Expressions of VEGF and Ki-67 in eutopic endometrium of patients with endometriosis and effect of Quyu Jiedu Recipe (祛瘀解毒方) on VEGF expression

Lian  Fang; Liu Hai-ping; Wang Yun-xia; Zhang Jian-wei; Sun Zhen-gao; Ma Feng-mei; Zhang Ning; Liu Yan-he; Meng Qian

doi:10.1007/s11655-007-0109-6

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Expressions of VEGF and Ki-67 in eutopic endometrium of patients with endometriosis and effect of Quyu Jiedu Recipe (祛瘀解毒方) on VEGF expression

Updated：2021-08-27

- Expressions of VEGF and Ki-67 in eutopic endometrium of patients with endometriosis and effect of Quyu Jiedu Recipe (祛瘀解毒方) on VEGF expression
- Chinese Journal of Integrative Medicine Vol. 13, Issue 2, Pages: 109-114(2007)
- Affiliations：
  
  1. Reproduction Center, Affiliated Hospital of Shandong University of TCM,Jinan,China
  2. Shandong University of TCM,China
  3. Shandong Provincial Academy of Medical Sciences,China
- Author bio：
- Funds：
  
  Supported by Research Projects of Medical Science and Hygiene of Shandong Province 1999 (No. 42)
- DOI：10.1007/s11655-007-0109-6
  CLC：
- Published：2007，
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Lian, F., Liu, Hp., Wang, Yx. et al. Expressions of VEGF and Ki-67 in eutopic endometrium of patients with endometriosis and effect of Quyu Jiedu Recipe (祛瘀解毒方) on VEGF expression., Chin. J Integ. Med. 13, 109–114 (2007). https://doi.org/10.1007/s11655-007-0109-6

Lian Fang, Liu Hai-ping, Wang Yun-xia, et al. Expressions of VEGF and Ki-67 in eutopic endometrium of patients with endometriosis and effect of Quyu Jiedu Recipe (祛瘀解毒方) on VEGF expression. [J]. Chinese Journal of Integrative Medicine 13(2):109-114(2007)
Lian, F., Liu, Hp., Wang, Yx. et al. Expressions of VEGF and Ki-67 in eutopic endometrium of patients with endometriosis and effect of Quyu Jiedu Recipe (祛瘀解毒方) on VEGF expression., Chin. J Integ. Med. 13, 109–114 (2007). https://doi.org/10.1007/s11655-007-0109-6 DOI：

Lian Fang, Liu Hai-ping, Wang Yun-xia, et al. Expressions of VEGF and Ki-67 in eutopic endometrium of patients with endometriosis and effect of Quyu Jiedu Recipe (祛瘀解毒方) on VEGF expression. [J]. Chinese Journal of Integrative Medicine 13(2):109-114(2007) DOI： 10.1007/s11655-007-0109-6.

摘要

To observe the clinical efficacy of Quyu Jiedu Recipe (祛瘀解毒方

QJR) in treating endometriosis (EM)

and to explore the levels of vascular endothelial growth factor (VEGF) and cell proliferative nucleoprotein antigen (Ki-67)

their changes before and after treatment and the clinical significance in the trial. Fifty patients of EM were randomly assigned to two groups. The 26 patients in the QJR group were treated with QJR

and the 24 patients in the gestrinone (GT) group with gestrinone. Besides

a normal control group with 20 healthy women was set up. The therapeutic effects in the two treated groups were compared. Expressions of VEGF and Ki-67 in eutopic endometrium of all subjects (with both patients and healthy women at the median secretive phase) were determined with immunohistochemical stain before treatment

and the determination in the two treated groups was repeated after 3-month treatment in the same phase. Before treatment

the VEGF and Ki-67 expression positive rates and their mean optic density (MOD) were higher in patients than in healthy women (P<0.05). After treatment

the positive rate and MOD of VEGF expression lowered significantly than before treatment (P<0.05)

but those of Ki-67 changed insignificantly

and comparison between the two treated groups showed no significant difference (P>0.05). QJR could markedly improve the symptoms of menorrhagia and menstrual disorder

and its mechanism might be related with the lowering of eutopic endometrial VEGF expression. VEGF and Ki-67 show a high expression in eutopic endometrium of patients with EM.

Abstract

To observe the clinical efficacy of Quyu Jiedu Recipe (祛瘀解毒方

QJR) in treating endometriosis (EM)

and to explore the levels of vascular endothelial growth factor (VEGF) and cell proliferative nucleoprotein antigen (Ki-67)

their changes before and after treatment and the clinical significance in the trial. Fifty patients of EM were randomly assigned to two groups. The 26 patients in the QJR group were treated with QJR

and the 24 patients in the gestrinone (GT) group with gestrinone. Besides

and the determination in the two treated groups was repeated after 3-month treatment in the same phase. Before treatment

the VEGF and Ki-67 expression positive rates and their mean optic density (MOD) were higher in patients than in healthy women (P<0.05). After treatment

the positive rate and MOD of VEGF expression lowered significantly than before treatment (P<0.05)

but those of Ki-67 changed insignificantly

and comparison between the two treated groups showed no significant difference (P>0.05). QJR could markedly improve the symptoms of menorrhagia and menstrual disorder

and its mechanism might be related with the lowering of eutopic endometrial VEGF expression. VEGF and Ki-67 show a high expression in eutopic endometrium of patients with EM.

关键词

endometriosisQuyu Jiedu Recipestagnancy of toxinvascular endothelial growth factorKi-67

Keywords

endometriosisQuyu Jiedu Recipestagnancy of toxinvascular endothelial growth factorKi-67

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Department of Obstetrics and Gynecology, PLA Navy General Hospital

Department of Gynecology, Second Affiliated Hospital to Tianjin University of Traditional Chinese Medicine

Department of Gynecology, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijng

Department of Gynecology, Fuxing Hospital, Capital Medical University

Department of Obstetrics and Gynecology, Beijing Tiantan Hospital Affiliated to Capital Medical University

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