To assess the effect and safety of nano-Amoni Paste (nmAP) in the treatment of children’s anorexia (AR). One hundred and eighty patients of AR were assigned according to the randomized

double-blinded

double-simulated and parallel controlled principle to three groups

the treated group (TG)

the positive control group (PCG) and the negative control group (NCG)

60 in each group. The patients in TG were treated by sticking 1.5 ml of nmAP on the acupoint of Shenque (Ren 8) once a day and orally taking placebo liquid 10 ml twice a day; those in PCG and NCG treated with sticking paste of placebo on Ren 8

and oral taking of Shanmai Jianpi Oral Liquid (山麦健脾口服液) and placebo liquid respectively

10 ml each time twice per day. The course of treatment for all was 10 days

all patients were treated for 2 courses. The total effective rate and the effective rate on cardinal symptom in TG was 85.0% and 95.0% respectively

that in PCG 86.2% and 96.55% and in NCG 45.5% and 65.45%

respectively

showing significant difference between groups (P<0.05). Comparison of the clinical manifestation before and after treatment showed significant improvement in volume of food intake

appetite

complexion and reduction of restlessness symptom (P<0.05) in all three groups

and there was no adverse reaction found in them. nmAP is an effective and safe remedy for treatment of Children’s anorexia.