Effect of Kangxin Capsule (康欣胶囊) on the expression of nerve growth factors in parietal lobe of cortex and hippocampus CA1 area of vascular dementia model rats

Cai  Jing; Du Jian; Ge Zhen-hua; Zhou Fan; Zhou Lin-yin; Chen Lian-yun

doi:10.1007/s11655-001-0292-9

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Effect of Kangxin Capsule (康欣胶囊) on the expression of nerve growth factors in parietal lobe of cortex and hippocampus CA1 area of vascular dementia model rats

Updated：2021-08-27

- Effect of Kangxin Capsule (康欣胶囊) on the expression of nerve growth factors in parietal lobe of cortex and hippocampus CA1 area of vascular dementia model rats
- Chinese Journal of Integrative Medicine Vol. 12, Issue 4, Pages: 292-296(2006)
- Affiliations：
  
  1. Institute of Geriatrics, Fujian College of Traditional Chinese Medicine,Fuzhou,China
  2. Fujian Institute of Traditional Chinese Medicine,China
  3. Department of Electron Microscope, Fujian Medical University,China
- Author bio：
- Funds：
  
  Key Project supported by Health Bureau of Fujian Province (2002-101), Fujian Innovation Project for Young Scientific Talents (2002J055), Fujian Education Committee (JA02237).
- DOI：10.1007/s11655-001-0292-9
  CLC：
- Published：2006，
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Cai, J., Du, J., Ge, Zh. et al. Effect of Kangxin Capsule (康欣胶囊) on the expression of nerve growth factors in parietal lobe of cortex and hippocampus CA1 area of vascular dementia model rats., Chin. J Integ. Med. 12, 292–296 (2006). https://doi.org/10.1007/s11655-001-0292-9

Cai Jing, Du Jian, Ge Zhen-hua, et al. Effect of Kangxin Capsule (康欣胶囊) on the expression of nerve growth factors in parietal lobe of cortex and hippocampus CA1 area of vascular dementia model rats. [J]. Chinese Journal of Integrative Medicine 12(4):292-296(2006)
Cai, J., Du, J., Ge, Zh. et al. Effect of Kangxin Capsule (康欣胶囊) on the expression of nerve growth factors in parietal lobe of cortex and hippocampus CA1 area of vascular dementia model rats., Chin. J Integ. Med. 12, 292–296 (2006). https://doi.org/10.1007/s11655-001-0292-9 DOI：

Cai Jing, Du Jian, Ge Zhen-hua, et al. Effect of Kangxin Capsule (康欣胶囊) on the expression of nerve growth factors in parietal lobe of cortex and hippocampus CA1 area of vascular dementia model rats. [J]. Chinese Journal of Integrative Medicine 12(4):292-296(2006) DOI： 10.1007/s11655-001-0292-9.

摘要

To observe the effect of Kangxin Capsule (康欣胶囊

KXC) on the expression of nerve growth factor (NGF) as well as the morphology and amount of nerve synapse in the cortical parietal lobe and hippocampus CA1 area of vascular dementia (VD) model rats. The model rats of VD made by photochemical reaction technique were randomly divided into five groups: the model group (MG)

the high-dose

middle-dose and low-dose KXC groups (HDG

MDG and LDG)

and the Western medicine hydergin control group (WMG). They were treated respectively with distilled water

high

middle and low dosage of KXC suspended liquid

and hydergin for a month. Besides

a blank group consisting of normal (non-model) rats was set up for control (CG). The ultrastructure of nerve synapse in the cortical partietal lobe and hippocampus CA1 area of the rats were observed and its density estimated. The condition of NGF positive neurons in the above-mentioned two regions were also observed by immunohistochemical stain. All the KXC or hydergin treated groups demonstrated a normal amount of nerve synapse with integral structure in the cortical parietal lobe and hippocampus CA1 area

which approached that in the CG and was superior to that in the MG. Also

the NGF positive neuron in all the treated groups was much more than that in MG with significant difference (P<0.01)

approaching to that in the CG. KXC could elevate the expression of NGF in the cortical parietal lobe and hippocampus CA1 area

preserve the number and morphology of synapse

thus to protect the function of nerve system from ischemic injury.

Abstract

To observe the effect of Kangxin Capsule (康欣胶囊

the high-dose

middle-dose and low-dose KXC groups (HDG

MDG and LDG)

and the Western medicine hydergin control group (WMG). They were treated respectively with distilled water

high

middle and low dosage of KXC suspended liquid

and hydergin for a month. Besides

which approached that in the CG and was superior to that in the MG. Also

the NGF positive neuron in all the treated groups was much more than that in MG with significant difference (P<0.01)

approaching to that in the CG. KXC could elevate the expression of NGF in the cortical parietal lobe and hippocampus CA1 area

preserve the number and morphology of synapse

thus to protect the function of nerve system from ischemic injury.

关键词

Kangxin CapsuleVascular DementiaNerve Growth Factornerve synapseultrastructure

Keywords

Kangxin CapsuleVascular DementiaNerve Growth Factornerve synapseultrastructure

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Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine

The Second Hospital Affiliated to Tianjin University of Traditional Chinese Medicine

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Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University

Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences

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