Effect of Jinguo Weikang Capsule (金果胃康胶囊) on proto-oncogene expression of gastric mucosa in rats with gastric precancerous lesions

Shu-wen Shen; Ya Yuwen; Zhen-lu Zhang; Sheng Dong; Jun-tian Liu; Xiao-mei Wang

doi:10.1007/s11655-008-0212-3

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Effect of Jinguo Weikang Capsule (金果胃康胶囊) on proto-oncogene expression of gastric mucosa in rats with gastric precancerous lesions

Updated：2021-08-27

- Effect of Jinguo Weikang Capsule (金果胃康胶囊) on proto-oncogene expression of gastric mucosa in rats with gastric precancerous lesions
- Chinese Journal of Integrative Medicine Vol. 14, Issue 3, Pages: 212-216(2008)
- Affiliations：
  
  1. Shaanxi University of Chinese Medicine,Xianyang,China
  2. China Academy of Chinese Medical Sciences,Beijing,China
  3. Department of Pharmacology, Medical College, Xi’an Jiaotong University,Xi’an,China
- Author bio：
- Funds：
  
  Supported by the Bureau of Science and Techology of Shaanxi Province [No. 2002Kll-G7(6)]
- DOI：10.1007/s11655-008-0212-3
  CLC：
- Published：2008，
  
  Published Online：14 October 2008，
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Shen, Sw., Yuwen, Y., Zhang, Zl. et al. Effect of Jinguo Weikang Capsule (金果胃康胶囊) on proto-oncogene expression of gastric mucosa in rats with gastric precancerous lesions., Chin. J. Integr. Med. 14, 212–216 (2008). https://doi.org/10.1007/s11655-008-0212-3

Shu-wen Shen, Ya Yuwen, Zhen-lu Zhang, et al. Effect of Jinguo Weikang Capsule (金果胃康胶囊) on proto-oncogene expression of gastric mucosa in rats with gastric precancerous lesions. [J]. Chinese Journal of Integrative Medicine 14(3):212-216(2008)
Shen, Sw., Yuwen, Y., Zhang, Zl. et al. Effect of Jinguo Weikang Capsule (金果胃康胶囊) on proto-oncogene expression of gastric mucosa in rats with gastric precancerous lesions., Chin. J. Integr. Med. 14, 212–216 (2008). https://doi.org/10.1007/s11655-008-0212-3 DOI：

Shu-wen Shen, Ya Yuwen, Zhen-lu Zhang, et al. Effect of Jinguo Weikang Capsule (金果胃康胶囊) on proto-oncogene expression of gastric mucosa in rats with gastric precancerous lesions. [J]. Chinese Journal of Integrative Medicine 14(3):212-216(2008) DOI： 10.1007/s11655-008-0212-3.

摘要

To study the effect of Jinguo Weikang Capsule (金果胃康胶囊

JWC) on the gene expression of H-ras

epidermal growth factor receptor (EGFR)

P53 and C-myc of the gastric mucosa in rats with gastric precancerous lesions

and to investigate the action mechanism of JWC on gastric precancerous lesions. A rat model with paratypical proliferation of the gastric epithelium mucosa was established by using 60Co irradiation. Rats were divided into the normal group

model group

high-

medium-

low-dose JWC treatment groups

and the vitacoenzyme control group

and were treated for 30 days. The expression of H-ras

EGFR

P53 and C-myc genes of the gastric mucosa was detected by using immunohistochemical methods. The expression and over-expression rates of H-ras

EGFR

P53 and C-myc gene in the high-and medium-dose JWC treatment groups were significantly lower (P<0.05) as compared with those of the model group. JWC can inhibit the expression of the H-ras

EGFR

P53 and C-myc genes expression of the gastric mucosa in rats

which may be one of mechanisms involved in suppressing or reversing gastric carcinogenesis.

Abstract

To study the effect of Jinguo Weikang Capsule (金果胃康胶囊

JWC) on the gene expression of H-ras

epidermal growth factor receptor (EGFR)

P53 and C-myc of the gastric mucosa in rats with gastric precancerous lesions

model group

high-

medium-

low-dose JWC treatment groups

and the vitacoenzyme control group

and were treated for 30 days. The expression of H-ras

EGFR

P53 and C-myc genes of the gastric mucosa was detected by using immunohistochemical methods. The expression and over-expression rates of H-ras

EGFR

P53 and C-myc gene in the high-and medium-dose JWC treatment groups were significantly lower (P<0.05) as compared with those of the model group. JWC can inhibit the expression of the H-ras

EGFR

P53 and C-myc genes expression of the gastric mucosa in rats

which may be one of mechanisms involved in suppressing or reversing gastric carcinogenesis.

关键词

Jinguo Weikang Capsulegastric precancerous lesionproto-oncogene

Keywords

Jinguo Weikang Capsulegastric precancerous lesionproto-oncogene

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