Effect of Huanglian Jiedu Decoction (黄连解毒汤) on glucose transporter 4 expression in adipose and skeletal muscle tissues of insulin resistant rats

Chen Guang; Lu  Fu-er; Jin Dan; Xu Li-jun; Wang Kai-fu

doi:10.1007/s11655-007-0041-9

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Effect of Huanglian Jiedu Decoction (黄连解毒汤) on glucose transporter 4 expression in adipose and skeletal muscle tissues of insulin resistant rats

Updated：2021-08-27

- Effect of Huanglian Jiedu Decoction (黄连解毒汤) on glucose transporter 4 expression in adipose and skeletal muscle tissues of insulin resistant rats
- Chinese Journal of Integrative Medicine Vol. 13, Issue 1, Pages: 41-45(2007)
- Affiliations：
  
  Institute of Integrative Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of P. R. China (No. 30371816) and Specialized Research Fund for the Doctoral Program of Higher Education (No. 20030487008)
- DOI：10.1007/s11655-007-0041-9
  CLC：
- Published：2007，
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Chen, G., Lu, Fe., Jin, D. et al. Effect of Huanglian Jiedu Decoction (黄连解毒汤) on glucose transporter 4 expression in adipose and skeletal muscle tissues of insulin resistant rats., Chin. J Integ. Med. 13, 41–45 (2007). https://doi.org/10.1007/s11655-007-0041-9

Chen Guang, Lu Fu-er, Jin Dan, et al. Effect of Huanglian Jiedu Decoction (黄连解毒汤) on glucose transporter 4 expression in adipose and skeletal muscle tissues of insulin resistant rats. [J]. Chinese Journal of Integrative Medicine 13(1):41-45(2007)
Chen, G., Lu, Fe., Jin, D. et al. Effect of Huanglian Jiedu Decoction (黄连解毒汤) on glucose transporter 4 expression in adipose and skeletal muscle tissues of insulin resistant rats., Chin. J Integ. Med. 13, 41–45 (2007). https://doi.org/10.1007/s11655-007-0041-9 DOI：

Chen Guang, Lu Fu-er, Jin Dan, et al. Effect of Huanglian Jiedu Decoction (黄连解毒汤) on glucose transporter 4 expression in adipose and skeletal muscle tissues of insulin resistant rats. [J]. Chinese Journal of Integrative Medicine 13(1):41-45(2007) DOI： 10.1007/s11655-007-0041-9.

摘要

To investigate the effects of Huanglian Jiedu Decoction (黄连解毒汤

HLJDD) on glucose transporter 4 (GLUT4) protein expressions in insulin-resistant murine target tissues. The experimental male Wistar rats were established into insulin resistant models by injecting streptozotocin (STZ 30 mg/kg) via caudal vein and feeding them with high fat high caloric diet

and randomly divided into the model group

the aspirin group and the HLJDD group. Besides

a normal group was set up for control. Changes of body weight (BW)

levels of serum fasting blood glucose (FBG)

serum fasting insulin (FINS) and oral glucose tolerance test (OGTT) were routinely determined. The expression of GLUT4 protein in adipose and skeletal muscle tissues before and after insulin stimulation was determined with Western blot. In the HLJDD group after treatment

BW and FBG got decreased

OGTT improved

and the expression and translocation of GLUT4 protein elevated obviously

either before or after insulin stimulation

as compared with those in the model group

showing significant differences respectively. The mechanism of improving insulin resistance by HLJDD is probably associated with its effect in elevating GLUT4 protein expression and translocation in adipose and skeletal muscle tissues of insulin resistant rats.

Abstract

To investigate the effects of Huanglian Jiedu Decoction (黄连解毒汤

and randomly divided into the model group

the aspirin group and the HLJDD group. Besides

a normal group was set up for control. Changes of body weight (BW)

levels of serum fasting blood glucose (FBG)

BW and FBG got decreased

OGTT improved

and the expression and translocation of GLUT4 protein elevated obviously

either before or after insulin stimulation

as compared with those in the model group

关键词

Huanglian Jiedu Decoctionglucose transporter 4insulin resistancetarget tissue

Keywords

Huanglian Jiedu Decoctionglucose transporter 4insulin resistancetarget tissue

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Xiamen Diabetes Institute

Department of Internal Medicine, the First Affiliated Hospital of Xiamen University

Post-Graduate School, Fujian University of Traditional Chinese Medicine

Pharmaceutical College of Harbin Commercial University

Institute of Integrated Traditional and Western Medicine, Affiliated to Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology

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