The potential effect of puerarin in preventing atherosclerosis

Qing-Lei Zhu; Ai-Xia He; Hui-Rong Han; Xin-Ran Lu; Shi-Wen Wang

doi:10.1007/BF02934409

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The potential effect of puerarin in preventing atherosclerosis

Updated：2021-08-27

- The potential effect of puerarin in preventing atherosclerosis
- Chinese Journal of Integrative Medicine Vol. 8, Issue 4, Pages: 290-294(2002)
- Affiliations：
  
  1. Institute of Geriatric Cardiology, General Hospital of PLA,Beijing
  2. Department of Anesthesiology, the Affiliated Hospital of Weifang Medical College,China
  3. Applied Pharmacology Laboratory of Weifang Medical College,China
- Author bio：
- Funds：
  
  This study was partially supported by State Key Project of Foundation Research and Development (No.G2000057004)
- DOI：10.1007/BF02934409
  CLC：
- Published：2002，
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Zhu, QL., He, AX., Han, HR. et al. The potential effect of puerarin in preventing atherosclerosis., CJIM 8, 290 (2002). https://doi.org/10.1007/BF02934409

Qing-Lei Zhu, Ai-Xia He, Hui-Rong Han, et al. The potential effect of puerarin in preventing atherosclerosis. [J]. Chinese Journal of Integrative Medicine 8(4):290-294(2002)
Zhu, QL., He, AX., Han, HR. et al. The potential effect of puerarin in preventing atherosclerosis., CJIM 8, 290 (2002). https://doi.org/10.1007/BF02934409 DOI：

Qing-Lei Zhu, Ai-Xia He, Hui-Rong Han, et al. The potential effect of puerarin in preventing atherosclerosis. [J]. Chinese Journal of Integrative Medicine 8(4):290-294(2002) DOI： 10.1007/BF02934409.

摘要

To study the activity of Puerarin (Pue) in scavenging oxygen free radical (OFR) and its inhibitory effect on the oxidative modification of low density lipoprotein (LDL). Riboflavin-light system was used to generate superoxide anion

and Fenton reaction to generate hydroxyl free radical to study the activity of Pue in scavenging OFR. Hydrogen peroxide-induced hemolysis was used to study the effect of Pue on erythrocyte hemolysis and malondialdehyde (MDA) production. And ultraviolet ray and cupric sulfate were used to cause the oxidative modification of LDL for studying the inhibitory effect of Pue on LDL oxidative modification. (1) Pue could

at concentration of 0. 01 – 1.0 mmol/L

scavenge superoxide anion radical and at concentration of 7.5–75μmol/L scavenge hydroxyl radical in a concentration dependent manner. (2) Pue could

at concentration of 0.1–10 mmol/L

inhibit significantly oxidative hemolysis and MDA production of erythrocyte induced by hydrogen peroxide. (3) Pue of 0.01–1.0 mmol/L could inhibit the oxidative modification of LDL in a concentration dependent manner. Pue has an anti-peroxidation effect and shows a potential effect in preventing atherosclerosis.

Abstract

at concentration of 0. 01 – 1.0 mmol/L

scavenge superoxide anion radical and at concentration of 7.5–75μmol/L scavenge hydroxyl radical in a concentration dependent manner. (2) Pue could

at concentration of 0.1–10 mmol/L

关键词

Puerarinantioxidationactive oxygen free radicallow density lipoproteinoxidative modification

Keywords

Puerarinantioxidationactive oxygen free radicallow density lipoproteinoxidative modification

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