FOLLOWUS
Current status of clinical and experimental researches on cognitive impairment in diabetes
- Chinese Journal of Integrative Medicine Vol. 12, Issue 1, Pages: 68-74(2006)
- Affiliations：
1. Peking Union Medical College Hospital, Chinese Academy of Medical Science,Beijing
2. Laboratory of Kampo medicine, Department of Cellular and Structural biology, The Texas Health Science Center at San Antonio,USA
- Author bio：
- Funds：
DOI：10.1007/BF02857437
CLC：Published：2006，
Scan for full text
Xiao-chun, L., Sai-shan, G. & Hagino, N. Current status of clinical and experimental researches on cognitive impairment in diabetes., Chin. J. Integr. Med. 12, 68–74 (2006). https://doi.org/10.1007/BF02857437
Liang Xiao-chun, Guo Sai-shan, Nobuyoshi Hagino. Current status of clinical and experimental researches on cognitive impairment in diabetes. [J]. Chinese Journal of Integrative Medicine 12(1):68-74(2006)
Xiao-chun, L., Sai-shan, G. & Hagino, N. Current status of clinical and experimental researches on cognitive impairment in diabetes., Chin. J. Integr. Med. 12, 68–74 (2006). https://doi.org/10.1007/BF02857437 DOI：
Liang Xiao-chun, Guo Sai-shan, Nobuyoshi Hagino. Current status of clinical and experimental researches on cognitive impairment in diabetes. [J]. Chinese Journal of Integrative Medicine 12(1):68-74(2006) DOI： 10.1007/BF02857437.
摘要
This article reviews the clinical and experimental researches on cognitive impairment related to diabetes in the recent decade. Most clinical studies indicate that the cognitive impairment in patients with type 1 diabetes mellitus is related to recurrent hypoglycemia closely. There is little research about whether or not hyperglycemia is related to cognitive impairment in patients with type 1 diabetes mellitus. Most studies indicate that the cognitive impairment in type 2 diabetes involves multiple factors through multiple mechanisms
including blood glucose
blood lipid
blood pressure
level of insulin
medication
chronic complication
etc. But
there has been no large-scale
multi-center
randomized controlled clinical trial in China recently. And what is more
some problems exist in this field of research
such as the lack of golden criterion of cognitive function measurement
different population of studied objects
and incomprehensive handling of confounding factors. Experimental studies found that hippocampal long-term potentiation (LTP) was impaired
which were manifested by impairment of spatial memory and decreased expression of LTP
but its relation to hyperglycemia
the duration of diabetes
learning and memory has always been differently reported by different researches. Thus
there are a lot of unknown things to be explored and studied in order to clarify its mechanism. TCM has abundant clinical experience in treating cerebral disease with medicine that enforces the kidney and promotes wit. However
there has been no research on treating diabetic cognitive impairment
which requires work to be done actively and TCM to be put into full play
in order to improve the treatment of diabetes and enhance living quality of patients.
Abstract
This article reviews the clinical and experimental researches on cognitive impairment related to diabetes in the recent decade. Most clinical studies indicate that the cognitive impairment in patients with type 1 diabetes mellitus is related to recurrent hypoglycemia closely. There is little research about whether or not hyperglycemia is related to cognitive impairment in patients with type 1 diabetes mellitus. Most studies indicate that the cognitive impairment in type 2 diabetes involves multiple factors through multiple mechanisms
including blood glucose
blood lipid
blood pressure
level of insulin
medication
chronic complication
etc. But
there has been no large-scale
multi-center
randomized controlled clinical trial in China recently. And what is more
some problems exist in this field of research
such as the lack of golden criterion of cognitive function measurement
different population of studied objects
and incomprehensive handling of confounding factors. Experimental studies found that hippocampal long-term potentiation (LTP) was impaired
which were manifested by impairment of spatial memory and decreased expression of LTP
but its relation to hyperglycemia
the duration of diabetes
learning and memory has always been differently reported by different researches. Thus
there are a lot of unknown things to be explored and studied in order to clarify its mechanism. TCM has abundant clinical experience in treating cerebral disease with medicine that enforces the kidney and promotes wit. However
there has been no research on treating diabetic cognitive impairment
which requires work to be done actively and TCM to be put into full play
in order to improve the treatment of diabetes and enhance living quality of patients.
