Effect of shenmai Injection on SIL-2R NK and LAK cells of patients with advanced carcinoma

Feng Pei-fang; Liu Lu-ming; Shen Yu-ying

doi:10.1007/BF02940690

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Effect of shenmai Injection on SIL-2R NK and LAK cells of patients with advanced carcinoma

Updated：2021-08-27

- Effect of shenmai Injection on SIL-2R NK and LAK cells of patients with advanced carcinoma
- Chinese Journal of Integrative Medicine Vol. 1, Issue 4, Pages: 255-257(1995)
- Affiliations：
  
  Zhejiang Provincial Hospital of TCM,Hangzhou
- Author bio：
- Funds：
- DOI：10.1007/BF02940690
  CLC：
- Published：1995，
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Feng, Pf., Liu, Lm. & Shen, Yy. Effect of shenmai Injection on SIL-2R NK and LAK cells of patients with advanced carcinoma., CJIM 1, 255–257 (1995). https://doi.org/10.1007/BF02940690

Feng Pei-fang, Liu Lu-ming, Shen Yu-ying. Effect of shenmai Injection on SIL-2R NK and LAK cells of patients with advanced carcinoma. [J]. Chinese Journal of Integrative Medicine 1(4):255-257(1995)
Feng, Pf., Liu, Lm. & Shen, Yy. Effect of shenmai Injection on SIL-2R NK and LAK cells of patients with advanced carcinoma., CJIM 1, 255–257 (1995). https://doi.org/10.1007/BF02940690 DOI：

Feng Pei-fang, Liu Lu-ming, Shen Yu-ying. Effect of shenmai Injection on SIL-2R NK and LAK cells of patients with advanced carcinoma. [J]. Chinese Journal of Integrative Medicine 1(4):255-257(1995) DOI： 10.1007/BF02940690.

摘要

Serum interleukin-2 receptor (sIL-2R) level

activities of natural killer cell (NK) and lymphokine activated killer (LAK) cells were determined in 60 patients with advanced carcinoma (AC) before and after treatment with Shenmai Injection (SMI)

forty healthy persons were taken as non-carcinoma control (NC). The results showed that: Serum sIL-2R level in AC were much higher than those in NC (P<0.05) and activities of NK and LAK cells in AC were much lower than those in NC (P<0.05) before treatment. There was no significant difference among gastric

colonic and lung cancer (P>0.05). After treatment with SMI

it was found that the level of sIL-2R in all patients were obviously lowered (P<0.05) while the activities of NK and LAK cells were signifficantly higher than that prior the treatment (P<0.05). Relevancy was not found between sIL-2R and NK

LAK cells. These data suggested that the immune function was compromised in AC

and SMI has a wide effect of immuno-regulation.

Abstract

Serum interleukin-2 receptor (sIL-2R) level

activities of natural killer cell (NK) and lymphokine activated killer (LAK) cells were determined in 60 patients with advanced carcinoma (AC) before and after treatment with Shenmai Injection (SMI)

colonic and lung cancer (P>0.05). After treatment with SMI

LAK cells. These data suggested that the immune function was compromised in AC

and SMI has a wide effect of immuno-regulation.

关键词

Shenmai injectionadvanced carcinomasoluble interleukin-2 receptorlymphokine activated killer cellNatural Killer Cell

Keywords

Shenmai injectionadvanced carcinomasoluble interleukin-2 receptorlymphokine activated killer cellNatural Killer Cell

references

Araden L, Production of hybridoma growth factor by human monocytes. EurJ Immunol 1987;17:141.

Philips JH, Lanier II. Dissection of the lymphokine activated killer phenomenon relative contribution of peripheral blood natural killer cells and T-lymphocytes to cytolysis. J Exp Med 1986;164:814.

Laurence A. The soluble IL-2 receptor biology, function and clinical application. Annals of Internal Medicine 1990;113:619.

Nelson DL. Soluble IL-2R: analysis in normal individuals and in certain disease state. Fed Proc 1987;45:377.

Mrino P. Increased levels of sIL-2R in serum of patients with lung cancer. B J Cancer 1990;61(3):434.

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Emergency Medicine Department, Integrated Chinese and Western Medicine Hospital, Zhejiang University of Traditional Chinese Medicine

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. for Research on the Theory of Qi-Blood of Integrated Medicine, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing

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