Protective effect of Ginkgo biloba leaf extract on learning and memory deficit induced by aluminum in model rats

Gong Qi-hai; Wu Qin; Huang Xie-nan; Sun An-sheng; Nie Jing; Shi Jing-shan

doi:10.1007/BF02857428

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Protective effect of Ginkgo biloba leaf extract on learning and memory deficit induced by aluminum in model rats

Updated：2021-08-27

- Protective effect of Ginkgo biloba leaf extract on learning and memory deficit induced by aluminum in model rats
- Chinese Journal of Integrative Medicine Vol. 12, Issue 1, Pages: 37-41(2006)
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- Funds：
  
  Supported by the Project of Governor Talent Foundation of Guizhou Province (No. 2001016)
- DOI：10.1007/BF02857428
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- Published：2006，
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Qi-hai, G., Qin, W., Xie-nan, H. et al. Protective effect of Ginkgo biloba leaf extract on learning and memory deficit induced by aluminum in model rats., Chin. J. Integr. Med. 12, 37–41 (2006). https://doi.org/10.1007/BF02857428

Gong Qi-hai, Wu Qin, Huang Xie-nan, et al. Protective effect of Ginkgo biloba leaf extract on learning and memory deficit induced by aluminum in model rats. [J]. Chinese Journal of Integrative Medicine 12(1):37-41(2006)
Qi-hai, G., Qin, W., Xie-nan, H. et al. Protective effect of Ginkgo biloba leaf extract on learning and memory deficit induced by aluminum in model rats., Chin. J. Integr. Med. 12, 37–41 (2006). https://doi.org/10.1007/BF02857428 DOI：

Gong Qi-hai, Wu Qin, Huang Xie-nan, et al. Protective effect of Ginkgo biloba leaf extract on learning and memory deficit induced by aluminum in model rats. [J]. Chinese Journal of Integrative Medicine 12(1):37-41(2006) DOI： 10.1007/BF02857428.

摘要

Objective: To examine the protective effect of Ginkgo biloba leaf extract (GbE) on learning and memory deficit induced by aluminum chloride (AlCl3)

and explore its mechanisms.Methods: The rat models with learning and memory deficit were induced by administering via gastrogavage and drinking of AlCl3 solution. And the model rats were treated with GbE at the dose of 50

100

200 mg/kg every day for 2 months accompanied with drinking of AlCl3 solution

respectively. Their abilities of spatial learning and memory were tested by Morris water maze

and the acetylcholinesterase (AChE) activity in serum was assayed with chemical method

the AChE expression in hippocampus was observed by immunohistochemistry assay

and then quantitative analysis was done by Bl 2000 image analysis system.Results: Learning and memory deficit of rats could be induced by AlCl3 solution (P<0.01)

and AChE expressions in rats hippocampus were increased (P<0.01); GbE ameliorated learning and memory deficit and reduced AChE expression in rats hippocampus in a dose-dependent manner

while GbE significantly increased serum AChE activity at the dose of 200 mg/kg each day (P<0.05).Conclusion: GbE can ameliorate learning and memory deficit induced by AlCl3

which may be due to its inhibition of the AChE expression in hippocampus.

Abstract