Clinical study of Jiawei Huangqi Guizhi Wuwu Decoction in preventing and treating peripheral neuro-sensory toxicity caused by oxaliplatin

Li Yuan; Gui Hui-juan; Huang Jin-chang; Wu Xiao-qin

doi:10.1007/BF02857424

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Clinical study of Jiawei Huangqi Guizhi Wuwu Decoction in preventing and treating peripheral neuro-sensory toxicity caused by oxaliplatin

Updated：2021-08-27

- Clinical study of Jiawei Huangqi Guizhi Wuwu Decoction in preventing and treating peripheral neuro-sensory toxicity caused by oxaliplatin
- Chinese Journal of Integrative Medicine Vol. 12, Issue 1, Pages: 19-23(2006)
- Affiliations：
  
  Department of Oncology, China-Japan Friendship Hospital,Beijing
- Author bio：
- Funds：
- DOI：10.1007/BF02857424
  CLC：
- Published：2006，
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Yuan, L., Hui-juan, G., Jin-chang, H. et al. Clinical study of Jiawei Huangqi Guizhi Wuwu Decoction in preventing and treating peripheral neuro-sensory toxicity caused by oxaliplatin., Chin. J. Integr. Med. 12, 19–23 (2006). https://doi.org/10.1007/BF02857424

Li Yuan, Gui Hui-juan, Huang Jin-chang, et al. Clinical study of Jiawei Huangqi Guizhi Wuwu Decoction in preventing and treating peripheral neuro-sensory toxicity caused by oxaliplatin. [J]. Chinese Journal of Integrative Medicine 12(1):19-23(2006)
Yuan, L., Hui-juan, G., Jin-chang, H. et al. Clinical study of Jiawei Huangqi Guizhi Wuwu Decoction in preventing and treating peripheral neuro-sensory toxicity caused by oxaliplatin., Chin. J. Integr. Med. 12, 19–23 (2006). https://doi.org/10.1007/BF02857424 DOI：

Li Yuan, Gui Hui-juan, Huang Jin-chang, et al. Clinical study of Jiawei Huangqi Guizhi Wuwu Decoction in preventing and treating peripheral neuro-sensory toxicity caused by oxaliplatin. [J]. Chinese Journal of Integrative Medicine 12(1):19-23(2006) DOI： 10.1007/BF02857424.

摘要

Objective: To evaluate the efficacy of Jiawei Huangqi Guizhi Wuwu Decoction (JHGWD) in treating neuro-sensory toxicity induced by oxaliplatin.Methods: A randomized controlled self-crossover trial was performed. Thirty-one patients were randomly divided into AB and BA groups. Patients in A cycle belonged to the treated group

who were treated with chemotherapy combined with oxaliplatin plus JHGWD. Patients in B cycle belonged to the control group and were treated with chemotherapy alone. The peripheral neuro-sensory toxicity was observed and analyzed.Results: The main neurotoxicity was cold-induced paresthesia after the use of oxaliplatin

which included hyperaesthesia

chill

anaesthesia in the extremities

electrified sensation

formication

foreign body sensation and pain that might be exacerbated by exposure to cold. Twenty patients (64.5%) suffered from neuro-sensory toxicity in the treated group and 27 cases (87. 1%) in the control group. Symptoms were more serious and lasted longer in the control group than those in the treated group (P<0.01).Conclusion: JHGWD could prevent and reduce the occurence and intensity of acute peripheral neuro-sensory toxicity caused by oxaliplatin.

Abstract

which included hyperaesthesia

chill

anaesthesia in the extremities

electrified sensation

formication

关键词

oxaliplatinneurological toxicityJiawei Huangqi Guizhi Wuwu Decoctionprevention and treatment

Keywords

oxaliplatinneurological toxicityJiawei Huangqi Guizhi Wuwu Decoctionprevention and treatment

references

Feng B, Yu JM, Guo QS, et al. Observation of affection on advanced stomach cancer of oxaliplatin. Chin J Cancer Prev Treat 2004; 11(3): 301–303.

Betheault-Cvitkovic F, Jami A, Ithzaki M, et al. Biweekly intensified ambulatory chronomodulated chemotherapy with oxaliplatin, fluorouracil, and leuovorin in patients with metastatic colorectal cancer. J Clin Oncol 1996; 14: 2950–2958.

Wang MP, Ma LW, Zhang SL, et al. Clinical study of peripheral neuro-sensory toxicity caused by the regimen combined with oxaliplatin treating colorectal cancer. Chin J Cancer Prev Treat 2004; 11(2): 168–170.

Su QG, Che CY. Clinical study of oxaliplatin. Foreign Med Sci: Oncol Sect 1999; 26(4): 208–210.

Raymond E, Chaney SG, Taama A, et al. Oxaliplatin: a review of preclinical and clinical studies. Ann Oncol 1998; 9(10): 1053–1071.

Hu GQ, Fu Q, Jin ML, et al. Clinical study of oxaliplatin combined with hydroxycamptothecin, flurouracil, folinic acid treating 36 advanced gastric cancer. Chin J Clin Oncol 2004; 31(9): 506–512.

Armand JP, Su Y, Guan ZZ, et al. Oxaliplatin in the treatment of advanced colorectal cancer—a review of clinical studies. Cancer 1999; 18(6): 624–630.

Cersosimo RJ. Oxaliplatin-associated neuropathy: a review. Ann Pharmacother 2005; 39(1): 128–135.

Screnci D, Er HM, Hambleg TW. Stereoselective peripheral sensory neurotoxicity of diaminocy clohexane platinum enantiomes related to ormaplatin and oxaliplatin. Br JCancer1997; 76(4): 502–510.

Grolleau F, Gamelin L, Boisdron-Celle M, et al. A possible explanation for a neurotoxic effect of the anticancer agent oxaliplatin on neuronal voltage-gated sodium channels. J Neurophysiol 2001; 85(5): 2293–2297.

McKeage MJ, Hsu T, Screnci D, et al. Nucleolar damage correlates with neurotoxicity induced by different platinum drugs. Br J Cancer 2001; 85(8): 1219–1225.

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