Effect of Qiangxin Fumai Granule (强心复脉颗粒) on electrophysiological functions of the sinoatrial node during ischemia-reperfusion of the right coronary artery in rabbits

Ru-xiu Liu; Shuang Tan; Zhi-ming Liu; Jie Wang; Yan-yun Wang

doi:10.1007/s11655-008-0202-5

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Effect of Qiangxin Fumai Granule (强心复脉颗粒) on electrophysiological functions of the sinoatrial node during ischemia-reperfusion of the right coronary artery in rabbits

Updated：2021-08-27

- Effect of Qiangxin Fumai Granule (强心复脉颗粒) on electrophysiological functions of the sinoatrial node during ischemia-reperfusion of the right coronary artery in rabbits
- Chinese Journal of Integrative Medicine Vol. 14, Issue 3, Pages: 202-206(2008)
- Affiliations：
  
  1. Department of Cardiology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences,Beijing,China
  2. Centre of Chinese Medicine Research and Development, Guang’anmen Hospital, China Academy of Chinese Medical Sciences,Beijing,China
- Author bio：
- Funds：
  
  Supported by the Funds of State Administration of Traditional Chinese Medicine (No. 04-05JP61)
- DOI：10.1007/s11655-008-0202-5
  CLC：
- Published：2008，
  
  Published Online：14 October 2008，
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Liu, Rx., Tan, S., Liu, Zm. et al. Effect of Qiangxin Fumai Granule (强心复脉颗粒) on electrophysiological functions of the sinoatrial node during ischemia-reperfusion of the right coronary artery in rabbits., Chin. J. Integr. Med. 14, 202–206 (2008). https://doi.org/10.1007/s11655-008-0202-5

Ru-xiu Liu, Shuang Tan, Zhi-ming Liu, et al. Effect of Qiangxin Fumai Granule (强心复脉颗粒) on electrophysiological functions of the sinoatrial node during ischemia-reperfusion of the right coronary artery in rabbits. [J]. Chinese Journal of Integrative Medicine 14(3):202-206(2008)
Liu, Rx., Tan, S., Liu, Zm. et al. Effect of Qiangxin Fumai Granule (强心复脉颗粒) on electrophysiological functions of the sinoatrial node during ischemia-reperfusion of the right coronary artery in rabbits., Chin. J. Integr. Med. 14, 202–206 (2008). https://doi.org/10.1007/s11655-008-0202-5 DOI：

Ru-xiu Liu, Shuang Tan, Zhi-ming Liu, et al. Effect of Qiangxin Fumai Granule (强心复脉颗粒) on electrophysiological functions of the sinoatrial node during ischemia-reperfusion of the right coronary artery in rabbits. [J]. Chinese Journal of Integrative Medicine 14(3):202-206(2008) DOI： 10.1007/s11655-008-0202-5.

摘要

To study the effect of the Chinese medicine Qiangxin Fumai Granule (强心复脉颗粒

QFG) on electrophysiological functions of the sinoatrial node during ischemia-reperfusion (IR) of the right coronary artery in rabbits. The right coronary artery IR model in rabbits was adopted. The modeled rabbits were randomly divided into 4 groups: the model group

the atropine group

the high-dose QFG group

and the low-dose QFG group

with 8 animals in each group. In addition

twelve rabbits were selected for the sham-operative group. The drugs were administered once via duodenal perfusion after modeling had been stabilized for 10 min. The changes in AA interval

the sinoatrial conduction time (SACT)

the sinus node recovery time (SNRT)

the corrected sinus node recovery time (CSNRT) and the index of sinus node recovery time (ISNRT) at different time points during ischemia and reperfusion were measured. The AA interval was prolonged for more than 40 ms in the model group during ischemia. Compared with the model group

the four electrophysiological parameters abovementioned in the high-dose QFG group and the low-dose QFG group were decreased to different extents at each time point (P<0.01 or P<0.05)

and no statistically significant differences were found between the QFG groups and the atropine group (P>0.05). QFG is beneficial for accelerating the recovery of sinus node autorhythmicity and conduction function

so as to protect electrophysiological functions of the sinoatrial node. Accelerating the recovery of autorhythmicity and conduction function in the sinus node is considered its electrophysiological mechanism in the treatment of sinoatrial node injury induced by ischemia.

Abstract

To study the effect of the Chinese medicine Qiangxin Fumai Granule (强心复脉颗粒

the atropine group

the high-dose QFG group

and the low-dose QFG group

with 8 animals in each group. In addition

twelve rabbits were selected for the sham-operative group. The drugs were administered once via duodenal perfusion after modeling had been stabilized for 10 min. The changes in AA interval

the sinoatrial conduction time (SACT)

the sinus node recovery time (SNRT)

the four electrophysiological parameters abovementioned in the high-dose QFG group and the low-dose QFG group were decreased to different extents at each time point (P<0.01 or P<0.05)

关键词

Qiangxin Fumai Granuleischemia-reperfusionsinoatrial node function

Keywords

Qiangxin Fumai Granuleischemia-reperfusionsinoatrial node function

references

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Beijing Institute of Heart, Lung and Vessel Diseases, Beijing Anzhen Hospital, Capital University of Medical Sciences

Department of Province Neurology, Beijing Huimin Hospital

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