Effects of Jinye Baidu Granule (金叶败毒颗粒) on fetal growth and development with maternal active human cytomegalovirus infection

Jiang  Hong; Chen Su-hua; Wen Liang-zhen

doi:10.1007/s11655-006-0250-3

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Effects of Jinye Baidu Granule (金叶败毒颗粒) on fetal growth and development with maternal active human cytomegalovirus infection

Updated：2021-08-27

- Effects of Jinye Baidu Granule (金叶败毒颗粒) on fetal growth and development with maternal active human cytomegalovirus infection
- Chinese Journal of Integrative Medicine Vol. 12, Issue 4, Pages: 250-254(2006)
- Affiliations：
  
  1. Department of Gynecology and Obstetrics, the 105th Hospital of PLA,Hefei,China
  2. Department of Gynecology and Obstetrics, Tongji Hospital, Huazhong University of Science and Technology,China
- Author bio：
- Funds：
  
  Supported by the National Key Technology Research and Development Program of China during the 9th Five-Year Plan Period (No. 96-904-06-08)
- DOI：10.1007/s11655-006-0250-3
  CLC：
- Published：2006，
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Jiang, H., Chen, Sh. & Wen, Lz. Effects of Jinye Baidu Granule (金叶败毒颗粒) on fetal growth and development with maternal active human cytomegalovirus infection., Chin. J Integ. Med. 12, 250–254 (2006). https://doi.org/10.1007/s11655-006-0250-3

Jiang Hong, Chen Su-hua, Wen Liang-zhen. Effects of Jinye Baidu Granule (金叶败毒颗粒) on fetal growth and development with maternal active human cytomegalovirus infection. [J]. Chinese Journal of Integrative Medicine 12(4):250-254(2006)
Jiang, H., Chen, Sh. & Wen, Lz. Effects of Jinye Baidu Granule (金叶败毒颗粒) on fetal growth and development with maternal active human cytomegalovirus infection., Chin. J Integ. Med. 12, 250–254 (2006). https://doi.org/10.1007/s11655-006-0250-3 DOI：

Jiang Hong, Chen Su-hua, Wen Liang-zhen. Effects of Jinye Baidu Granule (金叶败毒颗粒) on fetal growth and development with maternal active human cytomegalovirus infection. [J]. Chinese Journal of Integrative Medicine 12(4):250-254(2006) DOI： 10.1007/s11655-006-0250-3.

摘要

To evaluate the effects of Jinye Baidu Granule (金叶败毒颗粒

JYBDG)

a traditional Chinese medicine compound prescription

on fetal growth and development with maternal active human cytomegalovirus infection. A prospective

randomized and controlled trial was adopted during January 1996 to June 2002. From the pregnant women with an abnormal pregnant history

240 cases were screened to be infected by human cytomegalovirus (HCMV) by enzyme-linked immunoabsorbent assay (ELISA) and reverse transcription polymerase chain reaction (RT-PCR). They were assigned according to the random number table to two groups. The 122 cases in the treatment group were administrated with JYBDG

one package each time

three times a day for two continuous weeks

while the other 118 in the control group did not receive any treatment. The negative conversion rate of both HCMV-IgM and HCMV late mRNA

the positive rate of HCMV-DNA in placenta and the intrauterine transmission rate between the two groups were compared

and fetal growth and development in partial fetuses were also observed. The negative conversion rate of both HCMV-IgM and HCMV late mRNA

the positive rate of HCMV-DNA in placenta and the intrauterine transmission rate in the treatment group were 77.05% (94/122)

48.98% (48/98) and 21.74% (10/46) respectively

while those in the control group were 38.14% (45/118)

67.50% (54/80) and 52.63% (20/38) respectively

all showing significant difference between the two groups (P<0.01). Totally 35 normal infants and 11 abnormal infants were born in the treatment group

and the number in the control group was 20 and 18 respectively

and comparison between the two groups showed significant difference (P<0.01). Six months of child birth

the scores of both mental development index (MDI) and psychomotor development index (PDI) of infants were higher in the treatment group (20 cases) than those in the control group (20 cases)

but there was no significant difference between the two groups (P>0.05). JYBDG could decrease the intrauterine transmission of HCMV and is beneficial to fetal growth and development.

