FOLLOWUS
Application of kushenin on patients with chronic hepatitis C after renal transplantation
- Chinese Journal of Integrative Medicine Vol. 14, Issue 3, Pages: 167-172(2008)
- Affiliations：
1. Department of Renal Transplant, Center of Nephropathy, Medical College, Xi’an Jiaotong University,Xi’an,China
2. Department of Rheumatism, The First Affiliated Hospital, Medical College, Xi’an Jiaotong University,Xi’an,China
- Author bio：
- Funds：Supportted by National Natural Science Foundation of China (No. 30571799, 30471640)
DOI：10.1007/s11655-008-0167-4
CLC：Published：2008，
Published Online：14 October 2008，
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Li, Y., Xue, Wj., Fan, P. et al. Application of kushenin on patients with chronic hepatitis C after renal transplantation., Chin. J. Integr. Med. 14, 167 (2008). https://doi.org/10.1007/s11655-008-0167-4
Yang Li, Wu-jun Xue, Ping Fan, et al. Application of kushenin on patients with chronic hepatitis C after renal transplantation. [J]. Chinese Journal of Integrative Medicine 14(3):167-172(2008)
Li, Y., Xue, Wj., Fan, P. et al. Application of kushenin on patients with chronic hepatitis C after renal transplantation., Chin. J. Integr. Med. 14, 167 (2008). https://doi.org/10.1007/s11655-008-0167-4 DOI：
Yang Li, Wu-jun Xue, Ping Fan, et al. Application of kushenin on patients with chronic hepatitis C after renal transplantation. [J]. Chinese Journal of Integrative Medicine 14(3):167-172(2008) DOI： 10.1007/s11655-008-0167-4.
摘要
To evaluate the efficacy of kushenin in treating patients with chronic hepatitis C after renal transplantation. Fifty-five patients were randomly assigned by lottery to the treatment group (29 cases) and control group (26 cases). The same immunosuppression therapy was given to all patients in both groups. Patients in the treatment group were treated with kushenin 0.6 g once a day
while those in the control group were treated with conventional liver protective agents such as vitamins. The treatment duration of both groups was 3 months. The incidences of serious hepatitis and acute rejection reaction
serum biochemistry parameters including indicators of liver and kidney functions
hepatic fibrosis index
and serum HCV-RNA were compared between the two groups. (1) The incidence of serious hepatitis in the treatment group and the control group was 3.45% (1/29 cases) and 11.54% (3/26 cases)
respectively
which was insignificantly different between the two groups (P=0.335). (2) The incidence of acute rejection in the treatment group was 6.90% (2/29 cases) and that in the control group was 7.69% (2/26 cases)
showing insignificant difference (P=0.335). (3) The differences in serum alanine aminotransferase (ALT)
direct bilirubin (DBIL)
hyaluronic acid (HA)
propeptide collagen type III (PC III)
laminin (LN)
collagen type IV (Col IV) levels between the two groups were insignificant before transplantation (P>0.05)
while the above-mentioned parameters in the treatment group were significantly lower than those in the control group after transplantation (P<0.05). The difference in serum creatinine (SCr) and endogenous creatinine clearance rate (CCr) between the two groups was insignificant before and after transplantation (P>0.05). (4) The negative conversion rate of HCV-RNA in the treatment group was 31.03% (9/29 cases)
significantly higher than the value of 11.54% (3/26 cases) in the control group after transplantation (P<0.05). (5) The levels of serum ALT and DBIL in patients with HCV-RNA converted to negative were significantly lower than those with still-positive HCV-RNA (P<0.05). Kushenin has a certain effect on inhibiting the proliferation of HCV
protecting liver cells
and anti-liver fibrosis. On the other hand
it has no obvious influence on renal allograft function. Thus
the drug is clinically safe and effective for use in treating patients with chronic hepatitis C after renal transplantation.
Abstract
To evaluate the efficacy of kushenin in treating patients with chronic hepatitis C after renal transplantation. Fifty-five patients were randomly assigned by lottery to the treatment group (29 cases) and control group (26 cases). The same immunosuppression therapy was given to all patients in both groups. Patients in the treatment group were treated with kushenin 0.6 g once a day
while those in the control group were treated with conventional liver protective agents such as vitamins. The treatment duration of both groups was 3 months. The incidences of serious hepatitis and acute rejection reaction
serum biochemistry parameters including indicators of liver and kidney functions
hepatic fibrosis index
and serum HCV-RNA were compared between the two groups. (1) The incidence of serious hepatitis in the treatment group and the control group was 3.45% (1/29 cases) and 11.54% (3/26 cases)
respectively
which was insignificantly different between the two groups (P=0.335). (2) The incidence of acute rejection in the treatment group was 6.90% (2/29 cases) and that in the control group was 7.69% (2/26 cases)
showing insignificant difference (P=0.335). (3) The differences in serum alanine aminotransferase (ALT)
direct bilirubin (DBIL)
hyaluronic acid (HA)
propeptide collagen type III (PC III)
laminin (LN)
collagen type IV (Col IV) levels between the two groups were insignificant before transplantation (P>0.05)
while the above-mentioned parameters in the treatment group were significantly lower than those in the control group after transplantation (P<0.05). The difference in serum creatinine (SCr) and endogenous creatinine clearance rate (CCr) between the two groups was insignificant before and after transplantation (P>0.05). (4) The negative conversion rate of HCV-RNA in the treatment group was 31.03% (9/29 cases)
significantly higher than the value of 11.54% (3/26 cases) in the control group after transplantation (P<0.05). (5) The levels of serum ALT and DBIL in patients with HCV-RNA converted to negative were significantly lower than those with still-positive HCV-RNA (P<0.05). Kushenin has a certain effect on inhibiting the proliferation of HCV
protecting liver cells
and anti-liver fibrosis. On the other hand
it has no obvious influence on renal allograft function. Thus
the drug is clinically safe and effective for use in treating patients with chronic hepatitis C after renal transplantation.
关键词
renal transplantationkusheninchronic hepatitis C
Keywords
renal transplantationkusheninchronic hepatitis C
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