How to connect the gap between clinical trials and clinical practice

Hong-cai Shang; Hong-juan Xu; Jing Chen; Bo-li Zhang; You-ping Li; Mike J. Clarke

doi:10.1007/s11655-008-0309-8

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How to connect the gap between clinical trials and clinical practice

Updated：2021-08-27

- How to connect the gap between clinical trials and clinical practice
- Chinese Journal of Integrative Medicine Vol. 14, Issue 4, Pages: 309-311(2008)
- Affiliations：
  
  1. West China Hospital of Sichuan University,Chengdu,China
  2. Academy of TCM in Tianjin University of Traditional Chinese Medicine,Tianjin,China
  3. Evidence-Based Medicine Centre in Tianjin University of TCM,Tianjin,China
  4. Heart Department in Tianjin Chest Hospital,Tianjin,China
  5. UK Cochrane Centre,Oxford,UK
- Author bio：
- Funds：
  
  Supported by the National Key Technologies R&D Program (2004BA716B01), National Natural Science Foundation of China (30600834), and China Postdoctoral Science Foundation (20070411156)
- DOI：10.1007/s11655-008-0309-8
  CLC：
- Published：2008，
  
  Published Online：12 December 2008，
Scan for full text
Shang, Hc., Xu, Hj., Chen, J. et al. How to connect the gap between clinical trials and clinical practice., Chin. J. Integr. Med. 14, 309–311 (2008). https://doi.org/10.1007/s11655-008-0309-8

Hong-cai Shang, Hong-juan Xu, Jing Chen, et al. How to connect the gap between clinical trials and clinical practice. [J]. Chinese Journal of Integrative Medicine 14(4):309-311(2008)
Shang, Hc., Xu, Hj., Chen, J. et al. How to connect the gap between clinical trials and clinical practice., Chin. J. Integr. Med. 14, 309–311 (2008). https://doi.org/10.1007/s11655-008-0309-8 DOI：

Hong-cai Shang, Hong-juan Xu, Jing Chen, et al. How to connect the gap between clinical trials and clinical practice. [J]. Chinese Journal of Integrative Medicine 14(4):309-311(2008) DOI： 10.1007/s11655-008-0309-8.

摘要

Clinical research methods have been rapidly developing

and the design of clinical trials including traditional Chinese medicine is advancing. To a certain extent

all of these ensure that the results of clinical research are objective and scientific

but whether these results and the resulting guidelines or consensus have much practical significance on clinical practice is still controversial. The authors engage in both clinical practice and clinical research; they strongly feel that it is necessary to discuss the relationship between clinical trials and clinical practice. This essay discusses this relationship in four parts.

Abstract

Clinical research methods have been rapidly developing

and the design of clinical trials including traditional Chinese medicine is advancing. To a certain extent

all of these ensure that the results of clinical research are objective and scientific

关键词

clinical trialsClinical Practiceexternal validity

Keywords

clinical trialsClinical Practiceexternal validity

references

Stegmair B, Asplund K, Hulter-Asberg K, et al. Stroke units in their natural habitat: can results of randomized trials be reproduced in routine clinical practice? Riks-Stroke Collaboration. Stroke 1999;30:709–714.

French JA. Can evidence-based guidelines and clinical trials tell us how to treat patients? Epilepsia 2007;48:1264–1267.

Steg PG, Lopez-Sendon J, Lopez de Sa E, et al. External validity of clinical trials in acute myocardial infarction. Arch Intern Med 2007; 167:68–73.

Richard S. Doctors are not scientists. BMJ 2004; 328:0. (doi:10.1136/bmj.328.7454.0-h)

Krasopoulos G, Brister SJ, Beattie WS, et al. Aspirin “resistance” and risk of cardiovascular morbidity: systematic review and meta-analysis. BMJ 2008;336:195–198.

Walach H, Falkenberg T, Fonnebo V, et al. Circular instead of hierarchical: methodological principles for the evaluation of complex interventions. BMC Med Res Methodol 2006;6:29.

Straus S, Richardson WS, Glasziou P, et al, ed. Zhan SY, translate. Evidence-based medicine: bow to practice and teach EBM. Beijing: Beijing University Medical Press, 2006:142.

Rothwell PM. External validity of randomized controlled trials:“to whom do the results of this trial apply?” Lancet 2005; 365:82–93.

Trial participants need to be more representive of patients. BMJ2008; 336:737.

Frye RL, Brooks MM, Nesto RW. Gap between clinical trials and clinical practice: Lessons from the Bypass Angioplasty Revascularization Investigation (BARI). Circulation 2003;107;1837–1839.

Gray JA Muir, ed. Qin Y, Tang JL, translate. The resourceful patient. Beijing: Peking University Medical Press, 2006: 44.

Eldridge S, Ashby D, Bennett C, et al. Internal and external validity of cluster randomized trials: systematic review of recent trials. BMJ 2008;336:876–880.

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