关键词
diabetesimpairment of cognitivememory and learning
Keywords
diabetesimpairment of cognitivememory and learning
references
Rovet JF, Ehrlicb RM. The effect of hypoglycemic seizures on cognitive function in children with diabetes: a 7-year prospective study. J Pediatri 1999; 134 (4): 503–506.
Hershey T, Bhargava N, Sadler M, et al. Conventional versus intensive diabetes therapy in children with type 1 diabetes: effects on memory and motor speed. Diabetes Care 1999; 22 (8): 1318–1324.
Bjorgaas M, Gimse R, Vik T, et al. Cognitive function in type 1 diabetes children with and without episodes of severe hypoglycaemia. Acta Paediatr 1997; (86): 148–153.
Ferguson SC, Blane A, Wardlaw J, et al. Influence of an early-on-set age of type 1 diabetes on cerebral structure and cognitive function. Diabetes Care 2005; 28(6): 1431–1437.
Lincoln NB, Kirk BA, Faleiro RM, et al. Effect of long-term glycemic control on cognitive function. Diabetes Care 1996; 19(6): 656–658.
Ryan CM, Williams TM, Finegold DN, et al. Cognitive dysfunction in adults with type 1 (insulin-dependent) diabetes mellitus of long duration: effects of recurrent hypoglycaemia and orther chronic complications. Diabetologia 1993; 36(4): 329–334.
Reichard P, Berglund A, Britz S, et al. Hypoglycemie episodes during intensified insulin treatment: increased frequency but no effect on cognitive function. J Intern Med1991; 229 (1): 9–16.
Reichard P, Britz A, Rosenqvist U. Intensified conventional insulin treatment and neuropsychological impairment. BMJ 1991; 303 (6815): 1439–1442.
Kramer L, Fasching P, Madl C. et al. Previous episodes of hypoglycemic coma are not associated with permanent cognitive brain dysfunction in IDDM patients on intensive insulin treatment. Diabetes 1998; 47 (12): 1909–1914.
Austin EJ, Deary DU. Effect of repeated hypoglycemia on cognitive function: a psychometrically validated reanalysis of the diabetes control and complications trial data. Diabetes Care 1999; 22 (8): 1273–1277.
Gregg EW, Yaffe K, Cauley JA, et al. Is diabetes associated with cognitive impairment and cognitive decline among older women? Study of Osteoporotic Fractures Research Group. Arch Intern Med 2000; 160(2): 174–180.
Crooks VC, Buckwalter JG, Petitti DB. Diabetes mellitus and congnitive performance in older women. Ann Epidemiol 2003; 13 (9): 613–619.
Yaffe K, Blackwell T, Kanaya AM, et al. Diabets impaired fasting glucose, and development of cognitive impairment in older women. Neurology 2004; 63(4): 658–663.
Kalmijin S, Feskens EJ, Launer LJ, et al. Glucose intolerance, hyperinsulinaemia and cognitive function in a general population of elderly men. Diabetologia 1995; 38 (9): 1096–1102.
Logroscino G. Kang JH, Grodstein F. Prospective study of type 2 diabetes and cognitive decline in women aged 70–81 years. BMJ 2004; 328(7439): 548.
Dey J, Misra A, Desai NG, et al. Cognitive function in younger type II diabetes. Diabetes Care 1997; 20 (1): 32–35.
ZhaoY, Liu FY. A Preliminary investigation of cognitive dysfunctionin type 2 Diabetes. Chin Mental Health J2000; 14 (1): 21–24.
Kadoi Y, Saito S, Fujita N, et al. Risk factors for cognitive dysfunction after coronary artery bypass graft surgery in patients with type 2 diabetes. J Thorac Cardiovasc Surg 2005; 129 (3): 576–583.
