Effect of fuzheng kangbai granule on immune function and survival time in minimal residual leukemia model mice

Yong-Gang Xu; Rou Ma; Nai-ping Hu; Feng Liu; Jing-min Yang; Ling Ma; Xiao-mei Hu

doi:10.1007/BF02934372

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Effect of fuzheng kangbai granule on immune function and survival time in minimal residual leukemia model mice

Updated：2021-08-27

- Effect of fuzheng kangbai granule on immune function and survival time in minimal residual leukemia model mice
- Chinese Journal of Integrative Medicine Vol. 7, Issue 4, Pages: 283-287(2001)
- Affiliations：
  
  Xiyuan Hospital, China Academy of TCM,Beijing
- Author bio：
- Funds：
  
  This study was supported by State Administration of TCM (No. 922153);and won the 3rd grade Award of 1998’ Scientific and Technological Advancement of China Academy of TCM
- DOI：10.1007/BF02934372
  CLC：
- Published：2001，
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Xu, Yg., Ma, R., Hu, Np. et al. Effect of fuzheng kangbai granule on immune function and survival time in minimal residual leukemia model mice., CJIM 7, 283–287 (2001). https://doi.org/10.1007/BF02934372

Yong-Gang Xu, Rou Ma, Nai-ping Hu, et al. Effect of fuzheng kangbai granule on immune function and survival time in minimal residual leukemia model mice. [J]. Chinese Journal of Integrative Medicine 7(4):283-287(2001)
Xu, Yg., Ma, R., Hu, Np. et al. Effect of fuzheng kangbai granule on immune function and survival time in minimal residual leukemia model mice., CJIM 7, 283–287 (2001). https://doi.org/10.1007/BF02934372 DOI：

Yong-Gang Xu, Rou Ma, Nai-ping Hu, et al. Effect of fuzheng kangbai granule on immune function and survival time in minimal residual leukemia model mice. [J]. Chinese Journal of Integrative Medicine 7(4):283-287(2001) DOI： 10.1007/BF02934372.

摘要

To observe the effects of Fuzheng Kangbai Granule (FZKBG) on immune function and survival time in minimal residual leukemia (MRL) model mice and explore its mechanism. MRL model mice were established by hypodermic inoculation with L7212 cells 1×106 following intraperitoneal injection of cytoxan (CTX) 250 mg/kg 3 days later

and divided into the control group and FZKBG treated group. The changes of T-lymphocyte subsets

including CD3 +

CD4 + and CD8 +

and the survival time in model mice were observed. Compared with the control

FZKBG could obviously increase both the percentage and absolute value of CD3 + and CD4 + lymphocytes and prolong the survival time of model mice

the prolongation rate being 29. 6% – 60. 4%. FZKBG could markedly prolong the survival time of MRL mice

and its mechanism might be through elevating the immunologic function and inhibiting the leukemia cells in model mice.

Abstract

and divided into the control group and FZKBG treated group. The changes of T-lymphocyte subsets

including CD3 +

CD4 + and CD8 +

and the survival time in model mice were observed. Compared with the control

FZKBG could obviously increase both the percentage and absolute value of CD3 + and CD4 + lymphocytes and prolong the survival time of model mice

the prolongation rate being 29. 6% – 60. 4%. FZKBG could markedly prolong the survival time of MRL mice

and its mechanism might be through elevating the immunologic function and inhibiting the leukemia cells in model mice.

关键词

Fuzheng Kangbai Granuleminimal residual leukemiaimmune function

Keywords

Fuzheng Kangbai Granuleminimal residual leukemiaimmune function

references

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Teng Y. Effect of Chinese herbs on transplanting lymphocyte leukemia in mice. Shanghai J TCM 1992; (3) :47–48.

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Gale RP, Bulturini T. Is transplantation in first remission AML more effective than in advanced leukemia? Leukemia Res 1989; 13(12): 1035–1039.

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