Effect of sodium ferulate on fluidity and morphology of cell membrane in ozone induced lung injury

Wang  De jun; Dai Xiao-jun; Xu Feng; Sun Yun

doi:10.1007/s11655-001-0297-4

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Effect of sodium ferulate on fluidity and morphology of cell membrane in ozone induced lung injury

Updated：2021-08-27

- Effect of sodium ferulate on fluidity and morphology of cell membrane in ozone induced lung injury
- Chinese Journal of Integrative Medicine Vol. 12, Issue 4, Pages: 297-300(2006)
- Affiliations：
  
  Medical College, Yangzhou University,Jiangsu,China
- Author bio：
- Funds：
  
  Supported by Science and Technology Committee of Jiangsu Province (No. BK98135113)
- DOI：10.1007/s11655-001-0297-4
  CLC：
- Published：2006，
Scan for full text
Wang, D.j., Dai, Xj., Xu, F. et al. Effect of sodium ferulate on fluidity and morphology of cell membrane in ozone induced lung injury., Chin. J Integ. Med. 12, 297–300 (2006). https://doi.org/10.1007/s11655-001-0297-4

Wang De jun, Dai Xiao-jun, Xu Feng, et al. Effect of sodium ferulate on fluidity and morphology of cell membrane in ozone induced lung injury. [J]. Chinese Journal of Integrative Medicine 12(4):297-300(2006)
Wang, D.j., Dai, Xj., Xu, F. et al. Effect of sodium ferulate on fluidity and morphology of cell membrane in ozone induced lung injury., Chin. J Integ. Med. 12, 297–300 (2006). https://doi.org/10.1007/s11655-001-0297-4 DOI：

Wang De jun, Dai Xiao-jun, Xu Feng, et al. Effect of sodium ferulate on fluidity and morphology of cell membrane in ozone induced lung injury. [J]. Chinese Journal of Integrative Medicine 12(4):297-300(2006) DOI： 10.1007/s11655-001-0297-4.

摘要

To study the effect of sodium ferulate (SF)

an active component of Radix Angelica

on lung damage induced by ozone (O3). Mice model of lung injury was induced by ozone inhalation and treated with SF. The level of lipid peroxide and microviscosity in alveolar epithelial cell membrane of the mice was determined

and the structural change of lung cells was observed by microscopy. Ozone could increase the level of malondialdehyde (MDA) and the microviscosity in alveolar epithelial cell membrane

and induce inflammatory changes in morphologic structure. These abnormal changes were improved after SF administration

which was manifested as alleviation of heightened microviscosity

increase of membrane fluidity

as well as the basically normalized pulmonary cellular structure under microscope. SF has a preventive effect against oxidized pulmonary injury induced by ozone

the action of which could be through scavenging oxygen free radicals

reducing lipid peroxide production

increasing membranous fluidity and mitigating inflammatory changes in cell structure.

Abstract

To study the effect of sodium ferulate (SF)

an active component of Radix Angelica

and the structural change of lung cells was observed by microscopy. Ozone could increase the level of malondialdehyde (MDA) and the microviscosity in alveolar epithelial cell membrane

and induce inflammatory changes in morphologic structure. These abnormal changes were improved after SF administration

which was manifested as alleviation of heightened microviscosity

increase of membrane fluidity

as well as the basically normalized pulmonary cellular structure under microscope. SF has a preventive effect against oxidized pulmonary injury induced by ozone

the action of which could be through scavenging oxygen free radicals

reducing lipid peroxide production

increasing membranous fluidity and mitigating inflammatory changes in cell structure.

关键词

sodium ferulateozonemalondialdehydemembranous fluiditymorphology

Keywords

sodium ferulateozonemalondialdehydemembranous fluiditymorphology

references

Liu XQ, Lu YC, Pang QF. Injury of ozone in mice. Chin J Ind Hyg Occup Dis 1990; 8(8): 365–367.

Jing H, Yao LY, Li JS, et al. Pharmacology research of sodium ferulate in China. Northwest Pharm J 2002; 17(5): 236–238.

Sun Y, Wang DJ, Shen SQ, et al. Effect of Cistanche Deserticacity in Xinjiang on ultrastructure of liver and cerebral cortex observed by transmission electron microscope in aging mice. Tradit Chin Drug Res Clin Pharmacol 1997; 8(1): 30–31.

Guo ZZ, editor. A kind of rapid ageing model. Annual Collection of Society of Pathology in Beijing 1986;1986: 8.

Yin LP, Liu XL, Qi XT, et al. Molecular biological technique. Beijing: Capital Normal University Publication Society 2001: 86–89,102–105.

Sun Y, Wang DJ, Zhu J, et al. Effect of Cistanche Desertica Polysacchrides on the constitution of protein anti-oxidative capacity of lung in aging mice. Chin Pharmacol Bull 2001;17(1): 101–103.

Zhou PL, editor. Erythrocyte membrane fluidity detemined by fluorescence intensity. In: Biophysics Experiment edited by Zhang ZH and Liu WL. Shanghai: Fudan University Publishing Company, 1991: 81–84.

Wang JB. Measurement of size distribution and microviscosity of diplamitoyl cyclocytidine liposome. Fine Chem 2006;23(2): 154–157.

Schartz LW. Pulmonary responses of rats to ambient levels of ozone. Lab Invest 1986: 34(6): 256–264.

Liu F. Fluidity of flutacet erethrocytes determined by fluorescent probe DPH. Acta Nanjing Med Univ 1996;16(6): 527–529.

Hu XL, Wang H, Wu JL. Protection and mechanism of sodium ferulate on CCl4 induced liver injury in mice. Chin J Clin Pharmacol Ther 2004; 9(1): 74–76.

Sun Y, Xu F, Zhang HQ. Study on the pharmacological mechanism of sodium ferulate for anti-asthmatic effect in guinea pigs.Chin J Integr Tradit West Med 2004;20(11): 1103–1105.

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Related Author

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Related Institution

Medical College of Yangzhou University

Department of Cardiology, the Tangshan Worker’s Hospital of Hebei Medical University

Medical Research Center, Hebei United University

Department of Obstetrics, Beijing Fangshan District Maternal and Child Health Hospital

Department of Internal Medicine, Hebei Medical University

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