Sommerfield AJ, Deary IJ, Frier BM. Acute hyperglycemia alters mood state and impairs cognitive performance in people with type 2 diabetes. Diabetes Care 2004; 27(10): 2335–2340.
Messier C, Tsiakas M, Gagnon M, et al. Effect of age and glucoregulation on cognitive performance. Neurobiol Aging 2003; 24 (7): 985–1003.
Mogi N, Umegaki H, Hattori A, et al. Congnitive function in Japannese elderly with type 2 diabetes mellitus. J Diabetes Complications 2004; 18 (1): 42–46.
Wang YG, Wang W, Yu HW, et al. A clinical study on memory disorders in NIDDM. Chin J Diabetes 1995; 3(4): 219–221.
Zuo LJ, Ji JL, Xu JM, et al. A pilot study of cognitive function and related factors among the patients with type 2 diabets. Chin J Behavioral Med Sci 2001; 10(2): 95–97.
Elias PK, Eliass MF, D’Agostino RB, et al. NIDDM and blood pressure as risk factors for poor cognitive performance. Diabetes Care 1997; 20: 1388–1395.
Vanhanen M, Kuusisto J, Koivisto K, et al. Type-2 diabetes and cognitive function in a non-demented population. Acta Neurol Scand 1999; 100(2): 97–101.
Muqit MM, Ferdous HS. Cognitive impairment in elderly, non-insulin-dependent diabetic men in Bangladesh. Bangladesh Med Res Counc Bull 1998; 24(2): 23–26.
Biessels GJ, Kamal A, Ramakers GM, et al. Place learning and hippocampal synaptic plasticity in streptozotocin-induced diabetic rats. Diabetes 1996; 45(9): 1259–1266.
Kamal A, Biessels GJ, Urban IJA, et al. Hippocampal synaptic plasticity in streptozotocin-induced diabetic rats: impairment of long-term potentiation and facilitation of long-term depression. Neuroscience 1999; 90(3): 737–745.
Chabot C, Massicotte G, Milot M, et al. Impaired modulation of AMPA receptors by calcium-dependent processes in streptozotocininduced diabetic rats. Brain Res 1997; 768(1-2): 249–256.
Gagne J, Milot M, Gelinas S, et al. Binding properties of glutamate receptors in streptozotocin-induced diabetic rats. Diabetes 1997; 46 (5): 841–846.
DiLucaM, Ruts L, Gardoni F, et al. NMDA receptor subunits are modified transcriptionally and post-translationally in the brain of streptozotocin-diabetic rats. Diabetologia 1999; 42(6): 693–701.
Dalibas N, Kilinc I, Yonden Z, et al. NMDA receptor subunits 2A and 2B decrease and lipid peroxidation increase in the hippocampus of streptozotocin diabetic rats: effect of insulin and gliclazide treatments. Int J Neurosci 2004; 114(3): 391–401.
Liu G, Chen L. Rang XK, et al. Expression of nitric oxide sythase in hippocampus of streptozotocin-induced diabetic rats and relation between nitric oxidre and cognitive function. J Shandong Univ Health Sci 2003; 41(2): 171–174.
Ma XY, Sheng SL, Hu JS, et al. A study on the association of cognitive with cerebral morphological change in streptozotocin-diabetic rats. Chin J Diabetes 1999; 7(3): 150–153.
Zhang SY, Zhang QJ, Shao SX, et al. The ultrastrucre study of the hippocampus in diabetic rats and effect of insulin. Progress Anat Sci 2001; 7 (4): 303–305.
Zhao YM, Zhao ZW, Qian YY, et al. The effect of memory enhancing peptied on hippocampal neuron morphology and choline acetyltranserase espression in diabetic mice. Chin J Diabetes 1999; 7(6): 347–349.
Zhao YM, Ji ZJ, Zhao ZW, et al. On the mechanism of Tau protein hyperphosphorylation in brain tissues of diabetic mice. Chin J Endocr Metab 1999; 15(1): 38–40.
Mooradian AD. Central nervous complications of diabetes mellitus a perspective from the the blood-brain barrier. Neurosci 1997; 23: 210–214.
