Cardioprotection of Shenfu Injection (参附注射液) against myocardial ischemia/reperfusion injury in open heart surgery

Chuan-dong Zheng; Su Min

doi:10.1007/s11655-008-0010-y

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Cardioprotection of Shenfu Injection (参附注射液) against myocardial ischemia/reperfusion injury in open heart surgery

Updated：2021-08-27

- Cardioprotection of Shenfu Injection (参附注射液) against myocardial ischemia/reperfusion injury in open heart surgery
- Chinese Journal of Integrative Medicine Vol. 14, Issue 1, Pages: 10-16(2008)
- Affiliations：
  
  1. Department of Anesthesiology, Sun Yat-sen University Tungwah Hospital,Dongguan,China
  2. Department of Anesthesiology, The First Affiliated Hospital, Chongqing University of Medical Sciences,Chongqing,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-008-0010-y
  CLC：
- Published：2008，
  
  Published Online：21 June 2008，
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Zheng, Cd., Min, S. Cardioprotection of Shenfu Injection (参附注射液) against myocardial ischemia/reperfusion injury in open heart surgery., Chin. J. Integr. Med. 14, 10–16 (2008). https://doi.org/10.1007/s11655-008-0010-y

Chuan-dong Zheng, Su Min. Cardioprotection of Shenfu Injection (参附注射液) against myocardial ischemia/reperfusion injury in open heart surgery. [J]. Chinese Journal of Integrative Medicine 14(1):10-16(2008)
Zheng, Cd., Min, S. Cardioprotection of Shenfu Injection (参附注射液) against myocardial ischemia/reperfusion injury in open heart surgery., Chin. J. Integr. Med. 14, 10–16 (2008). https://doi.org/10.1007/s11655-008-0010-y DOI：

Chuan-dong Zheng, Su Min. Cardioprotection of Shenfu Injection (参附注射液) against myocardial ischemia/reperfusion injury in open heart surgery. [J]. Chinese Journal of Integrative Medicine 14(1):10-16(2008) DOI： 10.1007/s11655-008-0010-y.

摘要

To investigate the protective effect of Shenfu Injection (参附注射液

SFI) against myocardium ischemia/reperfusion injury (IRI) in mitral valve replacement (MVR) with cardiopulmonary bypass (CPB). Forty patients undergoing selective MVR were randomly assigned to the control group and trial Groups I

III

and IV according to the different administrations of SFI

8 patients in each group. The changes of systolic blood pressure (SBP)

mean blood pressure (MBP)

diastolic blood pressure (DBP) in each group were monitored

respectively. The recovering percentage of spontaneous heart beat

the heart rate (HR) and cardiac rhythm as well as the abnormal duration of ECG-ST segment were recorded after the restoration of heart beat. The serum concentration of cardiac troponin I (cTnI)

malondialdehyde (MDA) and the activity of superoxide dismutase (SOD) were determined as well. (1) The SBP

MBP and DBP values

the recovering rate of spontaneous heart beat

ECG-ST

atrioventricular block and ventricular arrhythmia were significantly improved in group IV compared with any other groups. (2) Compared with the control group

the postoperative serum contents of cTnI and MDA were significantly decreased

but the activity of SOD was significantly increased in group IV. SFI had a certain protective effect against myocardium IRI. Moreover

better efficacy was seen with the administration of 1.5 mL/kg SFI into CPB priming fluid and pumping 1.5 mL/kg SFI via CPB as soon as the clamped aorta was unclamped.

Abstract

To investigate the protective effect of Shenfu Injection (参附注射液

III

and IV according to the different administrations of SFI

8 patients in each group. The changes of systolic blood pressure (SBP)

mean blood pressure (MBP)

diastolic blood pressure (DBP) in each group were monitored

respectively. The recovering percentage of spontaneous heart beat

the heart rate (HR) and cardiac rhythm as well as the abnormal duration of ECG-ST segment were recorded after the restoration of heart beat. The serum concentration of cardiac troponin I (cTnI)

malondialdehyde (MDA) and the activity of superoxide dismutase (SOD) were determined as well. (1) The SBP

MBP and DBP values

the recovering rate of spontaneous heart beat

ECG-ST

atrioventricular block and ventricular arrhythmia were significantly improved in group IV compared with any other groups. (2) Compared with the control group

the postoperative serum contents of cTnI and MDA were significantly decreased

but the activity of SOD was significantly increased in group IV. SFI had a certain protective effect against myocardium IRI. Moreover

better efficacy was seen with the administration of 1.5 mL/kg SFI into CPB priming fluid and pumping 1.5 mL/kg SFI via CPB as soon as the clamped aorta was unclamped.

关键词

Shenfu Injectioncardiopulmonary bypassmitral valve replacementmyocardial protectionischemia/reperfusion injury

Keywords

Shenfu Injectioncardiopulmonary bypassmitral valve replacementmyocardial protectionischemia/reperfusion injury

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