Protective effect of tanshinone II A on lipopolysaccharide-induced lung injury in rats

Shi  Xue-mei; Huang Liang; Xiong Sheng-dao; Zhong Xian-yang

doi:10.1007/s11655-007-0137-2

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Protective effect of tanshinone II A on lipopolysaccharide-induced lung injury in rats

Updated：2021-08-27

- Protective effect of tanshinone II A on lipopolysaccharide-induced lung injury in rats
- Chinese Journal of Integrative Medicine Vol. 13, Issue 2, Pages: 137-140(2007)
- Affiliations：
  
  1. Department of Respiratory Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China
  2. Department of Emergency, First Affiliated Hospital to Jiangxi Medical College,China
  3. Department of Nephrology, The Hospital of PLA,Guangzhou,China,421
- Author bio：
- Funds：
- DOI：10.1007/s11655-007-0137-2
  CLC：
- Published：2007，
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Shi, Xm., Huang, L., Xiong, Sd. et al. Protective effect of tanshinone II A on lipopolysaccharide-induced lung injury in rats., Chin. J Integ. Med. 13, 137–140 (2007). https://doi.org/10.1007/s11655-007-0137-2

Shi Xue-mei, Huang Liang, Xiong Sheng-dao, et al. Protective effect of tanshinone II A on lipopolysaccharide-induced lung injury in rats. [J]. Chinese Journal of Integrative Medicine 13(2):137-140(2007)
Shi, Xm., Huang, L., Xiong, Sd. et al. Protective effect of tanshinone II A on lipopolysaccharide-induced lung injury in rats., Chin. J Integ. Med. 13, 137–140 (2007). https://doi.org/10.1007/s11655-007-0137-2 DOI：

Shi Xue-mei, Huang Liang, Xiong Sheng-dao, et al. Protective effect of tanshinone II A on lipopolysaccharide-induced lung injury in rats. [J]. Chinese Journal of Integrative Medicine 13(2):137-140(2007) DOI： 10.1007/s11655-007-0137-2.

摘要

To explore the protective effect of tanshinone II A on lipopolysaccharide (LPS)-induced lung injury in rats

and possible mechanism. LPS (O111: B4) was used to produce a rat model of acute lung injury. Sprague-Dawley rats were randomly divided into 3 groups (8 in each group): the control group

the model group (ALI group)

and the tanshinone II A treatment group. Expression of adhesion molecule CD18 on the surface of polymorphonuclear neutrophil (PMNCD18) in venous white blood cells (WBC)

and changes in coagulation-anticoagulant indexes were measured 6 h after injection of LPS or normal saline. Changes in malondialdehyde (MDA) content

wet and dry weight (W/D) ratio and morphometry of pulmonary tissue as well as PMN sequestration in the lung were also measured. (1) When compared with the control group

expression of PMNCD18 and MDA content were enhanced in the ALI group with a hypercoagulable state (all P<0.01) and an increased W/D ratio (P<0.05). Histopathological morphometry in the lung tissue showed higher PMN sequestration

wider alveolar septa; and lower alveolar volume density (VV) and alveolar surface density (SV)

showing signifi cant difference (P<0.01). (2) When compared with the ALI group

the expression of PMN-CD18

MDA content

and W/D ratio were all lower in Tanshinone II A treatment group (P<0.05) with ameliorated coagulation abnormality (P<0.01). Histopathological morphometry in the lung tissue showed a decrease in the PMN sequestration and the width of alveolar septa (both P<0.01)

and an increase in the VV and SV (P<0.05

P<0.01). Tan II A plays a protective role in LPS-induced lung injury in rats through improving hypercoagulating state

decreasing PMN-CD18 expression and alleviating migration

reducing lipid peroxidation and alleviating pathological changes.

Abstract

To explore the protective effect of tanshinone II A on lipopolysaccharide (LPS)-induced lung injury in rats

and possible mechanism. LPS (O111: B4) was used to produce a rat model of acute lung injury. Sprague-Dawley rats were randomly divided into 3 groups (8 in each group): the control group

the model group (ALI group)

and the tanshinone II A treatment group. Expression of adhesion molecule CD18 on the surface of polymorphonuclear neutrophil (PMNCD18) in venous white blood cells (WBC)

and changes in coagulation-anticoagulant indexes were measured 6 h after injection of LPS or normal saline. Changes in malondialdehyde (MDA) content

wet and dry weight (W/D) ratio and morphometry of pulmonary tissue as well as PMN sequestration in the lung were also measured. (1) When compared with the control group

wider alveolar septa; and lower alveolar volume density (VV) and alveolar surface density (SV)

showing signifi cant difference (P<0.01). (2) When compared with the ALI group

the expression of PMN-CD18

MDA content

and an increase in the VV and SV (P<0.05

P<0.01). Tan II A plays a protective role in LPS-induced lung injury in rats through improving hypercoagulating state

decreasing PMN-CD18 expression and alleviating migration

reducing lipid peroxidation and alleviating pathological changes.

关键词

CD18 adhesion moleculeAcute Lung Injurytanshinone II Amalondialdehydecoagulation abnormality

Keywords

CD18 adhesion moleculeAcute Lung Injurytanshinone II Amalondialdehydecoagulation abnormality

references

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Shi XM, Huang L. β2-integrin and acute lung injury. Chin J Crit Care Med 2004; 24(7): 42–43.

Wang AM, Sha SH, Lesniak W, et al. Tanshinone (Salviae miltiorrhizae extract) preparations attenuate aminoglycoside-induced free radical formation in vitro and ototoxicity in vivo. Antimicrob Agents Chemother 2003; 47(6): 1836–1841.

Zhong XY, Luo R, Wei LB, et al. The effect of Tanshinone-II A against renal reperfusion injury reperfusion injury following haemorrhagic shock in rats. Chin J Integr Tradit West Nephrol 2001; 3(1): 13–15.

Abraham E. Coagulation abnormalities in acute lung injury and sepsis. Am J Respir Cell Mol Biol 2000; 22(3): 401–401.

Gardinali M, Borrelli E, Chiara O, et al. Inhibition of CD11–CD18 complex prevents acute lung injury and reduces mortality after peritonitis in rabbits. Am J Respir Crit Care Med 2000; 161: 1022–1029.

Jiang KY, Geng RC, Lun GZ. Effects of tanshinone-II A sulfonate on adhension molecule expression of endothelial cells and platelets in vitro. Acta Pharm Sin 1998; 19(1): 47–50.

Liu JJ, Lin DJ, Liu PQ, et al. Induction of apoptosis and inhibition of cell adhesive and invasive effects by tanshinone II A in acute promyelocytic leukemia cells in vitro. J Biomed Sci 2006; 13(3): 813–823.

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