Experimental study on effect of bushen huoxue xiezhuo decoction in treating minute lesion nephropathy

Yue Zhang; Min Wei; Qian Wang; Fei Chu; Jing Yan; Bo-guang Li; Xu Jia

doi:10.1007/BF02934382

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Experimental study on effect of bushen huoxue xiezhuo decoction in treating minute lesion nephropathy

Updated：2021-08-27

- Experimental study on effect of bushen huoxue xiezhuo decoction in treating minute lesion nephropathy
- Chinese Journal of Integrative Medicine Vol. 7, Issue 4, Pages: 305(2001)
- Affiliations：
  
  Department of Pathology, Beijing University of TCM,Beijing
- Author bio：
- Funds：
- DOI：10.1007/BF02934382
  CLC：
- Published：2001，
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Zhang, Y., Wei, M., Wang, Q. et al. Experimental study on effect of bushen huoxue xiezhuo decoction in treating minute lesion nephropathy., CJIM 7, 305 (2001). https://doi.org/10.1007/BF02934382

Yue Zhang, Min Wei, Qian Wang, et al. Experimental study on effect of bushen huoxue xiezhuo decoction in treating minute lesion nephropathy. [J]. Chinese Journal of Integrative Medicine 7(4):305(2001)
Zhang, Y., Wei, M., Wang, Q. et al. Experimental study on effect of bushen huoxue xiezhuo decoction in treating minute lesion nephropathy., CJIM 7, 305 (2001). https://doi.org/10.1007/BF02934382 DOI：

Yue Zhang, Min Wei, Qian Wang, et al. Experimental study on effect of bushen huoxue xiezhuo decoction in treating minute lesion nephropathy. [J]. Chinese Journal of Integrative Medicine 7(4):305(2001) DOI： 10.1007/BF02934382.

摘要

To explore the therapeutic effect and mechanism of Bushen Huoxue Xiezhuo Decoction (BHXD) in treating minute lesion nephropathy (MLN) in rats. The MLN model rats established by a single intravenous injection of Adriamycin were divided into the model and the BHXD groups

and a normal group was set up for control. The effects of treatment on renal function

hemorrheologic parameters

renal tissue transforming growth factor β1 (TGF-β1 ) expression and poly-anion sites on glomerular basement membrane were observed dynamically. After treatment

all the parameters between the BHXD group and the model group were significantly different respectively

morphological observation also showed the pathological changes in the BHXD group were milder than those in the model group. BHXD treatment could markedly improve the renal function

alleviate blood hypercoagulability and hyperviscosity

protect the anion barrier and delay the progression of glomerular fibrosis and sclerosis.

Abstract

and a normal group was set up for control. The effects of treatment on renal function

hemorrheologic parameters

renal tissue transforming growth factor β1 (TGF-β1 ) expression and poly-anion sites on glomerular basement membrane were observed dynamically. After treatment

all the parameters between the BHXD group and the model group were significantly different respectively

morphological observation also showed the pathological changes in the BHXD group were milder than those in the model group. BHXD treatment could markedly improve the renal function

alleviate blood hypercoagulability and hyperviscosity

protect the anion barrier and delay the progression of glomerular fibrosis and sclerosis.

关键词

Experimental StudyRenal FunctionTherapeutic EffectPathological ChangeNormal Group

Keywords

Experimental StudyRenal FunctionTherapeutic EffectPathological ChangeNormal Group

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Children’s Hospital Shanghai Medical University

Department of Traditional Chinese Medicine, Medical College, Jinan University

Guangdong Province Integrative Medicine Hospital

Shandong Academy of Chinese Medicine

Department of Acu-moxibustion, Qilu Hospital of Shandong University

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