Zhang SY, Zhang ZS, Su SG, et al. Preventive effect of insulin in rat model with DM of the hippocampus. Chin J Endocr Metab 2001; 17(2): 121–122.
Lupien SB, Bluhm EJ, Ishii DN. Systemic insulin-like growth factor-1 administration prevents cognitive impairment in diabetic rats, and brain IGF regulates learning/memory in normal adult rats. J Neurosci Res. 2003; 74(4): 512–523.
Sima AA, Li ZG. The effect of C-peptide on cognitive dysfunction and hippocampal apoptosis in type 1 diabetic rats. Diabetes 2005; 54(5): 1497–1505.
Delibas N, Altuntas I, Sutcu R, et al. Effect of dietary long chain PUFAs on hippocampal lipid peroxidation and NMDA receptor subunits A and B concentration in streptozotocin-diabetic rats. Int J Neurosci 2004; 114(10): 1353–1364.
Li HX, Wang R, Du YF, et al. Effect of APP-17 peptide on modulation neuronal mitochondria trans membrane potentials in hippocampaus of STZ-DM rats. J Capital Univ Med Sci 2003; 24(1): 40–43.
Qian YY, Zhao YM, Ji ZJ, et al. The effect of APP-17 peptide on the function of learning and memory and NT-3, choline acetyltranserase neuron of hippocampus in diabetic mice. Chin J Geriatr 1999; 18(6): 349–352.
Sheng SL, Hu LX, Zhao YM, et al. Re-examination of pathogenesis of diabetic encephalopathy and effects of APP-17 peptide. Acta Anatomica Sinica 2001; 32(3): 12–215.
Qian YY, Zhao YM, Zhao ZW, et al. The effect of memory enhancing peptide on the function of learning and memory and NT-3 neuron in hippocampus of diabetic mice. Chin J Diabetes 1999; 7 (2): 94–97.
Tian GQ, Guo SS, Lu HQ, et al. Effect of Bushen Huoxue Recipe on learning and memory dysfunction and hippooampal nerve cell apoptosis in mice with cerebral ischemia reperfusion injury. Chinese J IntegrTradit West Med2003; 23(2): 123–127.
Zhao ZW, Wang PW, Song LN, et al. Protection of liquid extract of Jiunaoyizhi capsule against impairment of hippocampal neurons of dgalactose-induced aging mice. J Capital Univ Med Sci 2003; 24 (1): 32–36.
Lai SL, Hu JQ, Wang Q, et al. Preventive efeect of Bushen Yizhi Decoction on learning and memory in rat model with Alzheimer’s disease. J Guangzhou Univ Tradit Chin Med 2000; 17(2): 106–108.
Rao Y, Lai SL, Hu JQ, et al. Efeect of Bushen Yizhi Decoction on hippocampal long-term potentiation in rat model with Alzheimer’s disease. J Guangzhou Univ Tradit Chin Med 2000; 17(2): 109–112.
Li B, Li L, Zhang L, et al. Effect of Bushen Jiaonan 1 decoction on learning and memory functions and anti-fatigue ability in mice. China J Chin Material Medica 1999; 24(2): 104–106.
Qiao HF, Yang S, Zhou WX, et al. Inhibitory effect of active fraction of Tiaoxin recipe on β-amyloid protein induced long-term potentiation in CA1 area of rats hippocampal slices. Chin J Integr Tradit West Med 2005; 25(5): 429–431.
Draelos MT, Jacobson AM, Weinger K, et al. Cognitive function in patient with insulin-dependent diabetes mellitus during hyperglycemia and hypoglycemia. Am J Med 1995; 98(2): 135–144.
0
Views
362
Downloads
4
CSCD
- Meta-XMLDownload
- BibTeXDownload
- EndnoteDownload
- RefMan Download
- NoteExpressDownload
- NoteFirstDownload
Publicity Resources
Related Articles
Related Author
Related Institution
- Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
- Tel：010-62886827, 62877592 Fax：010-62874291
- Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1
京公网安备11010802024621 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
