Effect of tongbiling on the synoviocyte function in adjuvant arthritis rats

Jifan Chen; Huifang Zhao; Xiaoyan Shen; Songhua Li; Yingmin Li; Shihuang Liao; Yangmo Huang; Hideki Okunishi; Lianqun Qiu; Tong Guan; Yongqi Fang; Xiaoling Liu

doi:10.1007/BF02973147

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Effect of tongbiling on the synoviocyte function in adjuvant arthritis rats

Updated：2021-08-27

- Effect of tongbiling on the synoviocyte function in adjuvant arthritis rats
- Chinese Journal of Integrative Medicine Vol. 6, Issue 1, Pages: 43-46(2000)
- Affiliations：
  
  1. The First Affiliated Hospital of Guangzhou University of TCM,Guangzhou
  2. Shimane Medical University,Japan
- Author bio：
- Funds：
  
  This program was supported by the Nature Science Foundation of Guangdong Province (No. 960550)
- DOI：10.1007/BF02973147
  CLC：
- Published：2000，
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Chen, J., Zhao, H., Shen, X. et al. Effect of tongbiling on the synoviocyte function in adjuvant arthritis rats., CJIM 6, 43–46 (2000). https://doi.org/10.1007/BF02973147

Jifan Chen, Huifang Zhao, Xiaoyan Shen, et al. Effect of tongbiling on the synoviocyte function in adjuvant arthritis rats. [J]. Chinese Journal of Integrative Medicine 6(1):43-46(2000)
Chen, J., Zhao, H., Shen, X. et al. Effect of tongbiling on the synoviocyte function in adjuvant arthritis rats., CJIM 6, 43–46 (2000). https://doi.org/10.1007/BF02973147 DOI：

Jifan Chen, Huifang Zhao, Xiaoyan Shen, et al. Effect of tongbiling on the synoviocyte function in adjuvant arthritis rats. [J]. Chinese Journal of Integrative Medicine 6(1):43-46(2000) DOI： 10.1007/BF02973147.

摘要

Objective: To study the effect of Tongbiling (TBL) on the proliferation of synovial fibroblast and interleukin-1 (IL-1)

tumor necrosis factor-α (TNF-α) and prostaglandin E2(PGE2) secreted by synoviocytes in adjuvant arthritis (AA) rats.Methods: Synovial fibroblast was derived from culture of tissue piece. The effect of primary synoviocyte culture supernatants on the fibroblast proliferation were assayed and IL-1

TNF-α bioactivity and PGE2 content of supernatants of cultured synoviocytes were measured.Results: TBL could significantly inhibit the synovial fibroblast proliferation (P < 0.001)

and down-regulate IL-1

TNF-α and PGE2 productions (P < 0. 001); indomethacin could obviously promote the synovial fibroblast proliferation (P < 0.001). It significantly inhibited PGE2 production

but further up-regulated IL-1 and TNF-α secreted by synoviocytes (P<0.01).Conclusion: The therapeutical effect of TBL on AA might be associated with its down-regulating the secretory function of synoviocyte

then restoring the abnormal proliferation of fibroblast to normal levels.

Abstract

Objective: To study the effect of Tongbiling (TBL) on the proliferation of synovial fibroblast and interleukin-1 (IL-1)

TNF-α bioactivity and PGE2 content of supernatants of cultured synoviocytes were measured.Results: TBL could significantly inhibit the synovial fibroblast proliferation (P < 0.001)

and down-regulate IL-1

TNF-α and PGE2 productions (P < 0. 001); indomethacin could obviously promote the synovial fibroblast proliferation (P < 0.001). It significantly inhibited PGE2 production

then restoring the abnormal proliferation of fibroblast to normal levels.

关键词

Adjuvant Arthritissynovial membranecell culturefibroblastcell proliferationcytokineTongbiling

Keywords

Adjuvant Arthritissynovial membranecell culturefibroblastcell proliferationcytokineTongbiling

references

Gitter BD, Lees SI, Scheetz ME. Characteristics of human synovial fibroblast activation by IL-1β and TNF-α. Immunology 1989;66(2): 196–200.

Li SH, Kobayashi Y, Yamauchi Y, et al. Suppressive effects of TBL on phalangeal destruction of type II collagen-induced arthritis mice. Japanese J of Clin Rheum 1993; 5:123–125.

Li SH, Kobayashi Y, Yamauchi Y, et al. Suppressive effects of a herbal formula TBL-1 on type II collagen-induced arthritis in DBA/IJ mice. Clin Exp Pharmacol Physiol 1996;20:236–240.

Chen JF, Zhao HF, Liao SH, et al. Tongbiling for the treatment of rheumatoid arthritis: An observation of 137 cases. J New TCM 1997; 9(9): 13–14.

Wang B, Chen MZ, Xu SY. Effect of total glycosides of peony on synoviocyte function and splenocyte proliferation in adjuvant arthritis rats. Chin J Pharmacol Toxicol 1994;8(2): 128–131.

Wang B, Chen MZ. The effect of synoviocyte culture supernatants on the fibroblast proliferation. Anhui J Acta Academic Med 1997;32(5):534–536.

Yu MX, Zhang LH, Shi L, et al. IL-1 and TNF-α bioassay and PGE2 immunoassay of supernatant of cultured synovia in patients with rheumatic disease. Acta Acad Med Sinica 1994; 16(3): 192 -193.

Cai Q, Meng JM. The role of IL-1 and TNF in rheumatoid arthritis. Shanghai J Immunol 1998; 18(1): 62–63.

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Department of Rheumatism and Immunity, the First Hospital Affiliated to Anhui College of Traditional Chinese Medicine

Department of Gerontology, Beijing Friendship Hospital, Capital Medical University

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