Study on the efficacy and safety of Xueyou Mixture (血友合剂) in treating hemophilia

Liu  Shan-xi; Jiang Lin; Liu Yi-guo; He Yue-qin; Liang Xin; Kong Wei-wei; Chen Jing

doi:10.1007/s11655-007-0141-6

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Study on the efficacy and safety of Xueyou Mixture (血友合剂) in treating hemophilia

Updated：2021-08-27

- Study on the efficacy and safety of Xueyou Mixture (血友合剂) in treating hemophilia
- Chinese Journal of Integrative Medicine Vol. 13, Issue 2, Pages: 141-144(2007)
- Affiliations：
  
  Shanxi YiDa Institute of Hematopathy,Xi’an,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-007-0141-6
  CLC：
- Published：2007，
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Liu, Sx., Jiang, L., Liu, Yg. et al. Study on the efficacy and safety of Xueyou Mixture (血友合剂) in treating hemophilia., Chin. J Integ. Med. 13, 141–144 (2007). https://doi.org/10.1007/s11655-007-0141-6

Liu Shan-xi, Jiang Lin, Liu Yi-guo, et al. Study on the efficacy and safety of Xueyou Mixture (血友合剂) in treating hemophilia. [J]. Chinese Journal of Integrative Medicine 13(2):141-144(2007)
Liu, Sx., Jiang, L., Liu, Yg. et al. Study on the efficacy and safety of Xueyou Mixture (血友合剂) in treating hemophilia., Chin. J Integ. Med. 13, 141–144 (2007). https://doi.org/10.1007/s11655-007-0141-6 DOI：

Liu Shan-xi, Jiang Lin, Liu Yi-guo, et al. Study on the efficacy and safety of Xueyou Mixture (血友合剂) in treating hemophilia. [J]. Chinese Journal of Integrative Medicine 13(2):141-144(2007) DOI： 10.1007/s11655-007-0141-6.

摘要

To observe the effect of Xueyou Mixture (血友合剂

XYM) on blood coagulation factors and its safety in treating hemophilia. To the randomly selected 65 inpatients of hemophilia

XYM was administered accompanied with intravenous dripping of liver cell growth factor 60–100 mg once a day to protect the liver

with no blood products like concentrated VIII and FIX factors or blood plasma given. The treatment lasted for 3 weeks. The short-term efficacy and adverse reactions were observed. The long-term efficacy in patients was observed in a follow-up study of 6–12 months after they were discharged from the hospital but continuously took XYM orally. The short-term markedly effective rate in the patients was 95.38% (62/65). After they were treated for 3 weeks

the level of FVIII factor activity increased in 56 patients of type A from (3.32±2.21) % to (4.18±2.23) %

and in 9 of type B from (4.92±1.81) % to (5.64±1.96) %. Compared with that before treatment

the difference was signifi cant in both of them (P<0.01). No obvious adverse reaction was found in the treatment period. The follow-up study showed that in 22 patients of type A

the FVIII factor activity ratio increased from (3.25±2.11) % to (6.31±2.16) %

(8.36±1.05) %

and (16.38±2.71) % in the 2nd

3rd and 6th month after discharge respectively

all showing significant difference to that before treatment (P<0.01); and in 4 patients of type B

it increased from (4.15±2.26) % to 7.8% and 11.6% (mean value) in the 2nd and 6th month respectively. XYM could raise the activity of factors VIII and IX in patients with hemophilia

and the degree of the rise is related with the duration of the therapy

with no obvious adverse reaction

which strikes out a new path and new train of thinking for the treatment of the disease by nonblood preparation.

Abstract

To observe the effect of Xueyou Mixture (血友合剂

XYM) on blood coagulation factors and its safety in treating hemophilia. To the randomly selected 65 inpatients of hemophilia

XYM was administered accompanied with intravenous dripping of liver cell growth factor 60–100 mg once a day to protect the liver

the level of FVIII factor activity increased in 56 patients of type A from (3.32±2.21) % to (4.18±2.23) %

and in 9 of type B from (4.92±1.81) % to (5.64±1.96) %. Compared with that before treatment

the difference was signifi cant in both of them (P<0.01). No obvious adverse reaction was found in the treatment period. The follow-up study showed that in 22 patients of type A

the FVIII factor activity ratio increased from (3.25±2.11) % to (6.31±2.16) %

(8.36±1.05) %

and (16.38±2.71) % in the 2nd

3rd and 6th month after discharge respectively

all showing significant difference to that before treatment (P<0.01); and in 4 patients of type B

it increased from (4.15±2.26) % to 7.8% and 11.6% (mean value) in the 2nd and 6th month respectively. XYM could raise the activity of factors VIII and IX in patients with hemophilia

and the degree of the rise is related with the duration of the therapy

with no obvious adverse reaction

which strikes out a new path and new train of thinking for the treatment of the disease by nonblood preparation.

关键词

Xueyou Mixturehemophiliatherapeutic efficacy

Keywords

Xueyou Mixturehemophiliatherapeutic efficacy

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Institute of Integrated Traditional and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

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