Effects of dachengqi decoction (大承气汤) and rhubarb on cellular electrical activity in the smooth muscle of guinea-pig taenia coli

Yang Wen-xiu; Jin Zheng-gen; Yu Qi; Xu Wen-Sheng; Ni Hong-yan; Yu Hai-ying; Tian Zai-shan

doi:10.1007/BF02947292

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Effects of dachengqi decoction (大承气汤) and rhubarb on cellular electrical activity in the smooth muscle of guinea-pig taenia coli

Updated：2021-08-27

- Effects of dachengqi decoction (大承气汤) and rhubarb on cellular electrical activity in the smooth muscle of guinea-pig taenia coli
- Chinese Journal of Integrative Medicine Vol. 1, Issue 1, Pages: 56-58(1995)
- Affiliations：
  
  1. Biophysics Division, Nankai University,Tianjin
  2. Tianjin Institute of Acute Abdomen with Integrated Traditional and Western Medicine,Tianjin
- Author bio：
- Funds：
  
  Project supported by grant from Science and Technique Committee of Tianjin, China
- DOI：10.1007/BF02947292
  CLC：
- Published：1995，
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Yang, Wx., Jin, Zg., Yu, Q. et al. Effects of dachengqi decoction (大承气汤) and rhubarb on cellular electrical activity in the smooth muscle of guinea-pig taenia coli., CJIM 1, 56–58 (1995). https://doi.org/10.1007/BF02947292

Yang Wen-xiu, Jin Zheng-gen, Yu Qi, et al. Effects of dachengqi decoction (大承气汤) and rhubarb on cellular electrical activity in the smooth muscle of guinea-pig taenia coli. [J]. Chinese Journal of Integrative Medicine 1(1):56-58(1995)
Yang, Wx., Jin, Zg., Yu, Q. et al. Effects of dachengqi decoction (大承气汤) and rhubarb on cellular electrical activity in the smooth muscle of guinea-pig taenia coli., CJIM 1, 56–58 (1995). https://doi.org/10.1007/BF02947292 DOI：

Yang Wen-xiu, Jin Zheng-gen, Yu Qi, et al. Effects of dachengqi decoction (大承气汤) and rhubarb on cellular electrical activity in the smooth muscle of guinea-pig taenia coli. [J]. Chinese Journal of Integrative Medicine 1(1):56-58(1995) DOI： 10.1007/BF02947292.

摘要

The effects of Dachengqi decoction (DCQ) and rhubarb (Rb) on the spontaneous cellular electrical activities of guinea-pig taenia coli have been studied by intracellular microelectrode technique. DCQ and Rb both improve the depolarization of cell membrane

speed up the burst of slow wave and spike potentials (when the drug concentration was 1%

P>0.05

10% or 20%

P<0.05)

which were dose dependent. At the same concentration the effects of Rb were more significant than those of DCQ. These results suggest DCQ and Rb directly enhance the cellular electrical excitability so as to strengthen the contraction of the colon

is one of the mechanisms of the purgative action of these drugs at the cellular level. The ionic basis of the effects might be that DCQ and Rb reduce the K+ conductance of the cell membranes in a resting state.

Abstract

speed up the burst of slow wave and spike potentials (when the drug concentration was 1%

P>0.05

10% or 20%

P<0.05)

关键词

Dachengqi decoctionrhubarbsmooth musclemicroelectrodesintracellular recordingslow wave potentialspike potential

Keywords

Dachengqi decoctionrhubarbsmooth musclemicroelectrodesintracellular recordingslow wave potentialspike potential

references

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Hunter M, et al. Calcium-activated K-channels amphiuma early distal tubule inhibition of ATP. Pflugers Archiv 1988;412:331.

Barajas-Lopez C, et al. Role of the sodium pump in generation of pacemaker generation in dog colonic smooth muscle. J Physiol 1989;416:369.

Barajas-Lopez C, et al. Ionic basis of pacemaker generation in the dog colon smooth muscle. J Physiol 1989;416:385.

Barajas-Lopez C, et al. Different mechanisms of contraction generation in the colonic smooth muscle. Am J Physiol 1989;256:G570.

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