To study the effect and mechanism of mexican tea herb and pilular adina herb (abbreviated to MP) on concrescence of gastric mucosa in experimental gastric ulcer rats by observing the changes of epidermal growth factor (EGF)

nitrogen monoxidum (NO) and expression of epidermal growth factor receptor (EGFR). The rat ulcer model was established by 100% glacial acetic injection into the subserosa. The ulcer index (UI) was measured by sliding caliper. The levels of NO and EGF in tissue and serum were measured by the nitrate reductase method and enzyme-linked immunosorbent assay

respectively. The expression of EGFR in the mucosa around the ulcer was detected by the immunohistochemical assay and microimage analysis system. (1) Compared with the model group

UI of MP groups (10

15 and 20 mg·kg−1·d−1) and ranitidine group was lower (P<0.05 or P<0.01)

the levels of NO and EGF in the tissue and serum were higher (P<0.05)

the thickness of regenerated mucous membrane increased

and the width loss of lamina muscularis mucosa decreased (all P<0.05). (2) The expression of EGFR is weakly positive in gastric mucosa cells in the normal group

mainly in the cytoplasm and cytomembrane. In the model group

the expression of EGFR was mainly in epithelial cells in cervical part and basilar part of gastric gland around the ulcer margin

and the number of cells with EGFR weakly positive expression was more than that in the normal group. Compared with that in the normal and model groups

the number of cells with EGFR positive in MP groups and ranitidine group increased (all P<0.05)

with weakly positive expression. MP can protect gastric mucosa

cure gastric ulcer

restrain the secretion of gastric acid

and boost multiplication

differentiation

migration and repair of the endothelial cell by promoting the secretion of NO and EGF

and increasing the expression of EGFR of gastric mucosa epithelial cells.