Abstract

To evaluate the effects of Jinye Baidu Granule (金叶败毒颗粒

JYBDG)

a traditional Chinese medicine compound prescription

on fetal growth and development with maternal active human cytomegalovirus infection. A prospective

randomized and controlled trial was adopted during January 1996 to June 2002. From the pregnant women with an abnormal pregnant history

one package each time

three times a day for two continuous weeks

while the other 118 in the control group did not receive any treatment. The negative conversion rate of both HCMV-IgM and HCMV late mRNA

the positive rate of HCMV-DNA in placenta and the intrauterine transmission rate between the two groups were compared

and fetal growth and development in partial fetuses were also observed. The negative conversion rate of both HCMV-IgM and HCMV late mRNA

the positive rate of HCMV-DNA in placenta and the intrauterine transmission rate in the treatment group were 77.05% (94/122)

48.98% (48/98) and 21.74% (10/46) respectively

while those in the control group were 38.14% (45/118)

67.50% (54/80) and 52.63% (20/38) respectively

all showing significant difference between the two groups (P<0.01). Totally 35 normal infants and 11 abnormal infants were born in the treatment group

and the number in the control group was 20 and 18 respectively

and comparison between the two groups showed significant difference (P<0.01). Six months of child birth

the scores of both mental development index (MDI) and psychomotor development index (PDI) of infants were higher in the treatment group (20 cases) than those in the control group (20 cases)

but there was no significant difference between the two groups (P>0.05). JYBDG could decrease the intrauterine transmission of HCMV and is beneficial to fetal growth and development.

关键词

Chinese Herbal Medicinecytomegalovirusintrauterine infectionfetal growth and developmentJinye Baidu Granule

Keywords

Chinese Herbal Medicinecytomegalovirusintrauterine infectionfetal growth and developmentJinye Baidu Granule

references

Wen LZ, Wu SM, Lu SM, et al. The epidemiological study on human cytomegalovirus infection of pregnant women and the maternal-fetal transmission in three Chinese metropolis. Chin J Obstet Gynecol 1996; 31(12): 714–717.

Gozlan J, Salord JM, Chouaid C, et al. Human cytomegalovirus (HCMV) late-mRNA detection in peripheral blood of AIDS patients: Diagnostic value for HCMV disease compared with those of viral culture and HCMV DNA detection. J Clin Microbiol 1993;31(7): 1943–1945.

Jiang H, Wen LZ. Detection of human cytomegalovirus late-mRNA by reverse transcription polymerase chain reaction. Chin J Med Lab Sci 1998; 21(4): 246.

He JM, Ao LM, Bao KR, et al. The short-term follow-up of infants with asymptomatic congenital HCMV infections. Chin J Pediatr 1998; 36(1): 37–39.

Kaplan C. The placenta and viral infection. Clin Obtest Gynecol 1990; 33(2): 232–241.

Chen SH, Wen LZ, Feng L, et al. Exploring on the correlation between HCMV infection of placenta and fetal growth. Chin J Prac Obstet Gynecol 1996; 12(5): 277–278.

Jiang H, Wen LZ, Lin XZ. Experimental and clinical study of inhibitory effects of Reduqing on human cytomegalovirus. Clin J New Drugs Clin Rem 2005;24(10): 769–773.

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Cardiovascular Diseases Centre, Xiyuan Hospital, China Academy of Chinese Medical Sciences

The First Affiliated Hospital of Medical College of Zhejiang University

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Department of Chinese Medicine, Beijing Children’s Hospital Affiliated to Capital University of Medical Sciences

Institute of Integrative Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

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