Effect of Chishao Chengqi decoction on endotoxin and TNF-α in patients with severe hepatic diseases

Qi-Kai Wu; Da-Guo Yang; Yan-Yan Tao; Guang Nie; Xin Deng

doi:10.1007/BF02934403

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Effect of Chishao Chengqi decoction on endotoxin and TNF-α in patients with severe hepatic diseases

Updated：2021-08-27

- Effect of Chishao Chengqi decoction on endotoxin and TNF-α in patients with severe hepatic diseases
- Chinese Journal of Integrative Medicine Vol. 8, Issue 4, Pages: 271-274(2002)
- Affiliations：
  
  Shenzhen East-Lake Hospital,Shenzhen
- Author bio：
- Funds：
  
  This article is supported by Shenzhen Bureau of Sciences and Technics (No. 199904007)
- DOI：10.1007/BF02934403
  CLC：
- Published：2002，
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Wu, QK., Yang, DG., Tao, YY. et al. Effect of Chishao Chengqi decoction on endotoxin and TNF-α in patients with severe hepatic diseases., CJIM 8, 271 (2002). https://doi.org/10.1007/BF02934403

Qi-Kai Wu, Da-Guo Yang, Yan-Yan Tao, et al. Effect of Chishao Chengqi decoction on endotoxin and TNF-α in patients with severe hepatic diseases. [J]. Chinese Journal of Integrative Medicine 8(4):271-274(2002)
Wu, QK., Yang, DG., Tao, YY. et al. Effect of Chishao Chengqi decoction on endotoxin and TNF-α in patients with severe hepatic diseases., CJIM 8, 271 (2002). https://doi.org/10.1007/BF02934403 DOI：

Qi-Kai Wu, Da-Guo Yang, Yan-Yan Tao, et al. Effect of Chishao Chengqi decoction on endotoxin and TNF-α in patients with severe hepatic diseases. [J]. Chinese Journal of Integrative Medicine 8(4):271-274(2002) DOI： 10.1007/BF02934403.

摘要

To observe the effect of Chishao Chengqi decoction (CCD) in treating severe hepatopathy and its influence on serum endotoxin(ET) and tumor necrosis factor a (TNF-α)

in order to explore the possible mechanism of CCD in protecting liver cells and in preventing liver failure. Sixty patients suffering from hepatopathy were divided into the treated group and control group randomly

30 in each group. They were treated with comprehensive treatment

including hepatocyte growth-promoting factors

thymosin

Transmetil and albumin. CCD was given to the treated group additionally. The therapeutic effects were observed and the changes of some biochemical criteria

including alanine transaminase (ALT)

aspartate aminotransferase (AST)

total bilirubin (TB)

albumin (ALB) as well as such parameters as prothrombin activity (PTA)

serum levels of ET and TNF-; were all detected respectively before treatment and after treatment. In the treated group

8 patients was clinically cured after treatment

11 were markedly alleviated

7 improved and 4 remained unchanged

while in the control group

the respective numbers were 5

8 and 9. The total effective rate of the treated group was significantly better than that of the control group by(P<0. 05). ET and TNF-a levels in patients were significantly higher than the normal range before treatment

and they were lowered after treatment. Comparison of the effect between the two groups showed significant difference (P<0.05 )

with that in the treated group better than that in the control group. CCD decoction could reduce the production and releasing of ET and TNF-α in severe hepatopathy patients

which might be one of its therapeutic mechanisms.

Abstract

To observe the effect of Chishao Chengqi decoction (CCD) in treating severe hepatopathy and its influence on serum endotoxin(ET) and tumor necrosis factor a (TNF-α)

30 in each group. They were treated with comprehensive treatment

including hepatocyte growth-promoting factors

thymosin

Transmetil and albumin. CCD was given to the treated group additionally. The therapeutic effects were observed and the changes of some biochemical criteria

including alanine transaminase (ALT)

aspartate aminotransferase (AST)

total bilirubin (TB)

albumin (ALB) as well as such parameters as prothrombin activity (PTA)

serum levels of ET and TNF-; were all detected respectively before treatment and after treatment. In the treated group

8 patients was clinically cured after treatment

11 were markedly alleviated

7 improved and 4 remained unchanged

while in the control group

the respective numbers were 5

and they were lowered after treatment. Comparison of the effect between the two groups showed significant difference (P<0.05 )

with that in the treated group better than that in the control group. CCD decoction could reduce the production and releasing of ET and TNF-α in severe hepatopathy patients

which might be one of its therapeutic mechanisms.

关键词

severe hepatic diseaseChishao Chengqi decoctionendotoxintumor necrosis factor α

Keywords

severe hepatic diseaseChishao Chengqi decoctionendotoxintumor necrosis factor α

references

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Li GX, edit. Pharmacology, Toxicology and Clinical Application of Chinese Drugs. Tianjin: Tianjin Publishing Company of Sciences and Technics, 1992:23,139,161.

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Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences

Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences

Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology

Department of Emergency Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

Department of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences

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