Experimental study of Yishou Tiaozhi tablet( ) on inhibiting hyperlipemia and atherosclerosis) on inhibiting hyperlipemia and atherosclerosis

Yi Zhong; Bing-Kuang Zhu; Shi-Fu Zheng

doi:10.1007/BF02935110

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Experimental study of Yishou Tiaozhi tablet( ) on inhibiting hyperlipemia and atherosclerosis) on inhibiting hyperlipemia and atherosclerosis

Updated：2021-08-27

- Experimental study of Yishou Tiaozhi tablet( ) on inhibiting hyperlipemia and atherosclerosis) on inhibiting hyperlipemia and atherosclerosis
- Chinese Journal of Integrative Medicine Vol. 7, Issue 1, Pages: 43-47(2001)
- Affiliations：
  
  1. Guangdong Provincial TCM Hospital,Guangzhou
  2. Institute of Integrated Traditional Chinese and Western Medicine on Qi and Blood in Jinan University,Guangzhou
- Author bio：
- Funds：
- DOI：10.1007/BF02935110
  CLC：
- Published：2001，
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Zhong, Y., Zhu, BK. & Zheng, SF. Experimental study of Yishou Tiaozhi tablet() on inhibiting hyperlipemia and atherosclerosis) on inhibiting hyperlipemia and atherosclerosis., CJIM 7, 43–47 (2001). https://doi.org/10.1007/BF02935110

Yi Zhong, Bing-Kuang Zhu, Shi-Fu Zheng. Experimental study of Yishou Tiaozhi tablet( ) on inhibiting hyperlipemia and atherosclerosis) on inhibiting hyperlipemia and atherosclerosis. [J]. Chinese Journal of Integrative Medicine 7(1):43-47(2001)
Zhong, Y., Zhu, BK. & Zheng, SF. Experimental study of Yishou Tiaozhi tablet() on inhibiting hyperlipemia and atherosclerosis) on inhibiting hyperlipemia and atherosclerosis., CJIM 7, 43–47 (2001). https://doi.org/10.1007/BF02935110 DOI：

Yi Zhong, Bing-Kuang Zhu, Shi-Fu Zheng. Experimental study of Yishou Tiaozhi tablet( ) on inhibiting hyperlipemia and atherosclerosis) on inhibiting hyperlipemia and atherosclerosis. [J]. Chinese Journal of Integrative Medicine 7(1):43-47(2001) DOI： 10.1007/BF02935110.

摘要

Objective: To observe the effect of Yishou Tiaozhi tablet(YSTZT) on lipid metabolism and aortic intimal atherosclerotic plaque coverage in rabbit model of experimental hyperlipemia and atherosclerosis.Methods: Thirty-two rabbits were randomly divided into four groups

Group A

C and D

8 in each group. Forage with cholesterol and lipid plus 1.59 g/kg of YSTZT was fed to Group A every day; for Group B

22.54 mg/kg gypenoside tablet was added to forage with cholesterol and lipid; for Group C

hyperlipid forage was given and for Group D

only ordinary forage was given. Biochemical parameters were measured and pathomorpho-logical examinations were carried out 6 weeks later.Results: (1) YSTZT obviously lowered the levels of serum total cholesterol(TC)

triglyceride(TG)

atherosclerotic index(AI)

apoprotein(ApoB)

lipoprotein [Lp(a)]

oxygen-low density lipoprotein cholesterol (ox-LDL)

hydroxyproline(HYP)

plasma Ca2+

thromboxane B2 (TXB2)

and increased the levels of serum high-density lipoprotein cholesterol(HDL-C)

apoprotein A1 (Apo A1)

ApoA1/ApoB

plasma 6-keto-PGFlα (P < 0.01). (2) Pathomorphological examination showed that in Group A aortic intimal atherosclerotic plaque area and arterial intima thickness were obviously reduced

smooth muscle cell hyperplasia and elastic fibers were not seen.Conclusion: YSTZT can inhibit experimental hyperlipemia and atherogenesis. It is an ideal and effective medicine in preventing and treating hyperlipemia and atherosclerosis.

Abstract

Group A

C and D

8 in each group. Forage with cholesterol and lipid plus 1.59 g/kg of YSTZT was fed to Group A every day; for Group B

22.54 mg/kg gypenoside tablet was added to forage with cholesterol and lipid; for Group C

hyperlipid forage was given and for Group D

triglyceride(TG)

atherosclerotic index(AI)

apoprotein(ApoB)

lipoprotein [Lp(a)]

oxygen-low density lipoprotein cholesterol (ox-LDL)

hydroxyproline(HYP)

plasma Ca2+

thromboxane B2 (TXB2)

and increased the levels of serum high-density lipoprotein cholesterol(HDL-C)

apoprotein A1 (Apo A1)

ApoA1/ApoB

plasma 6-keto-PGFlα (P < 0.01). (2) Pathomorphological examination showed that in Group A aortic intimal atherosclerotic plaque area and arterial intima thickness were obviously reduced

关键词

Yishou Tiaozhi tablethyperlipemiaatherosclerosis

Keywords

Yishou Tiaozhi tablethyperlipemiaatherosclerosis

references

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Department of Traditional Chinese Medicine, Shanghai No. 6 People’s Hospital, Affiliated to Shanghai Jiaotong University

Lab, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou

Department of Cardiology, First Affiliated Hospital of Zhejiang Chinese Medical University

Zhujiang Hospital, Southern Medical University

Integrative Hospital, College of Chinese Medicine, Southern Medical University

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