Effects of Shehuang Paste(麝黄膏) on hemodynamics, endotoxin, nitric oxide and endothelin-1 in patients with refractory cirrhotic ascites

Tong Guang-dong; Zhou  Da-qiao; He Jin-song; Li Song-lin; Peng Li-sheng

doi:10.1007/s11655-006-0255-4

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Effects of Shehuang Paste(麝黄膏) on hemodynamics, endotoxin, nitric oxide and endothelin-1 in patients with refractory cirrhotic ascites

Updated：2021-08-27

- Effects of Shehuang Paste(麝黄膏) on hemodynamics, endotoxin, nitric oxide and endothelin-1 in patients with refractory cirrhotic ascites
- Chinese Journal of Integrative Medicine Vol. 12, Issue 4, Pages: 255-261(2006)
- Affiliations：
  
  Department of Hepatology, Shenzhen Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine,China
- Author bio：
- Funds：
  
  Supported by State Administration of TCM (No. 02-03LP40)
- DOI：10.1007/s11655-006-0255-4
  CLC：
- Published：2006，
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Tong, Gd., Zhou, Dq., He, Js. et al. Effects of Shehuang Paste(麝黄膏) on hemodynamics, endotoxin, nitric oxide and endothelin-1 in patients with refractory cirrhotic ascites., Chin. J Integ. Med. 12, 255–261 (2006). https://doi.org/10.1007/s11655-006-0255-4

Tong Guang-dong, Zhou Da-qiao, He Jin-song, et al. Effects of Shehuang Paste(麝黄膏) on hemodynamics, endotoxin, nitric oxide and endothelin-1 in patients with refractory cirrhotic ascites. [J]. Chinese Journal of Integrative Medicine 12(4):255-261(2006)
Tong, Gd., Zhou, Dq., He, Js. et al. Effects of Shehuang Paste(麝黄膏) on hemodynamics, endotoxin, nitric oxide and endothelin-1 in patients with refractory cirrhotic ascites., Chin. J Integ. Med. 12, 255–261 (2006). https://doi.org/10.1007/s11655-006-0255-4 DOI：

Tong Guang-dong, Zhou Da-qiao, He Jin-song, et al. Effects of Shehuang Paste(麝黄膏) on hemodynamics, endotoxin, nitric oxide and endothelin-1 in patients with refractory cirrhotic ascites. [J]. Chinese Journal of Integrative Medicine 12(4):255-261(2006) DOI： 10.1007/s11655-006-0255-4.

摘要

To explore the influence of Shehuang Paste (麝黄膏

SHP) to the hemodynamics

endotoxin

nitric oxide (NO)

and endothelin-1 (ET-1) in patients with refractory cirrhotic ascites. Fifty-nine cases of refractory cirrhotic ascites were randomly assigned to two groups

32 cases in the treatment group and 27 cases in the control group. The basic treatment was the same for both groups

including liver protecting medicines

diuretics and supportive drugs

but SHP navel sticking was applied for the treatment group additionally once a day. A course of one month of treatment was applied and the general efficacy on ascites was observed by the end of the therapeutic course. Before and after the treatment

examinations by limulus lysate chromogenic test was conducted to measure plasma endotoxin content; colorimetry to measure plasma content of NO indirectly

radioimmunoassay to measure plasma ET-1 content; and color Doppler ultrasonography to measure the blood flow of portal vein and splenic vein. The relationship between the blood flow of portal vein and splenic vein and endotoxin

NO and ET-1 in the treatment group was analyzed as well. The total effective rate on ascites was 84.4% in the treatment group

and 48.1% in the control group

with significant difference shown between them (P<0.01). In the treatment group the blood flow of portal vein and splenic vein

contents of endotoxin

NO and ET-1 all got significantly reduced after treatment (P<0.05 or P<0.01); while these indexes in the control group were not significantly changed (P>0.05). Moreover

it was found that in the treatment group

the blood flow of portal vein and splenic vein had a positive correlation to the levels of NO

ET-1

and endotoxin

either before or after treatment. Application of SHP navel sticking could clearly reduce the blood flow of portal vein and splenic vein

and lower the content of endotoxin

NO and ET-1. The blood flow of portal vein and splenic vein in the treatment group showed a positive correlation with the contents of endotoxin

NO and ET-1.

