Effect of volatile oil of amomum on expressions of platelet activating factor and mastocarcinoma-related peptide in the gastric membrane of chronic gastritis patients with helicobacter-pylori infection

Guo-dong Huang; Yuan-hua Huang; Mei-zhen Xiao; Dao-fu Huang; Juan Liu; Jia-bang Li

doi:10.1007/s11655-008-0023-6

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Effect of volatile oil of amomum on expressions of platelet activating factor and mastocarcinoma-related peptide in the gastric membrane of chronic gastritis patients with helicobacter-pylori infection

Updated：2021-08-27

- Effect of volatile oil of amomum on expressions of platelet activating factor and mastocarcinoma-related peptide in the gastric membrane of chronic gastritis patients with helicobacter-pylori infection
- Chinese Journal of Integrative Medicine Vol. 14, Issue 1, Pages: 23-27(2008)
- Affiliations：
  
  1. Department of Integrative Medicine, the First Affiliated Hospital of Nanchang University, Nangchang,China
  2. Hengyang Hospital, Hunan University of Chinese Medicine,Hunan,China
  3. Changsha Medical College,Changsha,China
  4. Xiangya Hospital of Central South University,Changsha,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-008-0023-6
  CLC：
- Published：2008，
  
  Published Online：21 June 2008，
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Huang, Gd., Huang, Yh., Xiao, Mz. et al. Effect of volatile oil of amomum on expressions of platelet activating factor and mastocarcinoma-related peptide in the gastric membrane of chronic gastritis patients with helicobacter-pylori infection., Chin. J. Integr. Med. 14, 23–27 (2008). https://doi.org/10.1007/s11655-008-0023-6

Guo-dong Huang, Yuan-hua Huang, Mei-zhen Xiao, et al. Effect of volatile oil of amomum on expressions of platelet activating factor and mastocarcinoma-related peptide in the gastric membrane of chronic gastritis patients with helicobacter-pylori infection. [J]. Chinese Journal of Integrative Medicine 14(1):23-27(2008)
Huang, Gd., Huang, Yh., Xiao, Mz. et al. Effect of volatile oil of amomum on expressions of platelet activating factor and mastocarcinoma-related peptide in the gastric membrane of chronic gastritis patients with helicobacter-pylori infection., Chin. J. Integr. Med. 14, 23–27 (2008). https://doi.org/10.1007/s11655-008-0023-6 DOI：

Guo-dong Huang, Yuan-hua Huang, Mei-zhen Xiao, et al. Effect of volatile oil of amomum on expressions of platelet activating factor and mastocarcinoma-related peptide in the gastric membrane of chronic gastritis patients with helicobacter-pylori infection. [J]. Chinese Journal of Integrative Medicine 14(1):23-27(2008) DOI： 10.1007/s11655-008-0023-6.

摘要

To observe the effect of volatile oil of amomum (VOA) on the expressions of mastocarcinoma-related peptide (PS2) and platelet activating factor (PAF) in helicobacter pyloriassociated gastritis (HPG) and to analyze its potential mechanism. Eighty patients with HPG were randomly assigned to two groups

42 patients in the treated group treated with 0.5 mL VOA

thrice per day; and the 38 patients in the control group receiving Western tertiary medicinal treatment. Gastroscopic picture and helicobacter pylori (HP) infection (by quick urease and Warthin-Starry stain) of the gastro-membrane

expressions of PS2 and PAF (by immunohistochemical assay and Western blotting) as well as the contents of aminohexose and phospholipid (by Neuhaus method) in the gastric membrane of all patients were detected before treatment and 4 weeks after treatment. The clinical effi cacy in the two groups was compared. The total effective rate in the treated group was 88.1%

which was significantly higher than that in the control group (78.9%

P<0.05). After treatment

in the treated group

gastric membranous contents of aminohexose and phospholipid was increased

expression of PS2 elevated but that of PAF lowered

all showing significant difference as compared with those in the control group (P<0.01). In the control group

the expressions of PS2 and PAF changed insignificantly. The radical eliminating rate of HP in the treated group and the control group was insignificantly different between them (76.1% vs. 65.8%

P>0.05). The mechanism of VOA for anti-gastritis might be related with its action in increasing the expression of PS2 and decreasing the expression of PAF

and thus regulating the hydrophobicity of the gastric membrane.

Abstract

42 patients in the treated group treated with 0.5 mL VOA

which was significantly higher than that in the control group (78.9%

P<0.05). After treatment

in the treated group

gastric membranous contents of aminohexose and phospholipid was increased

expression of PS2 elevated but that of PAF lowered

all showing significant difference as compared with those in the control group (P<0.01). In the control group

the expressions of PS2 and PAF changed insignificantly. The radical eliminating rate of HP in the treated group and the control group was insignificantly different between them (76.1% vs. 65.8%

P>0.05). The mechanism of VOA for anti-gastritis might be related with its action in increasing the expression of PS2 and decreasing the expression of PAF

and thus regulating the hydrophobicity of the gastric membrane.

关键词

Helicobacter pyloriGastritisplatelet activating factor mastocarcinoma-related peptidevolatile oil of amomum

Keywords

Helicobacter pyloriGastritisplatelet activating factor mastocarcinoma-related peptidevolatile oil of amomum

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Department of Gastroenterology, Peking University First Hospital

Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine

Department of Tradional Chinese Medicine and Integrated Tradional Chinese and Western Medicine, Peking University First Hospital

Health Science Centre of Peking University

The Third Hospital of Peking University

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