Treatment of 37 patients with refractory idiopathic thrombocytopenic purpura by Shengxueling (升血灵)

Shao Ke-ding; Zhou  Yu-hong; Shen Yi-ping; Ye Bao-dong; Gao Rui-Ian; Zhang Yu

doi:10.1007/s11655-007-0033-9

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Treatment of 37 patients with refractory idiopathic thrombocytopenic purpura by Shengxueling (升血灵)

Updated：2021-08-27

- Treatment of 37 patients with refractory idiopathic thrombocytopenic purpura by Shengxueling (升血灵)
- Chinese Journal of Integrative Medicine Vol. 13, Issue 1, Pages: 33-36(2007)
- Affiliations：
  
  Department of Hematology, the First Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine,Hangzhou,China
- Author bio：
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- DOI：10.1007/s11655-007-0033-9
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- Published：2007，
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Shao, Kd., Zhou, Yh., Shen, Yp. et al. Treatment of 37 patients with refractory idiopathic thrombocytopenic purpura by Shengxueling (升血灵)., Chin. J Integ. Med. 13, 33–36 (2007). https://doi.org/10.1007/s11655-007-0033-9

Shao Ke-ding, Zhou Yu-hong, Shen Yi-ping, et al. Treatment of 37 patients with refractory idiopathic thrombocytopenic purpura by Shengxueling (升血灵). [J]. Chinese Journal of Integrative Medicine 13(1):33-36(2007)
Shao, Kd., Zhou, Yh., Shen, Yp. et al. Treatment of 37 patients with refractory idiopathic thrombocytopenic purpura by Shengxueling (升血灵)., Chin. J Integ. Med. 13, 33–36 (2007). https://doi.org/10.1007/s11655-007-0033-9 DOI：

Shao Ke-ding, Zhou Yu-hong, Shen Yi-ping, et al. Treatment of 37 patients with refractory idiopathic thrombocytopenic purpura by Shengxueling (升血灵). [J]. Chinese Journal of Integrative Medicine 13(1):33-36(2007) DOI： 10.1007/s11655-007-0033-9.

摘要

To explore the clinical effect and possible mechanism of Shengxueling (升血灵

SXL)

a Chinese medical preparation mainly consisting of ginseng saponins

in treating refractory idiopathic thrombocytopenic purpura (ITP). The selected 69 patients with ITP were randomly assigned to two groups

the 37 patients in the treated group were treated orally by SXL with the dose for adult as 60 mg twice a day for two weeks. Then when no marked rise of platelet count after that

the dose would be doubled and administered for another two weeks. Then the dose could be gradually reduced to the initiative level in patients who responded to the treatment

and if they did not

the treatment was regarded as ineffective and be terminated. The 32 patients in the control group were treated with ampeptide elemente instead of SXL

0.4 g each time three times a day in the first two weeks

and

if that was ineffective

0.2 g would be added each time and 1.8 g would be administered a day for two more weeks. Four weeks’ treatment was regarded as one therapeutic course for both groups and the observation lasted for two successive courses in patients showing positive response. In the 37 patients in the treated group

markedly effective was obtained in 7 (19.0%)

favorably effective in 15 (40.5%)

improved in 5 (13.5%) and ineffective in 10 (27.0%)

the total effective rate being 59.5%. The corresponding number in the 32 patients in the control group was 4 (12.5%)

6 (18.8%)

3 (9.4%)

19 (59.4%) and 31.3% respectively. Comparison showed the difference in therapeutic efficacy between the two groups was significant (P<0.05). SXL is a safe and effective preparation for treatment of ITP

showing an immediate effect which is obviously superior to that of ampeptide elemente with less adverse effect.

Abstract

To explore the clinical effect and possible mechanism of Shengxueling (升血灵

SXL)

a Chinese medical preparation mainly consisting of ginseng saponins

in treating refractory idiopathic thrombocytopenic purpura (ITP). The selected 69 patients with ITP were randomly assigned to two groups

the 37 patients in the treated group were treated orally by SXL with the dose for adult as 60 mg twice a day for two weeks. Then when no marked rise of platelet count after that

the dose would be doubled and administered for another two weeks. Then the dose could be gradually reduced to the initiative level in patients who responded to the treatment

and if they did not

the treatment was regarded as ineffective and be terminated. The 32 patients in the control group were treated with ampeptide elemente instead of SXL

0.4 g each time three times a day in the first two weeks

and

if that was ineffective

markedly effective was obtained in 7 (19.0%)

favorably effective in 15 (40.5%)

improved in 5 (13.5%) and ineffective in 10 (27.0%)

the total effective rate being 59.5%. The corresponding number in the 32 patients in the control group was 4 (12.5%)

6 (18.8%)

3 (9.4%)

showing an immediate effect which is obviously superior to that of ampeptide elemente with less adverse effect.

关键词

Idiopathic Thrombocytopenic Purpurarefractabilityginseng saponins

Keywords

Idiopathic Thrombocytopenic Purpurarefractabilityginseng saponins

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Institute of Hematology, The First Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine

Yueyang Hospital of Integrated Traditional and Western Medicine, Shanghai University of TCM

Department of Hematology, Hexi Hospital

Beijing Hospital, National Center for Clinical Laboratories

Institute of Materia Medica, Chinese Academy of Medical Sciences

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