27.33 ± 85.28 /mm3. Fifteen out of the 30 patients in the ZY-4 group had their CD 4 + count increased

which was evidently much higher than that in the control group (8/33

P<0.05)

suggesting that the efficacy of ZY-4 is superior to that of placebo in elevating CD 4 + count. Moreover

ZY-4 showed actions in elevating CD45RA+ and CD 8 + count

reducing HIV virus load

and also shows effects in lowering viral load

increasing body weight and improving symptoms and signs to a certain degree.

关键词

HIV/AIDSprinciple for supplementing Qinourishing Yinclearing heat and detoxicationZhongyan-4T-Iymphocyte subsetsHIV viral load

Keywords

HIV/AIDSprinciple for supplementing Qinourishing Yinclearing heat and detoxicationZhongyan-4T-Iymphocyte subsetsHIV viral load

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The First Affiliated Hospital of Medical College of Zhejiang University

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