Exploration of the relationship between phlegm-dampness constitution and polymorphism of low density lipoprotein receptor genes Pvu II and Ava II

Zhou Jing; Luo Hai-ming

doi:10.1007/s11655-007-0170-1

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Exploration of the relationship between phlegm-dampness constitution and polymorphism of low density lipoprotein receptor genes Pvu II and Ava II

Updated：2021-08-27

- Exploration of the relationship between phlegm-dampness constitution and polymorphism of low density lipoprotein receptor genes Pvu II and Ava II
- Chinese Journal of Integrative Medicine Vol. 13, Issue 3, Pages: 170-174(2007)
- Affiliations：
  
  Department of Internal Cardiology, Yueyang Hospital of Integrative Chinese and Western Medicine, Shanghai University of TCM,Shanghai,China
- Author bio：
- Funds：
  
  Supported by the State Administration of TCM (No. 2003LHR18)
- DOI：10.1007/s11655-007-0170-1
  CLC：
- Published：2007，
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Zhou, J., Luo, Hm. Exploration of the relationship between phlegm-dampness constitution and polymorphism of low density lipoprotein receptor genes Pvu II and Ava II., Chin. J. Integr. Med. 13, 170–174 (2007). https://doi.org/10.1007/s11655-007-0170-1

Zhou Jing, Luo Hai-ming. Exploration of the relationship between phlegm-dampness constitution and polymorphism of low density lipoprotein receptor genes Pvu II and Ava II. [J]. Chinese Journal of Integrative Medicine 13(3):170-174(2007)
Zhou, J., Luo, Hm. Exploration of the relationship between phlegm-dampness constitution and polymorphism of low density lipoprotein receptor genes Pvu II and Ava II., Chin. J. Integr. Med. 13, 170–174 (2007). https://doi.org/10.1007/s11655-007-0170-1 DOI：

Zhou Jing, Luo Hai-ming. Exploration of the relationship between phlegm-dampness constitution and polymorphism of low density lipoprotein receptor genes Pvu II and Ava II. [J]. Chinese Journal of Integrative Medicine 13(3):170-174(2007) DOI： 10.1007/s11655-007-0170-1.

摘要

To explore the polymorphism of low density lipoprotein receptor (LDL-R) genes Pvu II and Ava II in a population with phlegm-dampness constitution (PDC). Polymorphism of LDL-R genes at Pvu II and Ava II of 48 persons with gentle constitution (GC) and 61 with PDC were analyzed with PCR-RELP technique

and their serum contents of lipids and glucose were determined and compared as well. The A+ allelic and P-allelic frequency were higher and the P+ allelic frequency was lower in subjects with PDC than those in subjects with GC

which were 0.3083 vs 0.1771

0.9098 vs 0.7708 and 0.0902 vs 0.2292

respectively

all showing significant difference between the two groups (P<0.05). Comparison of the two groups in serum levels of triglyceride (TG)

fasting blood glucose

2 h postprandial blood glucose

and 2 h postprandial insulin showed that all the parameters were higher in subjects with PDC than in subjects with GC respectively

showing significant difference (P<0.05). PDC is related with the P− and A+ allelic frequency of higher LDL-R genes at Pvu II and Ava II

therefore

the polymorphism of LDL-R genes could be taken as one of the genetic markers for PDC

and humans with PDC are more liable to suffer from blood lipids and glucose disorder than those with GC.

Abstract

which were 0.3083 vs 0.1771

0.9098 vs 0.7708 and 0.0902 vs 0.2292

respectively

all showing significant difference between the two groups (P<0.05). Comparison of the two groups in serum levels of triglyceride (TG)

fasting blood glucose

2 h postprandial blood glucose

and 2 h postprandial insulin showed that all the parameters were higher in subjects with PDC than in subjects with GC respectively

showing significant difference (P<0.05). PDC is related with the P− and A+ allelic frequency of higher LDL-R genes at Pvu II and Ava II

therefore

the polymorphism of LDL-R genes could be taken as one of the genetic markers for PDC

and humans with PDC are more liable to suffer from blood lipids and glucose disorder than those with GC.

关键词

phlegm-dampness constitutionpolymorphism of low density lipoprotein receptor gene

Keywords

phlegm-dampness constitutionpolymorphism of low density lipoprotein receptor gene

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