Effect of Radix Isatidis polysaccharides on immunological function and expression of immune related cytokines in mice

Yan-ling Zhao; Jia-bo Wang; Li-mei Shan; Cheng Jin; Li Ma; Xiao-he Xiao

doi:10.1007/s11655-008-0207-2

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Effect of Radix Isatidis polysaccharides on immunological function and expression of immune related cytokines in mice

Updated：2021-08-27

- Effect of Radix Isatidis polysaccharides on immunological function and expression of immune related cytokines in mice
- Chinese Journal of Integrative Medicine Vol. 14, Issue 3, Pages: 207-211(2008)
- Affiliations：
  
  Institute of Traditional Chinese Material Medica, the Hospital of PLA,Beijing,China,302
- Author bio：
- Funds：
  
  Supported by Foundation of State Administration of Traditional Chinese Medicine (No. 04-05ZP970) and Military 11th Five-Year Foundation (No. 06MA360)
- DOI：10.1007/s11655-008-0207-2
  CLC：
- Published：2008，
  
  Published Online：14 October 2008，
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Zhao, Yl., Wang, Jb., Shan, Lm. et al. Effect of Radix Isatidis polysaccharides on immunological function and expression of immune related cytokines in mice., Chin. J. Integr. Med. 14, 207–211 (2008). https://doi.org/10.1007/s11655-008-0207-2

Yan-ling Zhao, Jia-bo Wang, Li-mei Shan, et al. Effect of Radix Isatidis polysaccharides on immunological function and expression of immune related cytokines in mice. [J]. Chinese Journal of Integrative Medicine 14(3):207-211(2008)
Zhao, Yl., Wang, Jb., Shan, Lm. et al. Effect of Radix Isatidis polysaccharides on immunological function and expression of immune related cytokines in mice., Chin. J. Integr. Med. 14, 207–211 (2008). https://doi.org/10.1007/s11655-008-0207-2 DOI：

Yan-ling Zhao, Jia-bo Wang, Li-mei Shan, et al. Effect of Radix Isatidis polysaccharides on immunological function and expression of immune related cytokines in mice. [J]. Chinese Journal of Integrative Medicine 14(3):207-211(2008) DOI： 10.1007/s11655-008-0207-2.

摘要

To investigate the effect of Radix Isatidis polysaccharides (RIP) on the immunological function and expression of immune related cytokines in mice. Sixty mice were randomly divided into six groups

the normal group

cyclophosphamide (Cy) model group

Levamisole (positive control) group

RIP low

medium and high dose groups (0.08 g/kg

0.16 g/kg

0.32 g/kg

respectively)

ten in each group. By detecting the value of abdominal macrophage phagocytic index

serum hemolysin (HC50)

proliferation of lymphocytes and expression of related cytokines

interleukin (IL-2) and interferon γ (INF-γ)

the effect of RIP on immunological function and its mechanism were studied. RIP could improve the level of hemolysin in immunological function depressed mice. The results showed that the value of macrophage phagocytic index in the high dose RIP group increased from 1.11±0.13 to 1.42±0.26. The level of IL-2 and INF-γ could be decreased by Cy to 38.12±6.88 ng/L and 139.23±29.87 ng/L

respectively

while RIP in high dose could increase the secretion of IL-2 and INF-γ to 53.54±14.43 ng/L and 189.91±32.63 ng/L

respectively. RIP could enhance non-specific immunological function

humoral immunity and cellular immunity in mice.

Abstract

To investigate the effect of Radix Isatidis polysaccharides (RIP) on the immunological function and expression of immune related cytokines in mice. Sixty mice were randomly divided into six groups

the normal group

cyclophosphamide (Cy) model group

Levamisole (positive control) group

RIP low

medium and high dose groups (0.08 g/kg

0.16 g/kg

0.32 g/kg

respectively)

ten in each group. By detecting the value of abdominal macrophage phagocytic index

serum hemolysin (HC50)

proliferation of lymphocytes and expression of related cytokines

interleukin (IL-2) and interferon γ (INF-γ)

respectively

while RIP in high dose could increase the secretion of IL-2 and INF-γ to 53.54±14.43 ng/L and 189.91±32.63 ng/L

respectively. RIP could enhance non-specific immunological function

humoral immunity and cellular immunity in mice.

关键词

Radix Isatidis polysaccharidesmacrophageserum hemolysinlymphocytecytokine

Keywords

Radix Isatidis polysaccharidesmacrophageserum hemolysinlymphocytecytokine

references

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