Regulatory effect of Langchuang serial recipes on T-lymphocyte subsets Th and Tc in patients with systemic lupus erythematosus

Xiao-juan Tao; Hong-xia Zheng; Jian-ning Yu; Ji-lin Ma; Wen Zhang

doi:10.1007/s11655-008-0180-7

Your Location：

Home >

Browse articles >

Regulatory effect of Langchuang serial recipes on T-lymphocyte subsets Th and Tc in patients with systemic lupus erythematosus

Updated：2021-08-27

- Regulatory effect of Langchuang serial recipes on T-lymphocyte subsets Th and Tc in patients with systemic lupus erythematosus
- Chinese Journal of Integrative Medicine Vol. 14, Issue 3, Pages: 180-184(2008)
- Affiliations：
  
  Department of Rheumatology and Immunology, Hospital of Integrative Chinese and Western Medicine,Hangzhou,China
- Author bio：
- Funds：
  
  Supported by the Funds of Hangzhou Municipal Medical Key Subjects (No. 2005633Q14)
- DOI：10.1007/s11655-008-0180-7
  CLC：
- Published：2008，
  
  Published Online：14 October 2008，
Scan for full text
Tao, Xj., Zheng, Hx., Yu, Jn. et al. Regulatory effect of Langchuang serial recipes on T-lymphocyte subsets Th and Tc in patients with systemic lupus erythematosus., Chin. J. Integr. Med. 14, 180–184 (2008). https://doi.org/10.1007/s11655-008-0180-7

Xiao-juan Tao, Hong-xia Zheng, Jian-ning Yu, et al. Regulatory effect of Langchuang serial recipes on T-lymphocyte subsets Th and Tc in patients with systemic lupus erythematosus. [J]. Chinese Journal of Integrative Medicine 14(3):180-184(2008)
Tao, Xj., Zheng, Hx., Yu, Jn. et al. Regulatory effect of Langchuang serial recipes on T-lymphocyte subsets Th and Tc in patients with systemic lupus erythematosus., Chin. J. Integr. Med. 14, 180–184 (2008). https://doi.org/10.1007/s11655-008-0180-7 DOI：

Xiao-juan Tao, Hong-xia Zheng, Jian-ning Yu, et al. Regulatory effect of Langchuang serial recipes on T-lymphocyte subsets Th and Tc in patients with systemic lupus erythematosus. [J]. Chinese Journal of Integrative Medicine 14(3):180-184(2008) DOI： 10.1007/s11655-008-0180-7.

摘要

To study the principle of clearing Fei (肺)

cooling blood

and detoxification as well as nourishing yin and moisening Fei (abbr. as CCD-NM) in regulating the levels of peripheral T-lymphocyte subsets Th and Tc cells to explore its mechanism for lowering the incidence of infection in patients with systemic lupus erythematosus (SLE). Sixty SLE patients without complicated infection were assigned to the treatment group and the control group

30 in each group. The control group was treated with Western medicine alone

while the treatment group was treated with the same program of Western medicine

but additionally administered with either Langchuang No.1 (狼疮I号) or 2 (狼疮II号)

serial concerted Chinese recipes

applied respectively in patients in the active stage or in the resting stage. The total time of treatment for both groups was 1 year. Further

a healthy control group was set up with 20 healthy subjects. The expressions of Th1

Th2

and Tc1 and Tc2 cells in peripheral blood were detected and compared with those in the healthy control group. (1) As compared with the healthy control group

ratios of Th1/Th2 and Tc1/Tc2 in SLE patients

whether complicated with infection or not

were significantly lower (P<0.05 or P<0.01). (2) Comparison between patients with complications and those uncomplicated with infection showed that the two ratios and Th1 expression were lower and Tc2 was higher in the former than those in the latter (all P<0.05). (3) Ratios of Th1/Th2 and Tc1/Tc2 increased after treatment in patients of both the treatment group and the control group (P<0.05 and P<0.01)

but the changes in the treatment group were more significant (P<0.05). The principle of CCD-NM could regulate the Th and Tc subsets toward equilibrium in SLE patients

which might be one of the mechanisms of action for alleviating complicated infection.

