Effect of modified Wuzi Yanzong Granule (加味五子衍宗颗粒) on patients with mild cognitive impairment from oxidative damage aspect

Wang Xue-mei; Fu Hong; Liu Geng-xin; Zhu Wei; Li Li; Yang Jin-xia

doi:10.1007/s11655-007-0258-7

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Effect of modified Wuzi Yanzong Granule (加味五子衍宗颗粒) on patients with mild cognitive impairment from oxidative damage aspect

Updated：2021-08-27

- Effect of modified Wuzi Yanzong Granule (加味五子衍宗颗粒) on patients with mild cognitive impairment from oxidative damage aspect
- Chinese Journal of Integrative Medicine Vol. 13, Issue 4, Pages: 258-263(2007)
- Affiliations：
  
  Department of Integrated Chinese and Western Medicine of Peking University First Hospital,Beijing,China
- Author bio：
- Funds：
  
  Supported by Capital Key Science and Technology Program for the Development of Medicine (No. 03-II-04)
- DOI：10.1007/s11655-007-0258-7
  CLC：
- Published：2007，
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Wang, Xm., Fu, H., Liu, Gx. et al. Effect of modified Wuzi Yanzong Granule (加味五子衍宗颗粒) on patients with mild cognitive impairment from oxidative damage aspect., Chin. J. Integr. Med. 13, 258–263 (2007). https://doi.org/10.1007/s11655-007-0258-7

Wang Xue-mei, Fu Hong, Liu Geng-xin, et al. Effect of modified Wuzi Yanzong Granule (加味五子衍宗颗粒) on patients with mild cognitive impairment from oxidative damage aspect. [J]. Chinese Journal of Integrative Medicine 13(4):258-263(2007)
Wang, Xm., Fu, H., Liu, Gx. et al. Effect of modified Wuzi Yanzong Granule (加味五子衍宗颗粒) on patients with mild cognitive impairment from oxidative damage aspect., Chin. J. Integr. Med. 13, 258–263 (2007). https://doi.org/10.1007/s11655-007-0258-7 DOI：

Wang Xue-mei, Fu Hong, Liu Geng-xin, et al. Effect of modified Wuzi Yanzong Granule (加味五子衍宗颗粒) on patients with mild cognitive impairment from oxidative damage aspect. [J]. Chinese Journal of Integrative Medicine 13(4):258-263(2007) DOI： 10.1007/s11655-007-0258-7.

摘要

To observe the effects of modified Wuzi Yanzong Granule (加味五子衍宗颗粒

WYG) on memory function and the activity of serum superoxide dismutase (SOD)

malondialdehyde (MDA) levels

leukocyte mitochondrial DNA (mtDNA) deletion rate and β-amyloid protein1–28 (A β1–28) in patients with mild cognitive impairment (MCI). Thirty-six patients with MCI were selected based on the internationally recognized Petersen’s criteria

and equally and randomly assigned to two groups. The treated group was treated with WYG and the control group was treated with placebo for 3 months. In addition

20 healthy subjects were included in the study as the normal control group. Changes of memory function

SOD activity

MDA content

leukocyte mtDNA deletion rate and A β1–28 content were observed before and after treatment. Compared with the normal control group

the memory quotient and SOD activity in patients with MCI decreased significantly (P < 0.01)

while MDA

A β1–28 levels and the leukocyte mtDNA deletion rate increased significantly (P < 0.01). After treatment

levels of memory quotient and serum SOD activity increased while the serum MDA level

leukocyte mtDNA deletion rate and A β1–28 level decreased in the treated group compared with those before treatment (P<0.01

P<0.05). Meanwhile

leukocyte mtDNA deletion rate and A β1–28 content in the treated group were all lower than those in the control group (P<0.05). WYG could improve memory function in patients with MCI and the therapeutic mechanism is possibly related to the increased activity of anti-oxidase

the improved free radical metabolism and the alleviation of leukocyte mtDNA oxidation damage. WYG shows clinical significance in delaying the progression of MCI.

Abstract

To observe the effects of modified Wuzi Yanzong Granule (加味五子衍宗颗粒

WYG) on memory function and the activity of serum superoxide dismutase (SOD)

malondialdehyde (MDA) levels

and equally and randomly assigned to two groups. The treated group was treated with WYG and the control group was treated with placebo for 3 months. In addition

20 healthy subjects were included in the study as the normal control group. Changes of memory function

SOD activity

MDA content

leukocyte mtDNA deletion rate and A β1–28 content were observed before and after treatment. Compared with the normal control group

the memory quotient and SOD activity in patients with MCI decreased significantly (P < 0.01)

while MDA

A β1–28 levels and the leukocyte mtDNA deletion rate increased significantly (P < 0.01). After treatment

levels of memory quotient and serum SOD activity increased while the serum MDA level

leukocyte mtDNA deletion rate and A β1–28 level decreased in the treated group compared with those before treatment (P<0.01

P<0.05). Meanwhile

the improved free radical metabolism and the alleviation of leukocyte mtDNA oxidation damage. WYG shows clinical significance in delaying the progression of MCI.

关键词

modified Wuzi Yanzong Granulemild cognitive impairmentmemory functionoxidative damageβ- amyloid protein

Keywords

modified Wuzi Yanzong Granulemild cognitive impairmentmemory functionoxidative damageβ- amyloid protein

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