Effect of sodium tanshinone II A sulfonate on cardiac myocyte hypertrophy and its underlying mechanism

Jun Feng; Zhi Zheng

doi:10.1007/s11655-008-0197-y

Your Location：

Home >

Browse articles >

Effect of sodium tanshinone II A sulfonate on cardiac myocyte hypertrophy and its underlying mechanism

Updated：2021-08-27

- Effect of sodium tanshinone II A sulfonate on cardiac myocyte hypertrophy and its underlying mechanism
- Chinese Journal of Integrative Medicine Vol. 14, Issue 3, Pages: 197-201(2008)
- Affiliations：
  
  Department of Emergency Internal Medicine, Tongji Hospital, Huazhong University of Science and Technology,Wuhan,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 30500657)
- DOI：10.1007/s11655-008-0197-y
  CLC：
- Published：2008，
  
  Published Online：14 October 2008，
Scan for full text
Feng, J., Zheng, Z. Effect of sodium tanshinone II A sulfonate on cardiac myocyte hypertrophy and its underlying mechanism., Chin. J. Integr. Med. 14, 197–201 (2008). https://doi.org/10.1007/s11655-008-0197-y

Jun Feng, Zhi Zheng. Effect of sodium tanshinone II A sulfonate on cardiac myocyte hypertrophy and its underlying mechanism. [J]. Chinese Journal of Integrative Medicine 14(3):197-201(2008)
Feng, J., Zheng, Z. Effect of sodium tanshinone II A sulfonate on cardiac myocyte hypertrophy and its underlying mechanism., Chin. J. Integr. Med. 14, 197–201 (2008). https://doi.org/10.1007/s11655-008-0197-y DOI：

Jun Feng, Zhi Zheng. Effect of sodium tanshinone II A sulfonate on cardiac myocyte hypertrophy and its underlying mechanism. [J]. Chinese Journal of Integrative Medicine 14(3):197-201(2008) DOI： 10.1007/s11655-008-0197-y.

摘要

To investigate the effects of sodium tanshinone II A sulfonate (STS) on the hypertrophy induced by angiotensin II (Ang II) in primary cultured neonatal rat cardiac myocytes. The effect of STS on cytotoxicity was evaluated using the 3-(4

5-dimethylthiazol-2-yl)-3

5-phenytetrazoliumromide (MTT) assay. As indexes for cardiocyte hypertrophy

cell size was determined by phase contrast microscopy and protein synthesis rate was measured by 3H-leucine incorporation. The proto-oncogene c-fos mRNA expression of cardiocytes was assessed using reverse transcription polymerase chain reaction (RT-PCR). STS could inhibit cardiocyte hypertrophy

increase the protein synthesis rate and enhance proto-oncogene c-fos mRNA expression in cardiocytes induced by Ang II (P<0.01)

with an effect similar to that of Valsartan

the Ang II receptor antagonist. STS can prevent the hypertrophy of cardiac myocytes induced by Ang II

which may be related to its inhibition of the expression of proto-oncogene c-fos mRNA.

Abstract

5-dimethylthiazol-2-yl)-3

5-phenytetrazoliumromide (MTT) assay. As indexes for cardiocyte hypertrophy

increase the protein synthesis rate and enhance proto-oncogene c-fos mRNA expression in cardiocytes induced by Ang II (P<0.01)

with an effect similar to that of Valsartan

the Ang II receptor antagonist. STS can prevent the hypertrophy of cardiac myocytes induced by Ang II

which may be related to its inhibition of the expression of proto-oncogene c-fos mRNA.

关键词

sodium tanshinone II A sulfonateangiotensin IIcardiac myocyte hypertrophyc-fos

Keywords

sodium tanshinone II A sulfonateangiotensin IIcardiac myocyte hypertrophyc-fos

references

Messerli FH, Ketelhut R. Left ventricular hypertrophy: a pressure-independent cardiovascular risk factor. J Cardiovasc Pharmacol 1993; 22(suppl 1):s7–s13.

Sadoshima J, Izumo S. Molecular characterization of angiotensin II-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype. Cre Res 1993;73:413–423.

Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65:55–63.

Yang K, Mu XS, Xue JJ, et al. Increased expression of c-fos mRNA and AP-1 transcription factors after cortical impact injury in rat. Brain Res 1994;664:141–147.

Tang W, Eisenbrand G. Salvia militiorrhiza Bge. Chinese drugs of plant origin. Berlin: Spring-Verlag, Germany, 1992:891–902.

Shanghai Cooperative Group for the study of tanshinone II A. Therapeutic effect of tanshinone II A sulfonate in patients with coronary heart disease: a double blind study. J Tradit Chin Med 1984;4(1);20–24.

Hefti MA, Hander BA, Eppenberger HM, et al. Signaling of pathways in cardiac myocyte hypertrophy. J Mol Cell Cardiol 1997;29:2873–2892.

Sadoshima J, Izumo S. Signal transduction pathways of angiotensin II-induced c-fos gene expression in cardiac myocytes in vitro. Roles of phospholipid-derived second messengers. Circ Res 1993;73:424–438.

Ballard C, Schaffer S. Stimulation of the Na+/Ca2+ exchanger by phenylephrine, angiotensin II and endothelin 1. J Mol Cell Cardiol 1996;28:11–17.

Chien KR, Knowlton KU, Zhu H, et al. Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response. FASEB J 1991; 5:3037–3046.

Liu QY, Tsai TD. Effects of sodium tanshinone II-A sulfonate on slow action potentials of dissociated single ventricular cells of adult guinea pig heart. Acta Physiol Sin 1990;42(3):254–261.

Li F, Wang XM, Li XZ, et al. A time-related study about morphometry in myocardial ultrastructure and Ca distribution in ischemia and reperfusion damage and the protective effect of Danshen for the heart. Chin J Pathophysiol (Chin) 1992; 8(6): 565–568.

Xu CQ, Fan JS, Hao XM, et al. Blocking effect of tanshinone II-A on L-type Ca2+ current of single ventricular myocyte from guinea pig. Chin J Pharmacol Toxical (Chin) 1996; 10(2): 81–84.

FULL TEXT LINK

More>

Views

386

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Effect of sodium tanshinone II A sulfonate on phosphorylation of extracellular signal-regulated kinase 1/2 in angiotensin II-induced hypertrophy of myocardial cells

Time-effect relationship of extracts from ginseng, notoginseng and chuanxiong on vascular endothelial cells senescence

Effects of Qindan Capsule (芩丹胶囊) on blood pressure, endothelin, calcitonin gene-related peptide and angiotensin-II in spontaneous hypertensive rats

Effects of serum containing Xinlikang on angiotensin II induced hypertrophy in cultured neonatal rat cardiomyocytes

Related Author

No data

Related Institution

Key Laboratory of Basic Pharmacology of Guizhou and Department of Pharmacology, Zunyi Medical College

Department of Hematology, the Affiliated Hospital of Guiyang Medical College

The Cardiology Department of Chongqing Hospital of Traditional Chinese Medicine and Chongqing the First Hospital

The Experimental Research Center, China Academy of Chinese Medical Sciences

Department of TCM, Qilu Hospital Affiliated to Shandong University

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