To observe the effect of Lidan Granule (利胆冲剂

LDG) on bile lithogenic tendency and biliary 33.5 kd vesicular protein (VP) and to explore its mechanism. Sixty patients with choledocholithiasis combined with cholecystolithiasis were randomly assigned to the LDG treated group

the sodium cholate treated group for positive control

and the untreated control group

20 patients in each group. The 4 bile lithogenic trend indexes

including lithogenic index (LI)

unconjugated bilirubin percent (UCB%)

unconjugated bilirubin saturation index (BSI) and Z-value

were determined before and after treatment. The content of VP in bile was determined as well. Before treatment

the LI

UCB%

BSI and Z-value in the LDG treated group were 1.298± 0.265

34.72±2.96

0.353±0.093 and 0.556±0.499

respectively

which was decreased after the 2-week treatment to 0.926±0.208

8.93±1.19

0.154±0.056 and 0.257±0.211

respectively (all P<0.05). Meantime

the content of VP was also lowered from 0.050±0.005 g/L to 0.032±0.005 g/L. However

no signifi cant change in any of the above-mentioned indexes was found in the other two groups. LDG could effectively suppress bile lithogenic trend and reduce 33.5 kd VP in bile.