Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus

Fu-rong Lu; Lin Shen; You Qin; Lan Gao; Heng Li; Yi Dai

doi:10.1007/s11655-007-9005-3

Your Location：

Home >

Browse articles >

Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus

Updated：2021-08-27

- Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus
- Chinese Journal of Integrative Medicine Vol. 14, Issue 1, Pages: 56-60(2008)
- Affiliations：
  
  Department of Integrated Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-007-9005-3
  CLC：
- Published：2008，
  
  Published Online：21 June 2008，
Scan for full text
Lu, Fr., Shen, L., Qin, Y. et al. Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus., Chin. J. Integr. Med. 14, 56–60 (2008). https://doi.org/10.1007/s11655-007-9005-3

Fu-rong Lu, Lin Shen, You Qin, et al. Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus. [J]. Chinese Journal of Integrative Medicine 14(1):56-60(2008)
Lu, Fr., Shen, L., Qin, Y. et al. Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus., Chin. J. Integr. Med. 14, 56–60 (2008). https://doi.org/10.1007/s11655-007-9005-3 DOI：

Fu-rong Lu, Lin Shen, You Qin, et al. Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus. [J]. Chinese Journal of Integrative Medicine 14(1):56-60(2008) DOI： 10.1007/s11655-007-9005-3.

摘要

To evaluate the efficacy and safety of trigonella foenum-graecum L. total saponins (TFGs) in combination with sulfonylureas (SU) in the treatment of patients with type 2 diabetes mellitus (T2DM) not well controlled by SU alone. Sixty-nine T2DM patients whose blood glucose levels were not well controlled by oral sulfonylureas hypoglycemic drug were randomly assigned to the treated group (46 cases) and the control group (23 cases)

and were given TFGs or placebo three times per day

6 pills each time for 12 weeks

respectively. Meanwhile

the patients continued taking their original hypoglycemic drugs. The following indexes

including effects on traditional Chinese medicine (TCM) symptoms

fast blood glucose (FBG)

2-h post-prandial blood glucose (2h PBG)

glycosylated hemoglobin (HbA1c)

clinical symptomatic quantitative scores (CSQS)

body mass index (BMI)

as well as hepatic and renal functions

were observed and compared before and after treatment. The efficacy on TCM symptoms was obviously better in the treated group than that in the control group (P<0.01)

and there were statistically remarkable decreases in aspect of FBG

2h PBG

HbA1c and CSQS in the treated group as compared to those in the control group (P<0.05 or P<0.01)

while no signifiClassifi cationcant difference was found in BMI

hepatic and renal functions between the two groups (P>0.05). The combined therapy of TFGs with sulfonylureas hypoglycemic drug could lower the blood glucose level and ameliorate clinical symptoms in the treatment of T2DM

and the therapy was relatively safe.

Abstract

and were given TFGs or placebo three times per day

6 pills each time for 12 weeks

respectively. Meanwhile

the patients continued taking their original hypoglycemic drugs. The following indexes

including effects on traditional Chinese medicine (TCM) symptoms

fast blood glucose (FBG)

2-h post-prandial blood glucose (2h PBG)

glycosylated hemoglobin (HbA1c)

clinical symptomatic quantitative scores (CSQS)

body mass index (BMI)

as well as hepatic and renal functions

were observed and compared before and after treatment. The efficacy on TCM symptoms was obviously better in the treated group than that in the control group (P<0.01)

and there were statistically remarkable decreases in aspect of FBG

2h PBG

HbA1c and CSQS in the treated group as compared to those in the control group (P<0.05 or P<0.01)

while no signifiClassifi cationcant difference was found in BMI

and the therapy was relatively safe.

关键词

trigonella foenum-graecum L.type 2 diabetes mellitussulfonylureas

Keywords

trigonella foenum-graecum L.type 2 diabetes mellitussulfonylureas

references

Pan CY, Jin WS. Epidemiology of type 2 diabetes mellitus. Chin J Endocrinol Metab (Chin) 2005;21(5):5S1–5S5.

Xu MY, Lu GH, Chen MD, eds. Diabetes. Shanghai: Shanghai Scientific and Technical Publishers, 2003:304–305.

Neeraja A, Rajyalakshmi P. Hypoglycemic effect of processed fenugreek seed in humans. J Food Sci Technol 1996;33:427–431.

The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997;20:1057–1058.

The Special Committee of Diabetes Mellitus, Chinese Association of the Integration of Traditional and Western Medicine. Standard for Diagnosis and Therapeutic Effect Evaluation of Diabetes Mellitus by Integrative Chinese and Western Medicine (Draft, Chin). Chin J Integr Med 2005;25(1):94–95.

Ministry of Health, P. R. China. Guiding Principle of Clinical Research on New Drugs of TCM. Vol 1. Beijing: People’s Medical Publishing House, 1993:215–217.

Ferrannini E. Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: problems and prospects. Endocr Rev 1998;19:477–490.

Sharma RD, Sarkar A, Hazra DK, et al. Use of fenugreek seed powder in the management of non-insulin dependent diabetes mellitus. Nutrit Res 1996;16:1331–1339.

Li LL, Zhang YM, Wang XF, et al. The study of TFGs extracts on type 2 diabetes mellitus mice and rats. J Xinjiang Med Univ (Chin) 2005;28(2):98–101.

Ravtkumar P, Anuradha CV. Effect of fenugreek seeds on blood lipid peroxidation and antioxidants in diabetic rats. Phytother Res 1999;13(3):197–201.

Preet A, Siddiqui MR, Taha A, et al. Long-term effect of Trigonella foenum graecum and its combination with sodium orthovanadate in preventing histopathological and biothemical abnormalities in diabetic rat ocular tissues. Mol Cell Biochem 2006;289:137–147.

Thakran S, Siddiqui MR, Baquer NZ. Trigonella foenum graecum seed powder protects against pathological abnormalities in tissues of diabetic rats. Mol Cell Biochem 2004;266:151–159.

Vijayakumar MV, Singh S, Chhipa RR. The hypoglycaemic activity of fenugreek seed extract is mediated through the stimulation of an insulin signalling pathway. Br J Pharmacol 2005;146:41–48.

FULL TEXT LINK

More>

Views

347

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

A systematic review and meta-analysis of type 2 diabetes mellitus treatment based on the “three-typed syndrome differentiation” theory in Chinese medicine

Influence of high blood glucose fluctuation on endothelial function of type 2 diabetes mellitus rats and effects of Panax Quinquefolius Saponin of stem and leaf

Moxibustion for managing type 2 diabetes mellitus: A systematic review

Red ginseng for type 2 diabetes mellitus: A systematic review of randomized controlled trials

Tai chi for management of type 2 diabetes mellitus: A systematic review

Related Author

No data

Related Institution

Guang’anmen Hospital, China Academy of Chinese Medical Sciences

Departmten of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Science

Division of Clinical Medicine, School of Korean Medicine, Pusan National University, Yangsan, South Korea

Brain Disease Research Centre, Korea Institute of Oriental Medicine, Daejeon, South Korea

Acupuncture, Moxibustion and Meridian Research Center, Korea Institute of Oriental Medicine, Daejeon, South Korea

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