Abstract

To explore the influence of Shehuang Paste (麝黄膏

SHP) to the hemodynamics

endotoxin

nitric oxide (NO)

and endothelin-1 (ET-1) in patients with refractory cirrhotic ascites. Fifty-nine cases of refractory cirrhotic ascites were randomly assigned to two groups

32 cases in the treatment group and 27 cases in the control group. The basic treatment was the same for both groups

including liver protecting medicines

diuretics and supportive drugs

examinations by limulus lysate chromogenic test was conducted to measure plasma endotoxin content; colorimetry to measure plasma content of NO indirectly

NO and ET-1 in the treatment group was analyzed as well. The total effective rate on ascites was 84.4% in the treatment group

and 48.1% in the control group

with significant difference shown between them (P<0.01). In the treatment group the blood flow of portal vein and splenic vein

contents of endotoxin

NO and ET-1 all got significantly reduced after treatment (P<0.05 or P<0.01); while these indexes in the control group were not significantly changed (P>0.05). Moreover

it was found that in the treatment group

the blood flow of portal vein and splenic vein had a positive correlation to the levels of NO

ET-1

and endotoxin

either before or after treatment. Application of SHP navel sticking could clearly reduce the blood flow of portal vein and splenic vein

and lower the content of endotoxin

NO and ET-1. The blood flow of portal vein and splenic vein in the treatment group showed a positive correlation with the contents of endotoxin

NO and ET-1.

关键词

liver cirrhosisrefractory ascitesvasoactive substancehemodynamics

Keywords

liver cirrhosisrefractory ascitesvasoactive substancehemodynamics

references

Liang KH, Li SB. Portal hypertension. Beijing: People’ s Military Medical Press, 1999: 192.

Moreau R. Hepatorenal syndrome in patients with cirrhosis. J Gastroenterol Hepatol 2002; 17(7): 739–774.

Wang JY. Modern treatment of hepatology. Shanghai: Shanghai Medical University Publishing House, 1999: 244.

Lv XP, Zhan LL, Jiang HH. Effect of changes of nitric oxide, endothelin and antidiuretic hormone on portal hypertension induced by hepatic cirrhosis. Clin Focus 2000;15(11): 384–386.

Chen MZ, Jiang ZM. Water and electrolyte balance in clinic. 2nd ed. Beijing: People’ s Medical Publishing House, 2000: 156.

Zhang XL, Ye XC. Research on navel sticking and recent developments. Chin J Med 1997; 32(12): 38–40.

Hu DS, Qian J, Jia H. Observation of efficacy of Xiaopeng Powder navel stickingin treating cirrhotic ascites. Tianjin J TCM 2001;17(4): 201–203.

Zhang SB, Wen PK. Study on extraction of Moschus from Shehuang-Babuji. China Pharmacy 2005;16(14): 1117–1118.

Liu LL, Zhang W. Clinical significance of portal haemodynamics using pulsed-wave Doppler. Med J Communication 1996;10(2): 18–20.

Special Committee of Internal Heptatology, China Association of Chinese Medicine. Standards for efficacy evaluation of TCM on liver cirrhosis ascites (Draft). 1993: 101–103.

Vyas K, Gala B, Sawant P, et al. Assessment of portal hemodynamics by ultrasound colorized Doppler and laser Doppler velocimetry in liver cirrhosis. Indian J Gastroenterol 2002;21(5): 176–178.

Chu CJ, Lee FY, Wang SS, et al. Splanchnic endotoxin levels in cirrhotic rats induced by carbon tetrachloride. Zhonghua Yi Xue Za Zhi (Taipei) 2000; 63(3): 196–204.

Spahr L, Martin PY, Giostra E, et al. Acute effects of nitric oxide synthase inhibition on systemic, hepatic, and renal hemodynamics in patients with cirrhosis and ascites. J Invest Med 2002; 50(2): 116–124.

Such J, Frances R, Perez-Mateo M. Nitric oxide in patients with cirrhosis and bacterial infections. Metab Brain Dis 2002;7(4): 303–309.

Gan HS, Chen YQ, Wu Y. The changes and clinical significance of nitric oxide in patients with cirrhosis. West Chin Med J 2000;15(4): 154.

Jiangsu New Medical College. A Chinese materia medica dictionary 1995: 2741, 648, 415, 2316.

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