Effect of Shengmai injection (生脉注射液) on vascular endothelial and heart functions in patients with coronary heart disease complicated with diabetes mellitus

Ya-chen Zhang; Bao-jing Lu; Mei-hua Zhao; Ye-zhi Rong; Rui-ming Chen

doi:10.1007/s11655-008-0281-3

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Effect of Shengmai injection (生脉注射液) on vascular endothelial and heart functions in patients with coronary heart disease complicated with diabetes mellitus

Updated：2021-08-27

- Effect of Shengmai injection (生脉注射液) on vascular endothelial and heart functions in patients with coronary heart disease complicated with diabetes mellitus
- Chinese Journal of Integrative Medicine Vol. 14, Issue 4, Pages: 281-285(2008)
- Affiliations：
  
  1. Department of Internal Cardiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University,Shanghai,China
  2. Department of Laboratory, Ruijin Hospital, Shanghai Jiaotong University School of Medicine,Shanghai,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-008-0281-3
  CLC：
- Published：2008，
  
  Published Online：12 December 2008，
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Zhang, Yc., Lu, Bj., Zhao, Mh. et al. Effect of Shengmai injection (生脉注射液) on vascular endothelial and heart functions in patients with coronary heart disease complicated with diabetes mellitus., Chin. J. Integr. Med. 14, 281 (2008). https://doi.org/10.1007/s11655-008-0281-3

Ya-chen Zhang, Bao-jing Lu, Mei-hua Zhao, et al. Effect of Shengmai injection (生脉注射液) on vascular endothelial and heart functions in patients with coronary heart disease complicated with diabetes mellitus. [J]. Chinese Journal of Integrative Medicine 14(4):281-285(2008)
Zhang, Yc., Lu, Bj., Zhao, Mh. et al. Effect of Shengmai injection (生脉注射液) on vascular endothelial and heart functions in patients with coronary heart disease complicated with diabetes mellitus., Chin. J. Integr. Med. 14, 281 (2008). https://doi.org/10.1007/s11655-008-0281-3 DOI：

Ya-chen Zhang, Bao-jing Lu, Mei-hua Zhao, et al. Effect of Shengmai injection (生脉注射液) on vascular endothelial and heart functions in patients with coronary heart disease complicated with diabetes mellitus. [J]. Chinese Journal of Integrative Medicine 14(4):281-285(2008) DOI： 10.1007/s11655-008-0281-3.

摘要

To study the effect of Shengmai injection (生脉注射液

SMI) on vascular endothelial and heart functions in coronary heart disease patients complicated with diabetes mellitus (CHD-DM). One hundred and twenty patients with CHD-DM

their diagnosis confirmed by coronary arteriography

were equally randomized into a control group treated with conventional treatment and a treated group treated with conventional treatment plus SMI. The changes in blood levels of nitric oxide (NO)

endothelin-1 (ET-1) and angiotensin II (Ang II)

as well as endothelium-dependent vascular dilating function and heart function in the patients were observed before treatment and after the 3-week treatment. After being treated with SMI for 3 weeks

in the treated group

blood level of NO was raised significantly from 69.8 ± 33.1 μ mol/L to 120.1 ± 50.8 μ mol/L

and ET-1 was lowered from 70.1 ± 32.1 ng/L to 46.2 ± 21.3 ng/L

respectively (P<0.01); that of Ang II was lowered from 81.3 ± 24.3 ng/L to 50.2 ± 27.3 ng/L (P<0.01); brachial arterial post-congestion blood flow increasing rate was raised from 389.4 ± 26.3% to 459.3 ± 27.8% (P<0.01); and the improvement in heart function as seen through the ejection fraction (EF) was increased from 44 ± 5% to 68 ± 6% (P<0.01)

all the changes being more significant than those in the control group (all P<0.01). SMI can improve not only the endothelial function in CHD-DM patients

but also heart contraction significantly.

Abstract

To study the effect of Shengmai injection (生脉注射液

SMI) on vascular endothelial and heart functions in coronary heart disease patients complicated with diabetes mellitus (CHD-DM). One hundred and twenty patients with CHD-DM

their diagnosis confirmed by coronary arteriography

were equally randomized into a control group treated with conventional treatment and a treated group treated with conventional treatment plus SMI. The changes in blood levels of nitric oxide (NO)

endothelin-1 (ET-1) and angiotensin II (Ang II)

as well as endothelium-dependent vascular dilating function and heart function in the patients were observed before treatment and after the 3-week treatment. After being treated with SMI for 3 weeks

in the treated group

blood level of NO was raised significantly from 69.8 ± 33.1 μ mol/L to 120.1 ± 50.8 μ mol/L

and ET-1 was lowered from 70.1 ± 32.1 ng/L to 46.2 ± 21.3 ng/L

all the changes being more significant than those in the control group (all P<0.01). SMI can improve not only the endothelial function in CHD-DM patients

but also heart contraction significantly.

关键词

Shengmai Injectioncoronary heart diseasediabetes mellitusvascular endothelial functionheart function

Keywords

Shengmai Injectioncoronary heart diseasediabetes mellitusvascular endothelial functionheart function

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Zhang YC, Cheng RM, Lu BJ, et al. Effect of Shengmai Injection (生脉注射液) on cardiac function and inflammatory reaction in patients with acute coronary syndrome. Chin J Integr Med 2008;14(2):107–110.

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