Abstract

To study the principle of clearing Fei (肺)

cooling blood

30 in each group. The control group was treated with Western medicine alone

while the treatment group was treated with the same program of Western medicine

but additionally administered with either Langchuang No.1 (狼疮I号) or 2 (狼疮II号)

serial concerted Chinese recipes

applied respectively in patients in the active stage or in the resting stage. The total time of treatment for both groups was 1 year. Further

a healthy control group was set up with 20 healthy subjects. The expressions of Th1

Th2

and Tc1 and Tc2 cells in peripheral blood were detected and compared with those in the healthy control group. (1) As compared with the healthy control group

ratios of Th1/Th2 and Tc1/Tc2 in SLE patients

whether complicated with infection or not

but the changes in the treatment group were more significant (P<0.05). The principle of CCD-NM could regulate the Th and Tc subsets toward equilibrium in SLE patients

which might be one of the mechanisms of action for alleviating complicated infection.

关键词

Langchuang No.1Langchuang No.2systemic lupus erythematosusinfectionTh and Tc subsets of T-lymphocyte

Keywords

Langchuang No.1Langchuang No.2systemic lupus erythematosusinfectionTh and Tc subsets of T-lymphocyte

references

Cervera R, Khamashta MA, Font J, et al. Morbidity and mortality in systemic lupus erythematosus during a 1. 5-year period. A multicenter prospective study of 1000 patients. European Working Party on Systemic Lupus Erythematosus. Medicine (Baltimore) 1999;78:167–175.

Mok CC, Lee KW, Ho CT, et al. A prospective study of survival and prognostic indicators of systemic lupus erythematosus in a southern Chinese population. Rheumatology (Oxford) 2000;39(4):399–406.

Tao XJ, Zheng HX, Yu JN, et al. Clinical research on effect of TCM treatment beginning with Fei in treating systemic lupus erythematosus for reducing incidence of complicated infection. Chin J Integr Tradit West Med (Chin) 2007;27(1):33–36.

Tan EM, Cohen AS, Fries JF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus (SLE). Arthritis Rheum 1982;25:1271–1277.

Hay E, Cordon C, Emery P, et al. Assessment of lupus. Where are we now? Ann Rheum Dis 1993;52:169–172.

Varadhachary AS, Peter ME, Perdow SN, et al. Seletive up-regulation of phosphatidylinositol 3′-kinase activity in Th2 cells inhibits caspase-8 cleavage at the death-inducing complex: a mechanism for Th2 resistance from Fasmediated apoptosis. J Immunol 1999;163:4772–4779.

Li ZJ, Wang CL, Fan XY, et al. Clinical study on the patients with systemic lupus erythematosus complicated by infections. Chin J Rheumatol (Chin) 2000;4(3):165–168.

Xu G, Liu ML, Yu KM. A prospective study of nosocomial infection in patients with systemic lupus erythematosus. Chin J Rheumatol (Chin) 2003;7(4):216–219.

Xu G, Xu Q, Yu LM. An analysis of nosocomial infection in patients with systemic lupus erythematosus. Chin J Nosocomiol (Chin) 2000;10(5):362–364.

Yu Y, Chen J, Xie FA, et al. Clinical investigation of nosocomial infection cases with lupus nephritis. Chin J Nosocomiol (Chin) 2000;10(3):174–176.

FULL TEXT LINK

More>

Views

392

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Effect of Xuebijing injection (血必净注射液) on systemic lupus erythematosus in mice

Systemic lupus erythematosus complicated with femoral head ischemic necrosis treated by Chinese medicine therapy for activating blood and dredging collaterals method

Effect of detoxification, removing stasis and nourishing yin method on corticosteroid-induced hyperlipidemia in patients with systemic lupus rythematosus

Study of the effect of leeching on plasma endothelin and soluble interleukin-2 receptor in patients with systemic lupus erythematosus

Effects of langchuangjing granule on apoptotic of CD4 + T and CD19 + B in spleen of BXSB mice with systemic lupus erythematosus

Related Author

No data

Related Institution

Burns Institute, First Hospital Affiliated to the Chinese PLA General Hospital

Chinese Center for Disease Control and Prevention

Department of Dermatology, Xijing Hospital, Fourth Military Medical University

Departement of Rheumatology, Immunology and Nephropathy, Zhejiang Provincial Hospital of Integrated Chinese and Western Medicine, Hanghzhou

The First Affiliated Hospital, Zhejiang Traditional Chinese Medicine University

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